Research Topics
Genomes and Genes | Maria A Curotto de LafailleSummaryAffiliation: New York University Country: USA Publications
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Publications
CD4(+) regulatory T cells in autoimmunity and allergyMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and Department of Pathology New York University School of Medicine, New York, NY 10016, USA
Curr Opin Immunol 14:771-8. 2002....- Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammationMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Immunity 29:114-26. 2008..Thus, whereas adaptive Foxp3(+) Treg cells regulate sensitization to allergens and the severity of chronic inflammation, IFN-gamma-producing cells can play a beneficial role in inflammatory conditions involving eosinophils... - The role of regulatory T cells in allergyMaria A Curotto de Lafaille
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, NY 10016, USA
Springer Semin Immunopathol 25:295-310. 2004..This article reviews the recent progress on thymic-derived as well as peripherally induced regulatory T cells as they relate to atopy. The latter discussion also includes regulatory T cells that arise through immunotherapy... - CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansionMaria A Curotto de Lafaille
Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Immunol 173:7259-68. 2004..The maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs... - Control of homeostatic proliferation by regulatory T cellsShiqian Shen
Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Clin Invest 115:3517-26. 2005..The presence of Tregs resulted in a lower accumulation of T cells, enhanced apoptosis, and impaired differentiation to a cytokine-producing state. We conclude that Tregs play a major role in the control of homeostatic proliferation... - Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietinBertram Bleck
Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, 550 1st Avenue, Room NB7N24, New York, NY, USA
J Clin Immunol 28:147-56. 2008..These findings provide new insight into the mechanisms by which diesel exhaust particles modify human lung mucosal immunity... - Oral tolerance in the absence of naturally occurring TregsDaniel Mucida
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Clin Invest 115:1923-33. 2005..However, unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunization led to the simultaneous induction of Tregs and effector Th2 cells displaying the same antigen specificity... - Unique maturation program of the IgE response in vivoAgustin Erazo
Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Immunity 26:191-203. 2007..Our results have implications for the understanding of IgE memory responses in allergy... - Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?Maria A Curotto de Lafaille
Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Immunity 30:626-35. 2009.... - Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cellsYi Ding
Molecular Pathogenesis Program and Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nat Med 14:162-9. 2008..Thus, through enhanced survival of existing regulatory T cells, and through induction of unresponsiveness in precursors of T effector cells, beta-catenin stabilization has a powerful effect on the prevention of inflammatory disease... - Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitisMaria Cecilia G Marcondes
Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, USA
Am J Pathol 166:1749-60. 2005..Overall, our results suggest that common mechanisms regulate T-cell accumulation in CNS lesions of different causes, such as mechanic lesion or autoimmune-mediated damage... - Sequential class switching is required for the generation of high affinity IgE antibodiesHuizhong Xiong
The Skirball Institute of Biomolecular Medicine, The Sackler Institute of Graduate Biomedical Sciences, 3 Department of Pathology and 4 Department of Medicine New York University School of Medicine, New York, NY 10016
J Exp Med 209:353-64. 2012..We demonstrate that a small amount of high affinity IgE can cause anaphylaxis and is pathogenic. Low affinity IgE competes with high affinity IgE for binding to Fc? receptors and prevents anaphylaxis and is thus beneficial... - Do regulatory T cells play a role in the control of homeostatic proliferation?Maria A Curotto de Lafaille
Molecular Pathogenesis Progam, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York 10016, USA
Int Rev Immunol 24:269-84. 2005..One of these relates to the stage at which regulatory T cells could play a role (i.e., T-cell proliferation vs. survival)... - Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cellsMegan L McCloskey
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 208:135-48. 2011..These results significantly broaden the scope of FDC function and suggest new ways that the complement system and persistent antigen presentation might influence T cell activation and the maintenance of peripheral immune tolerance... - Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturationBertram Bleck
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, NY 10016, USA
J Immunol 176:7431-7. 2006..Although additional signals may be required for polarization of DC, these data suggest a novel mechanism by which environmental pollutants alter airway immune responses... - The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responsesEmanuel Fournier
Department of Pharmacology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
Curr Biol 13:1858-66. 2003..Bam32/DAPP1 is a B cell adaptor composed of both a PH and an SH2 domain. Previous studies in cell culture and chicken DT40 cells have indicated that Bam32 is critical for normal signaling downstream of the B cell receptor (BCR)... - IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stagesLuzia H Carvalho
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, USA
Nat Med 8:166-70. 2002..This is the first demonstration that IL-4 is a mediator of CD4/CD8 cross-talk leading to the development of immunity against an infectious pathogen...