G B Stefano

Summary

Affiliation: Neuroscience Research Institute
Country: USA

Publications

  1. ncbi Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review)
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 16:621-30. 2005
  2. ncbi Morphine modulation of the ubiquitin-proteasome complex is neuroprotective
    Suraj Rambhia
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury NY 11568, USA
    Med Sci Monit 11:BR386-96. 2005
  3. ncbi Homeopathic ethanol
    Richard M Kream
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 14:SC11-3. 2008
  4. ncbi Proinflammation and preconditioning protection are part of a common nitric oxide mediated process
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 16:RA125-30. 2010
  5. ncbi Immunocytes modulate ganglionic nitric oxide release which later affects their activity level
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Neuro Endocrinol Lett 25:57-61. 2004
  6. ncbi Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the micro(3) opiate receptor subtype: a hormonal role for endogenous morphine
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    J Physiol Pharmacol 55:279-88. 2004
  7. ncbi Nitric oxide modulates microglial activation
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, U S A
    Med Sci Monit 10:BR17-22. 2004
  8. ncbi 17-beta estradiol down regulates ganglionic microglial cells via nitric oxide release: presence of an estrogen receptor beta transcript
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 24:130-6. 2003
  9. ncbi Endocannabinoids as autoregulatory signaling molecules: coupling to nitric oxide and a possible association with the relaxation response
    George B Stefano
    The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Med Sci Monit 9:RA63-75. 2003
  10. ncbi Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, New York 11568, USA
    Endocrinology 144:1234-40. 2003

Research Grants

  1. Old Westbury Neuroscience Research Institute MIDARP
    George Stefano; Fiscal Year: 2007

Detail Information

Publications104 found, 100 shown here

  1. ncbi Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review)
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 16:621-30. 2005
    ..We conclude that constitutive nitric oxide may crucially contribute to potentially beneficial outcomes and effects in diverse pathologies, exerting a global healing effect...
  2. ncbi Morphine modulation of the ubiquitin-proteasome complex is neuroprotective
    Suraj Rambhia
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury NY 11568, USA
    Med Sci Monit 11:BR386-96. 2005
    ....
  3. ncbi Homeopathic ethanol
    Richard M Kream
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 14:SC11-3. 2008
    ..Perturbation of this subtle regulatory relationship by exogenous intake of ethanol may shed light on the biochemical and molecular bases of reward and addictive states...
  4. ncbi Proinflammation and preconditioning protection are part of a common nitric oxide mediated process
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 16:RA125-30. 2010
    ..Simultaneously, preconditioning protection counter-intuitively may rely on the same molecular process involving nitric oxide as a chemical messenger...
  5. ncbi Immunocytes modulate ganglionic nitric oxide release which later affects their activity level
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Neuro Endocrinol Lett 25:57-61. 2004
    ....
  6. ncbi Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the micro(3) opiate receptor subtype: a hormonal role for endogenous morphine
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    J Physiol Pharmacol 55:279-88. 2004
    ..Taken together, we surmise morphine acts as a hormone to limit gut activity via micro(3) coupled to NO release since micro opiate receptors are found in the gut and endogenous morphine is not but is found in blood...
  7. ncbi Nitric oxide modulates microglial activation
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, U S A
    Med Sci Monit 10:BR17-22. 2004
    ..Little is known about the processes in neural tissues, which stabilize microglia. This study attempts to answer this question by demonstrating a role for basal NO in maintaining microglia juxtaposed to neurons...
  8. ncbi 17-beta estradiol down regulates ganglionic microglial cells via nitric oxide release: presence of an estrogen receptor beta transcript
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 24:130-6. 2003
    ..We also demonstrated the presence of estrogen signaling in Mytilus edulis ganglia. In the present report, we sought to determine a function for these ganglionic estrogen receptors, transcending a reproductive role for estrogen...
  9. ncbi Endocannabinoids as autoregulatory signaling molecules: coupling to nitric oxide and a possible association with the relaxation response
    George B Stefano
    The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Med Sci Monit 9:RA63-75. 2003
    ..e, norepinephrine. Here, a possible association of NO and endocannabinoid signaling with the relaxation response, a physiological counterpart of the stress response, may exist...
  10. ncbi Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, New York 11568, USA
    Endocrinology 144:1234-40. 2003
    ..In summary, our results suggest that a physiological dose of estrogen acutely stimulates NO release within pedal ganglia via an estrogen cell surface receptor...
  11. ncbi Pain, immunity, opiate and opioid compounds and health
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Med Sci Monit 11:MS47-53. 2005
    ..Thus, morphine down regulates immune processes in addiction, an action/function that it appears to normally perform when the situation calls for this action and by so doing in this natural setting, sustains life...
  12. ncbi Music as an aid in the development of the social self
    Elliott Salamon
    The Long Island Conservatory, Albertson, NY, USA
    Med Sci Monit 8:SR35-8. 2002
    ..Specifically we propose that participation in musical or band related activities aids in the emergence of adolescence independence and a healthy self concept...
  13. ncbi Communication between animal cells and the plant foods they ingest: phyto-zooidal dependencies and signaling (Review)
    George B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, USA
    Int J Mol Med 10:413-21. 2002
    ....
  14. ncbi Cyclic nitric oxide release by human granulocytes, and invertebrate ganglia and immunocytes: nano-technological enhancement of amperometric nitric oxide determination
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568 0210, USA
    Med Sci Monit 8:BR199-204. 2002
    ..Various tissues from vertebrates and invertebrates respond to external signal molecules by rapid release of nitric oxide (NO) mediated by constitutive nitric oxide synthase...
  15. ncbi The blueprint for stress can be found in invertebrates
    George B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 23:85-93. 2002
    ..Thus, it would appear that these responses evolved first in simpler organisms and were then maintained and enhanced during evolution...
  16. ncbi Music alters constitutively expressed opiate and cytokine processes in listeners
    George B Stefano
    Long Island Conservatory, Albertson, NY, U S A
    Med Sci Monit 10:MS18-27. 2004
    ..Although these effects are robust, little research has been conducted into exploring the underlying neurochemical changes, which must occur to provide an individual with these objective sensations...
  17. ncbi Role of amygdala in mediating sexual and emotional behavior via coupled nitric oxide release
    Elliott Salamon
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, New York 11568, USA
    Acta Pharmacol Sin 26:389-95. 2005
    ..We begin with a brief anatomical and functional review of amygdalar function, and then proceed to demonstrate its relationship with NO...
  18. ncbi Regulation of various genes in human leukocytes acutely exposed to morphine: expression microarray analysis
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Med Sci Monit 11:MS35-42. 2005
    ..This novel micro receptor is selective for the opiate alkaloid morphine, since this receptor does not bind other opioid peptides...
  19. ncbi Dopamine, morphine, and nitric oxide: an evolutionary signaling triad
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, USA
    CNS Neurosci Ther 16:e124-37. 2010
    ..Our compelling hypothesis promises to initiate the reexamination of clinical studies, adding new information and treatment modalities in biomedicine...
  20. ncbi Revisiting tolerance from the endogenous morphine perspective
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 15:RA189-98. 2009
    ..In other words, we become satisfied with sex, food, pleasure for the moment and disinterest creeps in until the "urges" return...
  21. ncbi Xenobiotic perturbation of endogenous morphine signaling: paradoxical opiate hyperalgesia
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury NY 11568, USA
    Med Sci Monit 15:RA107-10. 2009
    ....
  22. ncbi The presence of endogenous morphine signaling in animals
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, P O Box 210, Old Westbury, NY 11568, USA
    Neurochem Res 33:1933-9. 2008
    ....
  23. ncbi Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: implications for cancer biology
    George B Stefano
    Neuroscience Research Institute, State University of New York SUNY College at Old Westbury, P O Box 210, Old Westbury, NY 11568, USA
    Semin Cancer Biol 18:199-210. 2008
    ..Thus, it would appear that morphinergic signaling has inserted itself in many processes taking a long time to evolve, including those regulating the proliferation of cells across diverse phyla...
  24. ncbi Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Semin Cancer Biol 18:190-8. 2008
    ..Finally, structural similarities between the intracellular domains of mu3 opiate receptors and chemokine receptors CCR2 and CCR5 provide an additional chemical basis for these contentions...
  25. ncbi Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review)
    George B Stefano
    Neuroscience Research Institute, SUNY College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 20:837-41. 2007
    ....
  26. ncbi Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 13:RA91-102. 2007
    ..Additionally, addictive drugs are capable of directly acting on reward pathways, now, in part, via endogenous morphine processes...
  27. ncbi Relaxation: molecular and physiological significance
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:HY21-31. 2006
    ..We conclude that enough scientific information exists to support these phenotmena as actual physical processes that can be harnessed to provide better patient care...
  28. ncbi Reciprocal regulation of cellular nitric oxide formation by nitric oxide synthase and nitrite reductases
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 17:RA221-6. 2011
    ..The profound implications of a reciprocal regulatory mechanism responsible for cytosolic and mitochondrial NO production are discussed below...
  29. ncbi A hormonal role for endogenous opiate alkaloids: vascular tissues
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 23:21-6. 2002
    ..With this in mind, morphine and other endogenous opiate alkaloids may function as a hormone...
  30. ncbi Anticipatory stress response: a significant commonality in stress, relaxation, pleasure and love responses
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 14:RA17-21. 2008
    ..Therefore, love and relaxation responses may be considered as intrinsic health promoting physiological capabilities...
  31. ncbi Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York, Old Westbury 11568, USA
    J Immunol 163:3758-63. 1999
    ..Taken together, a physiological dose of estrogen acutely stimulates NO release from human monocytes via the activation of an estrogen surface receptor that is coupled to increases in intracellular calcium...
  32. ncbi Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Int J Cardiol 64:S3-13. 1998
    ..Thus. the chemokinetic inducing activities of these agents may be the basis for excitotoxin liberation in neural tissues and/or a higher viral load in various organ systems since cellular adherence and random migration are stimulated...
  33. ncbi Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation
    G B Stefano
    Cardiac Research Program, University Medical Center, State University of New York, Stony Brook 11794, USA
    J Biol Chem 270:30290-3. 1995
    ..In conclusion, the data presented above reveal a novel site of morphine action, endothelial cells, where a mu3 receptor is coupled to nitric oxide release and vasodilation...
  34. ncbi Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Brain Res 763:63-8. 1997
    ..We postulate that cannabinoids and their endogenous effectors play a prominent role in the regulation of catecholamine release in invertebrates via NO release as is the case for opiate alkaloids...
  35. ncbi Morphine coupling to invertebrate immunocyte nitric oxide release is dependent on intracellular calcium transients
    F E Nieto-Fernandez
    Neuroscience Research Institute, State University of New York at Old Westbury 11568 0210, USA
    Comp Biochem Physiol B Biochem Mol Biol 123:295-9. 1999
    ..The opiate stimulation of [Ca2+]i- was attenuated in cells leached of calcium. strongly suggesting that intracellular calcium levels regulate cNOS activity in invertebrate immunocytes...
  36. ncbi 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Pharmacol Res 42:317-22. 2000
    ..Taken together these results indicate that 2-AG exerts immune and vascular actions similar to those observed with anandamide...
  37. ncbi Nociceptin, endomorphin-1 and -2 do not interact with invertebrate immune and neural mu 3 opiate receptor
    C M Rialas
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Acta Pharmacol Sin 21:516-20. 2000
    ..To determine if endomorphin-1, -2 and nociceptin (orphanin FQ) bind to the mu 3 opiate receptor subtype or release nitric oxide as mu 3 selective ligands do...
  38. ncbi Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568, USA
    Brain Res 753:219-24. 1997
    ..The presence of a cannabinoid receptor in these organisms indicates that this signaling system has been conserved during evolution...
  39. ncbi Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Addict Biol 13:118-23. 2008
    ..Taken together, it appears that morphine has the ability to modulate its own synthesis via autocrine and paracrine signaling...
  40. ncbi The presence of morphine in ganglionic tissues of Modiolus deminissus: a highly sensitive method of quantitation for morphine and its derivatives
    Y Goumon
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 86:184-8. 2001
    ..Furthermore, both morphine and morphine-6-glucuronide were identified in this mollusk's pedal ganglia by mass spectrometry analysis...
  41. ncbi Cell behavior and signal molecule involvement in a case study of malignant histiocytosis: a negative model of morphine as an immunoregulator
    G L Fricchione
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hematol 56:197-205. 1997
    ..Additionally, the data indicate that MCSF deregulation may be involved as an initiating factor for this disorder...
  42. ncbi Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 7:419-22. 2001
    ..14 da) yields morphine (286.14 Da) obtained from the heart tissues and with the authentic material, further demonstrating the presence of endogenous morphine. Thus, vascular tissues appear to contain endogenous opiate alkaloids...
  43. ncbi Cell surface estrogen receptors coupled to cNOS mediate immune and vascular tissue regulation: therapeutic implications
    G B Stefano
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 7:1066-74. 2001
    ....
  44. ncbi Psychiatric implications of endogenous morphine: up-to-date review
    R M Kream
    Neuroscience Research Institute, State University of New York at Old Westbury, New York 11568, USA
    Folia Biol (Praha) 56:231-41. 2010
    ....
  45. ncbi Real-time RT-PCR measurement of the modulation of Mu opiate receptor expression by nitric oxide in human mononuclear cells
    P Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, New York 11568-0210, USA
    Med Sci Monit 7:1123-8. 2001
    ..CONCLUSIONS: This study confirms that human mononuclear cells express the mu opiate receptor transcript and demonstrates that nitric oxide is involved in regulation of its expression...
  46. ncbi Invertebrate opiate immune and neural signaling
    George B Stefano
    Neuroscience Research Institute, State University of New York, Old Westbury, USA
    Adv Exp Med Biol 521:126-47. 2003
  47. ncbi Morphine 6 glucuronide stimulates nitric oxide release in mussel neural tissues: evidence for a morphine 6 glucuronide opiate receptor subtype
    K Mantione
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568, USA
    Cell Mol Life Sci 59:570-4. 2002
    ..However, morphine exhibited a twofold higher affinity, again suggesting that a novel mu opiate receptor may be present...
  48. ncbi Cholinergic regulation of morphine release from human white blood cells: evidence for a novel nicotinic receptor via pharmacological and microarray analysis
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Immunopathol Pharmacol 20:229-37. 2007
    ..The number of variants suggests that indeed a novel nicotinic receptor may be mediating this effect, while simultaneously demonstrating the significance of the cholinergic receptor expression in these immune cells...
  49. ncbi Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 793:341-5. 1998
    ..2+/-1.3 nM to 8.6+/-2.1 nM. Taken together, the results indirectly demonstrate the presence of anandamide amidase in these tissues, suggesting that the enzyme may serve as an endogenous regulator of anandamide action...
  50. ncbi Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Blood 95:3951-8. 2000
    ..Blood. 2000;95:3951-3958)..
  51. ncbi The stress response and autoimmunoregulation
    G L Fricchione
    Division of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Adv Neuroimmunol 4:13-27. 1994
    ..The study of immunocyte behavior in certain clinical conditions associated with a variant stress response may help illuminate the functioning of the neuroendocrine-neuroimmune stress response system...
  52. ncbi Presence of morphine and morphine-6-glucuronide in the marine mollusk Mytilus edulis ganglia determined by GC/MS and Q-TOF-MS. Starvation increases opiate alkaloid levels
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 88:155-60. 2001
    ..These new method of opiate alkaloid detection, conclusively proves that morphine and morphine-6-glucuronide are present in animal tissues...
  53. ncbi HIV gp120 and morphine alter mu opiate receptor expression in human vascular endothelium
    P Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 8:165-9. 2001
    ..Therefore, the immune down-regulating action of morphine may prevent viral replication because this process requires immune activation that can, in part, be provided for by gp120 proinflammatory actions...
  54. ncbi Morphine down regulates human vascular tissue estrogen receptor expression determined by real-time RT-PCR
    Patrick Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 23:95-100. 2002
    ..CONCLUSIONS: These results indicate that ER-beta is expressed in human vascular endothelial cells, and morphine appears to regulate this receptor in a similar fashion as the mu opiate receptor...
  55. ncbi Endogenous morphine: opening new doors for the treatment of pain and addiction
    Stephen C Pryor
    State University of New York--College at Old Westbury, Neuroscience Research Institute, Old Westbury, NY 11568, USA
    Expert Opin Biol Ther 5:893-906. 2005
    ..Taken together, a select morphinergic signalling system utilising NO opens the gate for the development of novel pharmaceuticals and/or the use of old pharmaceuticals in new ways...
  56. ncbi Endogenous morphinergic signaling and tumor growth
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568-0210, USA
    Front Biosci 9:3176-86. 2004
    ..This review will focus on the influence of opiate alkaloids, e.g., morphine, on tumor growth, with emphasis on immuno-regulatory and antiproliferative mechanisms...
  57. ncbi Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries
    Gregory Fricchione
    Department of Psychiatry, Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, 02114, USA
    Med Sci Monit 11:MS54-65. 2005
    ..In addition, mesolimbic/mesocortical control of the stress response systems may provide a way for the placebo response to benefit other medical conditions...
  58. ncbi TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues
    Jeanette Cheng
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 13:BR163-7. 2007
    ..An extremely promising method for treatment of low to moderate levels of chronic pain in humans is transcutaneous electrical nerve stimulation (TENS)...
  59. ncbi Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568 0210, USA
    Prog Neurobiol 60:513-30. 2000
    ..Taken together, cNOS derived NO enhances basal NO actions, i.e., cellular activation state, and these actions are further enhanced by iNOS derived NO...
  60. ncbi Dracunculus medinensis and Schistosoma mansoni contain opiate alkaloids
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Ann Trop Med Parasitol 96:309-16. 2002
    ....
  61. ncbi Nitric oxide inhibits norepinephrine stimulated contraction of human internal thoracic artery and rat aorta
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Westbury NY, 11568, USA
    Pharmacol Res 43:199-203. 2001
    ....
  62. ncbi The American lobster, Homarus americanus, contains morphine that is coupled to nitric oxide release in its nervous and immune tissues: Evidence for neurotransmitter and hormonal signaling
    Federico M Casares
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 26:89-97. 2005
    ..CONCLUSION: Taken together, after eliminating all sources of contamination, morphine is present in lobster tissues, potentially demonstrating hormonal and neurotransmitter functions that are involved in the animals' stress response...
  63. ncbi The nongenomic protective effects of estrogen on the male cardiovascular system: clinical and therapeutic implications in aging men
    John J Cho
    Neuroscience Research Institute State University of New York Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 9:RA63-8. 2003
    ..Therapeutic strategies to preserve basal nitric oxide levels through the maintenance of normal physiological estradiol levels may confer cardiovascular benefits to aging males...
  64. ncbi Alcohol-, nicotine-, and cocaine-evoked release of morphine from invertebrate ganglia: model system for screening drugs of abuse
    Wei Zhu
    Neuroscience Research Institute, State University of New York - College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR155-61. 2006
    ..The evolutionary conservation of L-tyrosine as a common precursor to catecholamine and opiate/opioid signaling systems may define a functional triad involving endogenous morphine, dopamine, and other classes of addictive drugs...
  65. ncbi The biochemical substrate of nitric oxide signaling is present in primitive non-cognitive organisms
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 924:82-9. 2002
    ..We conclude that basal nitric oxide functioning was established in these organisms and that this molecule was later employed in man, including its involvement in cognitive neural processes...
  66. ncbi Opiate alkaloids and nitric oxide production in the nematode Ascaris suum
    Wei Zhu
    State University of New York, Old Westbury Neuroscience Research Institute, P.O. Box 210, Old Westbury, New York 11568, USA
    J Parasitol 90:15-22. 2004
    ..This suggests that a novel mu opiate receptor was possibly present and selective toward M6G...
  67. ncbi Presence of reticuline in rat brain: a pathway for morphine biosynthesis
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 117:83-90. 2003
    ..This finding adds information which suggests that morphine biosynthesis may occur in rat neural tissues, and that its biosynthesis pathway may be similar to that reported in the poppy plant...
  68. ncbi Ischemic preconditioning - an opiate constitutive nitric oxide molecular hypothesis
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Med Sci Monit 7:1357-75. 2001
    ..In conclusion, it appears as though endogenous nitric oxide stimulators offer their selective preconditioning protection by joining an already existing process that limits activation following normal physical exertion...
  69. ncbi Morphine regulates gill ciliary activity via coupling to nitric oxide release in a bivalve mollusk: opiate receptor expression in gill tissues
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR195-200. 2006
    ..We hypothesized that morphinergic signaling may also take place in Mytilus edulis gill since they are innervated, in part, with dopamine nerves...
  70. ncbi Cholinergic regulation of endogenous morphine release from lobster nerve cord
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, P O Box 210, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR295-301. 2006
    ..Thus, invertebrate nervous tissue preparations can be used as predictive model systems by which to evaluate underlying pharmacological mechanisms of addictive processes...
  71. ncbi Comparative aspects of endogenous morphine synthesis and signaling in animals
    Wei Zhu
    Neuroscience Research Institute, College at Old Westbury, State University of New York, Old Westbury, New York, USA
    Ann N Y Acad Sci 1163:330-9. 2009
    ....
  72. ncbi Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes
    Richard M Kream
    Neuroscience Research Institute, State University of New York, College at Old Westbury, NY 11568, USA
    Med Sci Monit 15:RA263-8. 2009
    ..Critical to this concept may be the phenomenon of mitochondrial enslavement in eukaryotic evolution via morphine...
  73. ncbi Alcohol-, nicotine-, and cocaine-evoked release of morphine from human white blood cells: substances of abuse actions converge on endogenous morphine release
    Wei Zhuu
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR350-4. 2006
    ..Furthermore, invertebrate neural tissues incubated with ethanol, cocaine, or nicotine results in a statistically significant enhancement of labeled morphine release. We now demonstrate that this also occurs with human WBC...
  74. ncbi Identification of a µ opiate receptor signaling mechanism in human placenta
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY, USA
    Med Sci Monit 16:BR347-52. 2010
    ..We determined if a µ opiate receptor was present and which subtype was expressed in human placenta. We also sought to demonstrate a functional µ opiate receptor in human placenta...
  75. ncbi Cold stress alters Mytilus edulis pedal ganglia expression of mu opiate receptor transcripts determined by real-time RT-PCR and morphine levels
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568-0210, USA
    Brain Res Mol Brain Res 99:26-33. 2002
    ..This study provides further evidence that mu-type opiate receptors and morphine are expressed in mollusk ganglia and appear to be involved in physiological processes responding to thermal stress...
  76. ncbi Differential expression of the human mu opiate receptor from different primary vascular endothelial cells
    Patrick Cadet
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 10:BR351-5. 2004
    ..This novel mu receptor has been shown to be selective for opiate alkaloids, insensitive to opioid peptides, and also is coupled to constitutive nitric oxide release...
  77. ncbi Effects of cold stress on morphine-induced nitric oxide production and mu-opiate receptor gene expression in Mytilus edulis pedal ganglia
    Kirk Mantione
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568-0210, USA
    Neuro Endocrinol Lett 24:68-72. 2003
    ..7 +/- 4.9 nM NO, which was a statistically significant difference between 25 degrees C and 4 degrees C animals (p=0.025). CONCLUSION: The study further demonstrates that mu opiate receptor expression is coupled to NO release...
  78. ncbi Pain and relaxation (review)
    Elliott Salamon
    Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, USA
    Int J Mol Med 18:465-70. 2006
    ..We further propose a new paradigm which links pain, endogenous opiates, and the catecholamines in a unique robust fashion demonstrating a complex symbiotic signaling system...
  79. ncbi The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide
    G B Stefano
    The Mind Body Medical Institute, CareGroup, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115, Boston, MA, USA
    Brain Res Brain Res Rev 35:1-19. 2001
    ..In closing, we conclude that enough scientific information exists to support these phenomena as actual physical processes that can be harnessed to provide better patient care...
  80. ncbi Human white blood cells synthesize morphine: CYP2D6 modulation
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    J Immunol 175:7357-62. 2005
    ..3) WBC can release morphine into the environment to regulate themselves and other cells, suggesting involvement in autocrine signaling since these cells express the mu3 opiate receptor subtype...
  81. ncbi Reticuline exposure to invertebrate ganglia increases endogenous morphine levels
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 25:323-30. 2004
    ..CONCLUSION: Taken together, we surmise that the morphine's precursors are being converted to morphine. The experiments strongly indicate that pedal ganglia can synthesize morphine from reticuline...
  82. ncbi Converging cellular processes for substances of abuse: endogenous morphine
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 29:63-6. 2008
    ....
  83. ncbi Cyclic exercise induces anti-inflammatory signal molecule increases in the plasma of Parkinson's patients
    Patrick Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 12:485-92. 2003
    ....
  84. ncbi Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, New York 11568, USA
    Med Sci Monit 11:BR397-404. 2005
    ..This process also appears to be dynamic in that the inhibition of one pathway allows the other to continue with morphine synthesis. Moreover, dopamine and morphine synthesis were coupled...
  85. ncbi The presence of the mu3 opiate receptor in invertebrate neural tissues
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury 11568, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 113:369-73. 1996
    ..This view is supported by additional data, in particular the demonstration of endogenous morphine in nervous tissue and its localization within distinct neurons...
  86. ncbi Vascular pulsations stimulating nitric oxide release during cyclic exercise may benefit health: a molecular approach (review)
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 7:119-29. 2001
    ..We conclude that mild exercise represents an alternate and economical therapy to preserve health and/or diminish the rate of decline of the normal physiological processes that may even be associated with aging...
  87. ncbi Persistence of evolutionary memory: primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling
    Richard M Kream
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 13:SC5-6. 2007
    ....
  88. ncbi Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, P O Box 210, Old Westbury, New York 11568, USA
    Cell Mol Neurobiol 26:1037-45. 2006
    ..5. We surmise that norlaudanosoline is being converted to morphine, demonstrating that invertebrate neural tissue can synthesize morphine...
  89. ncbi Presence of morphine in rat amygdala: evidence for the mu3 opiate receptor subtype via nitric oxide release in limbic structures
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568-0210, USA
    Med Sci Monit 10:BR433-9. 2004
    ..Given the limbic system involvement in modulating emotion, including experiences related to pain perception, it appears that morphine is involved with this activity...
  90. ncbi The presence of 17-beta estradiol in Mytilus edulis gonadal tissues: evidence for estradiol isoforms
    Wei Zhu
    Neuroscience Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 24:137-40. 2003
    ..This further suggests that estrogen's association with reproductive activities has a long evolutionary history and that this association began in invertebrates...
  91. ncbi The therapeutic use of the relaxation response in stress-related diseases
    Tobias Esch
    The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Med Sci Monit 9:RA23-34. 2003
    ..Further studies are necessary to elucidate the complex physiology underlying the RR and its impact upon stress-related disease states...
  92. ncbi Risk factors for breast cancer and the prognosis of African American women: estrogen's role
    Dolisha A Jones
    Neuroscience Research Institute, State University of New York College at Old Westbury, U S A
    Med Sci Monit 9:RA111-9. 2003
    ..By determining the relative concentration of estrogen and related proteins within black and white populations we hope to better understand the above mentioned disparity...
  93. ncbi Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release
    C Fimiani
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Cancer Lett 146:45-51. 1999
    ..Our findings identify a unique role for the mu3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression...
  94. ncbi Neuroimmunologic influences in neuropsychiatric and psychophysiologic disorders
    G Fricchione
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acta Pharmacol Sin 22:577-87. 2001
    ..This may provide new strategies for pharmacologic anti inflammatory treatments. The monocyte /macrophage, which crosses the blood brain barrier is an essential candidate cell in the study of psychoneuroimmunology...
  95. ncbi Variations in critical morphine biosynthesis genes and their potential to influence human health
    Kirk Mantione
    St Elizabeth s University College of Health and Social Sciences, School of Public Health, Clinical Medicine Program, Bratislava, Slovakia
    Neuro Endocrinol Lett 31:11-8. 2010
    ..The presence of morphine signaling in almost all organ systems suggests that it is most likely playing a role in maintaining the health and promoting the normal functioning of these physiological systems...
  96. ncbi Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, Old Westbury, NY 11568, USA
    J Immunol 170:5118-23. 2003
    ..Furthermore, using Northern blot, RT-PCR, and sequence analysis, we have demonstrated the expression of this new mu variant in human vascular tissue, mononuclear cells, polymorphonuclear cells, and human neuroblastoma cells...
  97. ncbi Signaling pathway of morphine induced acute thermal hyperalgesia in mice
    Nicoletta Galeotti
    Department of Clinical and Preclinical Pharmacology, University of Florence, Florence, Italy
    Pain 123:294-305. 2006
    ..The clinical management of pain by morphine may be revisited in light of the identification of the signaling molecules of the hyperalgesic pathway...
  98. ncbi Commonalities in the central nervous system's involvement with complementary medical therapies: limbic morphinergic processes
    Tobias Esch
    , Institute for General and Family Medicine, Berlin, Germany
    Med Sci Monit 10:MS6-17. 2004
    ..However, molecular correspondents of the detected CNS analogies still have to be specified. In particular, fast acting autoregulatory signaling molecules presumably play a role. These may also be involved in the placebo response...
  99. ncbi Direct assessment and diminished production of morphine stimulated NO by diabetic endothelium from saphenous vein
    Thomas V Bilfinger
    Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19 080, Stony Brook, New York 11794 8191, USA
    Acta Pharmacol Sin 23:97-102. 2002
    ..To directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the mu opiate receptor, which has been linked with NO release...
  100. ncbi Neurotransmitter role of endogenous morphine in CNS
    Massimo Guarna
    Department of Anatomical and Biomedical Sciences, University of Siena, Italy
    Med Sci Monit 11:RA190-193. 2005
    ..Evidence has been found for its endogenous synthesis in animal tissues as well. These findings indicate that endogenous morphine might function as neuromodulator/neurotransmitter agent in the CNS...

Research Grants2

  1. Old Westbury Neuroscience Research Institute MIDARP
    George Stefano; Fiscal Year: 2007
    ..abstract_text> ..