S W J McPhee

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease
    S W J McPhee
    Cell and Gene Therapy Center, UMDNJ Robert Wood Johnson Medical School, 401 Haddon Avenue, Suite 395, Camden, NJ 08103, USA
    Brain Res Mol Brain Res 135:112-21. 2005
  2. ncbi Immune responses to AAV in a phase I study for Canavan disease
    S W J McPhee
    Department of Surgery, Division of Neurosurgery, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 401 Haddon Avenue, Camden, NJ 08103, USA
    J Gene Med 8:577-88. 2006
  3. ncbi Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI
    C G Janson
    UMDNJ Robert Wood Johnson Medical School, Dept of Neurosurgery, Camden, NJ 08103, USA
    Neuropediatrics 37:209-21. 2006

Collaborators

Detail Information

Publications3

  1. ncbi Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease
    S W J McPhee
    Cell and Gene Therapy Center, UMDNJ Robert Wood Johnson Medical School, 401 Haddon Avenue, Suite 395, Camden, NJ 08103, USA
    Brain Res Mol Brain Res 135:112-21. 2005
    ..This study provides evidence that AAV-2-mediated aspartoacylase gene transfer to the brain improves biochemical and behavioral deficits in tremor rat mutants (tm/tm) and supports the rationale of human gene transfer for Canavan disease...
  2. ncbi Immune responses to AAV in a phase I study for Canavan disease
    S W J McPhee
    Department of Surgery, Division of Neurosurgery, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 401 Haddon Avenue, Camden, NJ 08103, USA
    J Gene Med 8:577-88. 2006
    ..Long-term monitoring of subjects and expansion to phase II/III will be necessary in order to make definitive statements on safety and efficacy...
  3. ncbi Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI
    C G Janson
    UMDNJ Robert Wood Johnson Medical School, Dept of Neurosurgery, Camden, NJ 08103, USA
    Neuropediatrics 37:209-21. 2006
    ..The resultant model can be used to non-invasively monitor the natural history of Canavan disease or related leukodystrophies in future studies involving drug, gene therapy, or stem cell treatments...