Research Topics
Genomes and Genes
| Chuan Ju LiuSummaryAffiliation: New York University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteinsChuan Ju Liu
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
Mol Cell Biol 22:2893-905. 2002....- Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivatorsChuan Ju Liu
Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10003, USA
Front Biosci 12:3899-910. 2007..This study provides the first evidence that Sox9 directly associates with COMP gene promoter and that mediation of COMP gene activation by Sox9 involves Sox5, Sox6, CBP, and p300 coactivators... - ADAMTS-12 associates with and degrades cartilage oligomeric matrix proteinChuan Ju Liu
Department of Orthopaedic Surgery, Musculoskeletal Research Center, New York University Hospital for Joint Diseases, New York, New York 10003, USA
J Biol Chem 281:15800-8. 2006..Together, these findings indicate that ADAMTS-12 is a new COMP-interacting and -degrading enzyme and thus may play an important role in the COMP degradation in the initiation and progression of arthritis... - ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix proteinChuan Ju Liu
Musculoskeletal Research Center, New York University Hospital for Joint Diseases Department of Orthopaedic Surgery, School of Medicine, 301 East 17th St, New York, New York 10003, USA
FASEB J 20:988-90. 2006..ADAMTS-7 is the first metalloproteinase found to bind directly to and degrade COMP... - The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritisChuan Ju Liu
New York University School of Medicine, New York, NY 10003, USA
Nat Clin Pract Rheumatol 5:38-45. 2009.... - Transcriptional mechanism of COMP gene expression and chondrogenesisC Liu
Musculoskeletal Research Center, Department of Orthopedic Surgery, New York University School of Medicine, New York, NY, USA
J Musculoskelet Neuronal Interact 5:340-1. 2005 - MicroRNAs in skeletogenesisChuan Ju Liu
Department of Orthopaedic Surgery, New York University School of Medicine, New York, New York 10003, USA
Front Biosci 14:2757-64. 2009.... - The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiationChuan Ju Liu
Musculoskeletal Research Center and Department of Orthopaedic Surgery, New York University, Hospital for Joint Diseases, New York, New York 10003, USA
J Biol Chem 280:2788-96. 2005..p204, which is the first interferon-inducible protein found to associate with Cbfa1, functions as a novel regulator of osteoblast differentiation... - Progranulin: a promising therapeutic target for rheumatoid arthritisChuan Ju Liu
Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
FEBS Lett 585:3675-80. 2011.... - Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesisChuan Ju Liu
Musculoskeletal Research Center, New York University Hospital for Joint Diseases Department of Orthopedic Surgery, New York, New York 10003, USA
J Biol Chem 279:47081-91. 2004..LRF is the first transcription factor found to bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation... - The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activityYi Luan
Department of Orthopedic Surgery, New York University Medical Center, New York, New York 10003, USA
J Biol Chem 282:16860-70. 2007..Furthermore, as revealed in reporter gene and in vitro osteogenesis assays p204 synergized with pRb in the stimulation of Cbfa1-dependent gene activation and osteoblast differentiation... - p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteinsYi Luan
Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, USA
Mol Biol Cell 19:2113-26. 2008..Together, Cbfa1, p204, and Id proteins form a regulatory circuit and act in concert to regulate osteoblast differentiation... - ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factorXiao Hui Bai
Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 100031, USA
Mol Cell Biol 29:4201-19. 2009..Collectively, these findings demonstrate that ADAMTS-7, a direct target of PTHrP signaling, negatively regulates endochondral bone formation by associating with and inactivating GEP chondrogenic growth factor... - Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferationKe Xu
Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, New York 10003, USA
J Biol Chem 282:11347-55. 2007..These findings provide the first evidence linking the association of COMP and GEP and identifying a previously unrecognized growth factor (i.e. GEP) in cartilage... - A silencer element in the cartilage oligomeric matrix protein gene regulates chondrocyte-specific expressionPaul S Issack
Department of Orthopaedic Surgery, Musculoskeletal Research Center, Hospital for Joint Diseases, NYU, 301 East 17th Street, New York, NY, USA
J Orthop Res 22:751-8. 2004..These results suggest that negative regulation of transcription is an important mechanism for chondrocyte-specific expression of the COMP gene... - IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cellsYan Zhang
Department of Orthopaedic Surgery, New York University School of Medicine, New York, New York 10003, USA
Front Biosci 12:4855-63. 2007..In view of such effects, IFI16 might be a suitable target for therapeutic intervention in osteosarcoma and chondrosarcoma... - Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growthLi Kong
Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, United States
Matrix Biol 29:276-86. 2010..These findings provide the first evidence linking the association of COMP and ECM1 and the biological significance underlying the interaction between them in regulating endochondral bone growth... - p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiationYi Luan
Department of Orthopaedic Surgery, New York University School of Medicine, New York, 10003, United States
Cytokine Growth Factor Rev 19:357-69. 2008..The expression of p204 in various tissues as promoted by tissue-specific transcription factors, its distribution among subcellular compartments, and the controls of these features are also discussed... - Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na+-dependent bile acid transporter: protein-protein interaction and intracellular traffickingAn Qiang Sun
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 279:16295-300. 2004..Thus, these results suggest that the apical membrane localization of Asbt is mediated in part by the vacuolar proton pump associated apical sorting machinery... - RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancerLi Kong
Department of Orthopaedic Surgery, New York University Medical Center, New York, New York 10003, USA
J Biol Chem 282:26381-91. 2007..In brief, RbAp48, previously unknown in cervical carcinogenesis, was isolated in a global screen and identified as a critical mediator controlling the transforming activity of HPV16 in cervical cancer... - Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot studyMarc Fajardo
Musculoskeletal Research Institute and The Bone Healing Center, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
Clin Orthop Relat Res 467:3071-8. 2009..In contrast, BMP-7 concentration was higher in the healing bone. Our data suggest inhibition of BMP-7, by Drm (Gremlin), follistatin, and Noggin and upregulation of BMP-4 may play an integral role in the development of nonunions... - miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1Edward A Lin
Department of Orthopaedic Surgery, New York University School of Medicine, New York, New York 10003, USA
J Biol Chem 284:11326-35. 2009..Taken together, miR-199a(*) is the first BMP2 responsive microRNA found to adversely regulate early chondrocyte differentiation via direct targeting of the Smad1 transcription factor... - Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissueMarc Fajardo
Musculoskeletal Research Institute and The Bone Healing Center, New York University Hospital for Joint Diseases, New York, NY 10003, USA
J Orthop Trauma 24:557-63. 2010.... - The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in miceWei Tang
Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
Science 332:478-84. 2011..They also suggest new potential therapeutic interventions for various TNF?-mediated pathologies and conditions, including rheumatoid arthritis... - Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplastyPaul E Di Cesare
Musculoskeletal Research Center, Room 1500, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
J Bone Joint Surg Am 87:1921-7. 2005.... - The role of ADAMTSs in arthritisEdward A Lin
Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, USA
Protein Cell 1:33-47. 2010..g., TIMP-3, alpha-2-macroglobulin, GEP), and activation (e.g., syndecan-4, PACE-4)... - Protein-protein interactions and membrane localization of the human organic solute transporterAn Qiang Sun
Dept of Pediatrics, Box 1664, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
Am J Physiol Gastrointest Liver Physiol 292:G1586-93. 2007..The extracellular amino-terminal fragment of hOST-alpha may contain important information for the assembly of the heterodimer and trafficking to the plasma membrane... - Progranulin: a growth factor, a novel TNFR ligand and a drug targetChuan Ju Liu
Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, United States
Pharmacol Ther 133:124-32. 2012..As we discuss here, TNFR-based interventions may both stimulate and suppress the growth of cancer cells, and the same may be true in analogy for Atsttrin as a new player... - Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiaeC Liu
Cornell University, Graduate School of Medical Sciences, New York, New York 10021, USA
Genetics 143:81-93. 1996..We propose that this telomere-specific synergism is mediated in part through stabilization of Rap1p/Sir3p telometric complexes by Sir3p-Sir3p interactions... - p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteinsBo Ding
Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, CT 06520 8024, USA
J Biol Chem 281:14893-906. 2006..5, and p204 were components of a positive feedback loop. This loop arose in consequence of it that p204 overcame the inhibition of the synergistic activity of Gata4 and Nkx2.5 by the Id proteins... - p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteinsBo Ding
Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, CT 06520 8024, USA
J Biol Chem 281:14882-92. 2006..The various mechanisms by which p204 promoted the differentiation are reported in the accompanying article (Ding, B., Liu, C., Huang, Y., Yu, J., Kong, W., and Lengyel, P. (2006) J. Biol. Chem. 281, 14893-14906)...
Research Grants
- THE ROLE OF p204 IN OSTEOGENESISChuanju Liu; Fiscal Year: 2007..A greater understanding of the process of how bone is generated can lead to new therapies which can help stem or reverse the course of these diseases. ..
- Role and Regulation of ADAMTS-12 in the Cartilage CatabolismChuanju Liu; Fiscal Year: 2007....
- Degradative COMP Fragments as a Biomarker of ArthritisChuanju Liu; Fiscal Year: 2007....
- Physiological Role of ADAMTS-7B in ArthritisChuanju Liu; Fiscal Year: 2007..The proposed study will extend our understanding of the degradative events that occur in patients with arthritic disorders and may provide us with inhibitors designed to serve as therapeutics for the treatment of arthritis. ..