K Drlica

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi DNA gyrase, topoisomerase IV, and the 4-quinolones
    K Drlica
    Public Health Research Institute, New York, New York 10016, USA
    Microbiol Mol Biol Rev 61:377-92. 1997
  2. ncbi Mechanism of fluoroquinolone action
    K Drlica
    Public Health Research Institute 455 First Avenue, New York, NY 10016, USA
    Curr Opin Microbiol 2:504-8. 1999
  3. ncbi DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage
    C R Chen
    Public Health Research Institute, New York, NY 10016, USA
    J Mol Biol 258:627-37. 1996
  4. ncbi Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region
    S M Friedman
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    Antimicrob Agents Chemother 45:2378-80. 2001
  5. ncbi Enhancement of fluoroquinolone activity by C-8 halogen and methoxy moieties: action against a gyrase resistance mutant of Mycobacterium smegmatis and a gyrase-topoisomerase IV double mutant of Staphylococcus aureus
    T Lu
    Public Health Research Institute, 455 First Ave, New York, NY 10016, USA
    Antimicrob Agents Chemother 45:2703-9. 2001
  6. ncbi Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies
    X Zhao
    Public Health Research Institute, New York, NY 10016, USA
    Clin Infect Dis 33:S147-56. 2001
  7. ncbi Control of bacterial DNA supercoiling
    K Drlica
    Public Health Research Institute, New York, New York 10016
    Mol Microbiol 6:425-33. 1992
  8. ncbi RNases involved in ribozyme degradation in Escherichia coli
    J Y Wang
    Public Health Research Institute, New York 10016, USA
    J Bacteriol 178:1640-5. 1996
  9. ncbi Therapeutic options in an era of decreasing antimicrobial susceptibility
    K Drlica
    Public Health Research Institute, New York, NY 10016, United States
    J Chemother 14:5-12. 2002

Collaborators

Detail Information

Publications9

  1. ncbi DNA gyrase, topoisomerase IV, and the 4-quinolones
    K Drlica
    Public Health Research Institute, New York, New York 10016, USA
    Microbiol Mol Biol Rev 61:377-92. 1997
    ..Thus, quinolone-topoisomerase biology is providing a model for understanding aspects of host-parasite interactions and providing ways to investigate manipulation of the bacterial chromosome by topoisomerases...
  2. ncbi Mechanism of fluoroquinolone action
    K Drlica
    Public Health Research Institute 455 First Avenue, New York, NY 10016, USA
    Curr Opin Microbiol 2:504-8. 1999
    ..Preferential localization of gyrase ahead of replication forks and topoisomerase IV behind them causes fluoroquinolone-mediated complexes with the two enzymes to have different physiological consequences...
  3. ncbi DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage
    C R Chen
    Public Health Research Institute, New York, NY 10016, USA
    J Mol Biol 258:627-37. 1996
    ..coli. These findings provide a molecular explanation for quinolone action in bacteria and a new way to study topoisomerase IV-chromosome interactions...
  4. ncbi Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region
    S M Friedman
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    Antimicrob Agents Chemother 45:2378-80. 2001
    ..Revision of the QRDR to include amino acid 51 is indicated...
  5. ncbi Enhancement of fluoroquinolone activity by C-8 halogen and methoxy moieties: action against a gyrase resistance mutant of Mycobacterium smegmatis and a gyrase-topoisomerase IV double mutant of Staphylococcus aureus
    T Lu
    Public Health Research Institute, 455 First Ave, New York, NY 10016, USA
    Antimicrob Agents Chemother 45:2703-9. 2001
    ....
  6. ncbi Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies
    X Zhao
    Public Health Research Institute, New York, NY 10016, USA
    Clin Infect Dis 33:S147-56. 2001
    ..Application of these principles could drastically restrict the selection of drug-resistant pathogens...
  7. ncbi Control of bacterial DNA supercoiling
    K Drlica
    Public Health Research Institute, New York, New York 10016
    Mol Microbiol 6:425-33. 1992
    ..However, a steady-state change in supercoiling caused by mutation of topA does alter both tension and restrained supercoils. This communication between the two compartments may play a role in the control of supercoiling...
  8. ncbi RNases involved in ribozyme degradation in Escherichia coli
    J Y Wang
    Public Health Research Institute, New York 10016, USA
    J Bacteriol 178:1640-5. 1996
    ..Taken together, these data indicate that hammerhead ribozymes are digested largely by the degradative class of RNase (RNases I, I* and II and polynucleotide phosphorylase)...
  9. ncbi Therapeutic options in an era of decreasing antimicrobial susceptibility
    K Drlica
    Public Health Research Institute, New York, NY 10016, United States
    J Chemother 14:5-12. 2002
    ..Clinical trials are now needed to determine how well preclinical profiles of these drugs correlate with the prevention of resistance...