R Kopke

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. ncbi A radical demise. Toxins and trauma share common pathways in hair cell death
    R Kopke
    DoD Spatial Orientation Center, Naval Medical Center, San Diego, California 92134, USA
    Ann N Y Acad Sci 884:171-91. 1999
  2. ncbi Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss
    Richard D Kopke
    Department of Defence Spatial Orientation Center, Naval Medical Center San Diego, California 92134, USA
    Laryngoscope 112:1515-32. 2002
  3. ncbi Distribution of PLGA nanoparticles in chinchilla cochleae
    Xianxi Ge
    Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 5000, USA
    Otolaryngol Head Neck Surg 137:619-23. 2007
  4. ncbi Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Acta Otolaryngol 127:914-9. 2007
  5. ncbi Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant
    Richard D Kopke
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Audiol Neurootol 11:123-33. 2006
  6. ncbi The early kinetics of gentamicin uptake into the inner ear
    Michael E Hoffer
    Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Int Tinnitus J 8:27-9. 2002
  7. ncbi Transtympanic management of tinnitus
    Michael E Hoffer
    Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Otolaryngol Clin North Am 36:353-8. 2003
  8. ncbi Vestibular testing abnormalities in individuals with motion sickness
    Michael E Hoffer
    Department of Defense, Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Otol Neurotol 24:633-6. 2003
  9. ncbi Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla
    Chul Hee Choi
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Free Radic Biol Med 44:1772-84. 2008
  10. ncbi Effect of trans-bullar gentamicin treatment on guinea pig angular and linear vestibulo-ocular reflexes
    Gavin E G Jones
    Department of Defense Spatial Orientation Center, Otolaryngology Department, Naval Medical Center, San Diego, 34800 Bob Wilson Dr. Ste 200, CA 92134, San Diego, USA
    Exp Brain Res 152:293-306. 2003

Detail Information

Publications11

  1. ncbi A radical demise. Toxins and trauma share common pathways in hair cell death
    R Kopke
    DoD Spatial Orientation Center, Naval Medical Center, San Diego, California 92134, USA
    Ann N Y Acad Sci 884:171-91. 1999
    ..Finally, examples of novel therapeutic strategies to prevent and reverse hearing loss due to noise and/or ototoxins are presented to illustrate the clinical relevance of these new findings...
  2. ncbi Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss
    Richard D Kopke
    Department of Defence Spatial Orientation Center, Naval Medical Center San Diego, California 92134, USA
    Laryngoscope 112:1515-32. 2002
    ..The objective of this study was to document the reduction in noise-induced hearing and hair cell loss, following application of ALCAR, carbamathione, and a GSH repletion drug D-methionine (MET), to a model of noise-induced hearing loss...
  3. ncbi Distribution of PLGA nanoparticles in chinchilla cochleae
    Xianxi Ge
    Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 5000, USA
    Otolaryngol Head Neck Surg 137:619-23. 2007
    ..To study the distribution of polylactic/glycolic acid-encapsulated iron oxide nanoparticles (PLGA-NPs) in chinchilla cochleae after application on the round window membrane (RWM)...
  4. ncbi Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Acta Otolaryngol 127:914-9. 2007
    ..The studies further reveal the potential for the use of NAC in a clinical population exposed to noise...
  5. ncbi Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant
    Richard D Kopke
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Audiol Neurootol 11:123-33. 2006
    ..A sinusoidal magnetic field applied to guinea pigs with SNP implanted in the middle ear resulted in displacements of the middle ear comparable to 90 dB SPL...
  6. ncbi The early kinetics of gentamicin uptake into the inner ear
    Michael E Hoffer
    Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Int Tinnitus J 8:27-9. 2002
    ..The information gained from this study may increase our scientific understanding about the effects of gentamicin on the inner ear and may allow clinicians to treat patients more effectively for inner-ear disorders...
  7. ncbi Transtympanic management of tinnitus
    Michael E Hoffer
    Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Otolaryngol Clin North Am 36:353-8. 2003
    ..Ideally in the future with knowledge of the disease and its etiology the physician will simply pick the established medicine, the established dose, and the established route of administration and achieve a relatively predictable result...
  8. ncbi Vestibular testing abnormalities in individuals with motion sickness
    Michael E Hoffer
    Department of Defense, Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Otol Neurotol 24:633-6. 2003
    ..The goal of this study was to compare the results of vestibular testing in individuals with motion sickness to a group of control subjects...
  9. ncbi Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla
    Chul Hee Choi
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Free Radic Biol Med 44:1772-84. 2008
    ..These results demonstrate that 4-OHPBN and combinations of antioxidants can effectively treat acute acoustic trauma and drug combinations may increase the effectiveness of treatment and decrease the required individual medication dose...
  10. ncbi Effect of trans-bullar gentamicin treatment on guinea pig angular and linear vestibulo-ocular reflexes
    Gavin E G Jones
    Department of Defense Spatial Orientation Center, Otolaryngology Department, Naval Medical Center, San Diego, 34800 Bob Wilson Dr. Ste 200, CA 92134, San Diego, USA
    Exp Brain Res 152:293-306. 2003
    ..It is suggested that these effects indicate selective cytotoxic and/or physiologic effects of gentamicin intoxication in the inner ear or, possibly, the vestibular nerve and central nervous system...
  11. ncbi NAC for noise: from the bench top to the clinic
    Richard D Kopke
    Hough Ear Institute, 3400 N W 56th Street, Oklahoma City, OK 73112, USA
    Hear Res 226:114-25. 2007
    ..Early clinical trials with NAC are mentioned...