Paul Copeland

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi Size matters: a view of selenocysteine incorporation from the ribosome
    K Caban
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cell Mol Life Sci 63:73-81. 2006
  2. ncbi Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins
    Jesse Donovan
    Department of Molecular Genetics, Microbiology, and Immunology, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ, USA
    BMC Evol Biol 9:229. 2009
  3. ncbi Regulation of gene expression by stop codon recoding: selenocysteine
    Paul R Copeland
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Ln Rm 728, Piscataway, NJ 08854, USA
    Gene 312:17-25. 2003
  4. ncbi Making sense of nonsense: the evolution of selenocysteine usage in proteins
    Paul R Copeland
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Genome Biol 6:221. 2005
  5. ncbi Characterization of the SECIS binding protein 2 complex required for the co-translational insertion of selenocysteine in mammals
    Scott A Kinzy
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Nucleic Acids Res 33:5172-80. 2005
  6. ncbi The L7Ae RNA binding motif is a multifunctional domain required for the ribosome-dependent Sec incorporation activity of Sec insertion sequence binding protein 2
    Kelvin Caban
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Mol Cell Biol 27:6350-60. 2007
  7. ncbi A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment
    Jesse Donovan
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 283:35129-39. 2008
  8. ncbi Functional analysis of the interplay between translation termination, selenocysteine codon context, and selenocysteine insertion sequence-binding protein 2
    Malavika Gupta
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:36797-807. 2007
  9. ncbi Threading the needle: getting selenocysteine into proteins
    Jesse Donovan
    Department of Microbiology, Molecular Genetics, and Immunology, Graduate School of Biomedical Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 12:881-92. 2010
  10. ncbi The efficiency of selenocysteine incorporation is regulated by translation initiation factors
    Jesse Donovan
    Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Mol Biol 400:659-64. 2010

Research Grants

  1. Expanding The Genetic Code In Yeast
    Paul R Copeland; Fiscal Year: 2010
  2. Functional analysis of SBP2 and selenocysteine incorporation
    Paul Copeland; Fiscal Year: 2009
  3. Functional analysis of SBP2 and selenocysteine incorporation
    Paul Copeland; Fiscal Year: 2007
  4. The translational control of selenoprotein synthesis
    Paul Copeland; Fiscal Year: 2007
  5. Functional analysis of SBP2 and selenocysteine incorporation
    Paul Copeland; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. ncbi Size matters: a view of selenocysteine incorporation from the ribosome
    K Caban
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cell Mol Life Sci 63:73-81. 2006
    ..The role of the ribosome in this process is emphasized along with a detailed analysis of kinkturn structures present in the ribosome and the L7Ae RNA-binding motif present in SBP2 and other proteins...
  2. ncbi Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins
    Jesse Donovan
    Department of Molecular Genetics, Microbiology, and Immunology, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ, USA
    BMC Evol Biol 9:229. 2009
    ..While the phylogenetic relationships of selenoprotein families and the evolution of selenocysteine usage are well documented, the evolutionary history of SECIS binding proteins has not been explored...
  3. ncbi Regulation of gene expression by stop codon recoding: selenocysteine
    Paul R Copeland
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Ln Rm 728, Piscataway, NJ 08854, USA
    Gene 312:17-25. 2003
    ....
  4. ncbi Making sense of nonsense: the evolution of selenocysteine usage in proteins
    Paul R Copeland
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Genome Biol 6:221. 2005
    ....
  5. ncbi Characterization of the SECIS binding protein 2 complex required for the co-translational insertion of selenocysteine in mammals
    Scott A Kinzy
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Nucleic Acids Res 33:5172-80. 2005
    ..Based on these results, we propose a revised model for selenocysteine incorporation where SBP2 remains ribosome bound except during selenocysteine delivery to the ribosomal A-site...
  6. ncbi The L7Ae RNA binding motif is a multifunctional domain required for the ribosome-dependent Sec incorporation activity of Sec insertion sequence binding protein 2
    Kelvin Caban
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Mol Cell Biol 27:6350-60. 2007
    ..5-kDa protein-U4 snRNA complex strongly supports a two-site model for L7Ae domain function within SBP2. These results provide evidence that the SBP2-ribosome interaction is essential for Sec incorporation...
  7. ncbi A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment
    Jesse Donovan
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 283:35129-39. 2008
    ..We propose a model in which SECIS binding induces a conformational change in SBP2 that recruits eEFSec, which in concert with the Sec incorporation domain gains access to the ribosomal A site...
  8. ncbi Functional analysis of the interplay between translation termination, selenocysteine codon context, and selenocysteine insertion sequence-binding protein 2
    Malavika Gupta
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:36797-807. 2007
    ..We conclude that a large codon context forms a cis-element that works together with Sec incorporation factors to determine readthrough efficiency...
  9. ncbi Threading the needle: getting selenocysteine into proteins
    Jesse Donovan
    Department of Microbiology, Molecular Genetics, and Immunology, Graduate School of Biomedical Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 12:881-92. 2010
    ..The mechanism by which they alter the canonical protein synthesis reaction has been elusive. Here we present an overview of the mechanistic perspective on Sec incorporation, highlighting recent advances in the field...
  10. ncbi The efficiency of selenocysteine incorporation is regulated by translation initiation factors
    Jesse Donovan
    Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Mol Biol 400:659-64. 2010
    ..Interestingly, however, the presence of the internal ribosome entry site significantly decreases Sec incorporation efficiency, suggesting a role for translation initiation in regulating the efficiency of UGA recoding...
  11. ncbi Selenoprotein expression is regulated at multiple levels in prostate cells
    Cheryl M Rebsch
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ--Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Res 16:940-8. 2006
    ..These results demonstrate that selenoproteins and selenium metabolism are regulated at multiple levels in prostate cells...
  12. ncbi Efficiency of mammalian selenocysteine incorporation
    Anupama Mehta
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:37852-9. 2004
    ..The significance of these findings with regard to the function of known Sec incorporation factors is discussed...
  13. ncbi Mechanism and regulation of selenoprotein synthesis
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Annu Rev Nutr 23:17-40. 2003
    ..The efficiency and regulation of mammalian selenoprotein synthesis are considered in the context of current models for Sec insertion...
  14. ncbi Purification and analysis of selenocysteine insertion sequence-binding protein 2
    Paul R Copeland
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Methods Enzymol 347:40-9. 2002

Research Grants14

  1. Expanding The Genetic Code In Yeast
    Paul R Copeland; Fiscal Year: 2010
    ..In addition, this system will form the test bed for therapeutics agents designed to regulated the production of selenium-containing proteins in vivo. ..
  2. Functional analysis of SBP2 and selenocysteine incorporation
    Paul Copeland; Fiscal Year: 2009
    ..abstract_text> ..
  3. Functional analysis of SBP2 and selenocysteine incorporation
    Paul Copeland; Fiscal Year: 2007
    ..abstract_text> ..
  4. The translational control of selenoprotein synthesis
    Paul Copeland; Fiscal Year: 2007
    ..abstract_text> ..
  5. Functional analysis of SBP2 and selenocysteine incorporation
    Paul Copeland; Fiscal Year: 2007
    ....