Research Topics
Species | J J LafailleSummaryAffiliation: New York University Country: USA Publications
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Publications
The role of helper T cell subsets in autoimmune diseasesJ J Lafaille
Skirball Institute for Biomedical Research and Dept of Pathology, New York University School of Medicine, NY, USA
Cytokine Growth Factor Rev 9:139-51. 1998..In addition, we examine some recent data suggesting that, under some circumstances, Th2 cells can be pathogenic...- T-cell receptor transgenic mice in the study of autoimmune diseasesJuan J Lafaille
Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
J Autoimmun 22:95-106. 2004.... - Oral tolerance in the absence of naturally occurring TregsDaniel Mucida
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Clin Invest 115:1923-33. 2005..However, unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunization led to the simultaneous induction of Tregs and effector Th2 cells displaying the same antigen specificity... - Regulatory T cells in spontaneous autoimmune encephalomyelitisG C Furtado
Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Immunol Rev 182:122-34. 2001.... - The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunityA Wensky
Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University Medical Center, New York, NY 10016, USA
J Immunol 167:3074-81. 2001.... - The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsIvaylo I Ivanov
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 126:1121-33. 2006..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases... - Control of homeostatic proliferation by regulatory T cellsShiqian Shen
Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Clin Invest 115:3517-26. 2005..The presence of Tregs resulted in a lower accumulation of T cells, enhanced apoptosis, and impaired differentiation to a cytokine-producing state. We conclude that Tregs play a major role in the control of homeostatic proliferation... - Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitisMitsuyuki Murano
Department of Pathology, NYU Cancer Institute, School of Medicine, New York, NY, USA
J Leukoc Biol 79:140-6. 2006..PL mice. Furthermore, the GFP+ TGF-beta1-producing Th2 cells were detectable in the spinal cords of the injected mice... - Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitisGlaucia C Furtado
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
J Immunol 181:4648-55. 2008..Taken together, our results suggest that peripheral activation of T cells in draining lymph nodes is an early event in the development of EAE, which paves the way for the initial burst of IFN-gamma-producing CD4(+) T cell into the CNS... - IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitisAllen K Wensky
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
J Immunol 174:1416-23. 2005.... - TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizesMonica W L Leung
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 206:2121-30. 2009..Our results indicate that although the TCR has an instructive role in determining Foxp3 expression, selection of Foxp3(+) individual clones in the thymus is limited by a very small niche... - The role of regulatory T cells in allergyMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, NY 10016, USA
Springer Semin Immunopathol 25:295-310. 2004..This article reviews the recent progress on thymic-derived as well as peripherally induced regulatory T cells as they relate to atopy. The latter discussion also includes regulatory T cells that arise through immunotherapy... - Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivoCarlos E Tadokoro
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 203:505-11. 2006..Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs... - CD4(+) regulatory T cells in autoimmunity and allergyMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and Department of Pathology New York University School of Medicine, New York, NY 10016, USA
Curr Opin Immunol 14:771-8. 2002.... - Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sitesJiyun V Kim
Helen L and Martin S Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
J Immunol Methods 352:89-100. 2010..Interestingly, infiltration of the cerebral cortex by GFP(+) cells in these mice required three conditions: EAE induction, cortical injury and expression of CXCR6 on immune cells... - Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?Maria A Curotto de Lafaille
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Immunity 30:626-35. 2009.... - CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansionMaria A Curotto de Lafaille
Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Immunol 173:7259-68. 2004..The maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs... - Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammationMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Immunity 29:114-26. 2008..Thus, whereas adaptive Foxp3(+) Treg cells regulate sensitization to allergens and the severity of chronic inflammation, IFN-gamma-producing cells can play a beneficial role in inflammatory conditions involving eosinophils... - Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stagesG Sano
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
J Exp Med 194:173-80. 2001..These results indicate that differentiation of naive CD8(+) T cells does not begin only after extensive cell division, rather this process precedes or occurs simultaneously with proliferation... - Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitisMaria Cecilia G Marcondes
Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, USA
Am J Pathol 166:1749-60. 2005..Overall, our results suggest that common mechanisms regulate T-cell accumulation in CNS lesions of different causes, such as mechanic lesion or autoimmune-mediated damage... - Unique maturation program of the IgE response in vivoAgustin Erazo
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Immunity 26:191-203. 2007..Our results have implications for the understanding of IgE memory responses in allergy... - Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cellsYi Ding
Molecular Pathogenesis Program and Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nat Med 14:162-9. 2008..Thus, through enhanced survival of existing regulatory T cells, and through induction of unresponsiveness in precursors of T effector cells, beta-catenin stabilization has a powerful effect on the prevention of inflammatory disease... - Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cellsAntonio Maraver
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 1st Avenue, New York, NY 10016, USA
Blood 110:3218-25. 2007.... - Protein kinase C-theta mediates negative feedback on regulatory T cell functionAlexandra Zanin-Zhorov
Molecular Pathogenesis Program, Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Science 328:372-6. 2010..Treg freed of PKC-theta-mediated inhibition can function in the presence of inflammatory cytokines and thus have therapeutic potential in control of inflammatory diseases... - Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malariaJulius C R Hafalla
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA
J Immunol 171:964-70. 2003.... - Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytesM A Curotto de Lafaille
Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 194:1349-59. 2001..Our results indicate that hyper IgE responses do not occur in normal individuals due to the presence of regulatory T cells, and imply that the induction of regulatory CD4(+) T cells could be used for the prevention of atopy... - Do regulatory T cells play a role in the control of homeostatic proliferation?Maria A Curotto de Lafaille
Molecular Pathogenesis Progam, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York 10016, USA
Int Rev Immunol 24:269-84. 2005..One of these relates to the stage at which regulatory T cells could play a role (i.e., T-cell proliferation vs. survival)... - Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic miceShohei Hori
, Oeiras, Portugal
Eur J Immunol 32:3729-35. 2002..These observations thus exclude peripheral differentiation of Treg in this particular system, and indicate that expansion of thymically committed cells ensures the maintenance of the peripheral Treg pool in the adult...
Research Grants
- LYMPHOCYTES THAT SUPPRESS EAEJuan LaFaille; Fiscal Year: 2001..The increased understanding of negative regulation and control provided by this defined system is potentially applicable not only to MS, but also to other autoimmune diseases and to the knowledge of tolerance in general. ..
- IN VIVO REGULATION OF IGE PRODUCTIONJuan LaFaille; Fiscal Year: 2005..We believe that the proposed experiments will enhance our knowledge on the regulation of IgE production in response to antigen, and will open new avenues for therapy of atopic disease. ..
- Charaterizing lymphocytes that suppress Experimental Autoimmune EncephalomyelitisJuan LaFaille; Fiscal Year: 2007..The characteristics of MHC restriction of T-reg cells may help in the design of strategies to purify these cells out of the total CD4+ T cell compartment. ..