Jonathan W Yewdell

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Youth has its privileges: maturation inhibits DC cross-priming
    Heather D Hickman-Miller
    Nat Immunol 7:125-6. 2006
  2. ncbi Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Annu Rev Immunol 23:651-82. 2005
  3. ncbi Quantitating defective ribosome products
    Shu-Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 301:271-81. 2005
  4. ncbi The seven dirty little secrets of major histocompatibility complex class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Immunol Rev 207:8-18. 2005
  5. ncbi Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA
    Proc Natl Acad Sci U S A 102:12649-50. 2005
  6. ncbi The DRiP hypothesis decennial: support, controversy, refinement and extension
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Trends Immunol 27:368-73. 2006
  7. ncbi How to succeed in science: a concise guide for young biomedical scientists. Part II: making discoveries
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:491-4. 2008
  8. ncbi How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:413-6. 2008
  9. ncbi CD8+ T cell cross-priming via transfer of proteasome substrates
    Christopher C Norbury
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892-0440, USA
    Science 304:1318-21. 2004
  10. ncbi Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products
    Shu-Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:227-33. 2006

Collaborators

Detail Information

Publications83

  1. ncbi Youth has its privileges: maturation inhibits DC cross-priming
    Heather D Hickman-Miller
    Nat Immunol 7:125-6. 2006
  2. ncbi Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0440, USA
    Annu Rev Immunol 23:651-82. 2005
    ..These studies point the way to detailed understanding and provide some key information for vaccine development, although much remains to be learned to enable truly rational vaccine design...
  3. ncbi Quantitating defective ribosome products
    Shu-Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 301:271-81. 2005
    ..Protein degradation kinetics can be determined by either acid precipitation or SDS-PAGE. The introduction of proteasome inhibitors enables quantitation of proteasome-mediated protein degradation in vivo...
  4. ncbi The seven dirty little secrets of major histocompatibility complex class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Immunol Rev 207:8-18. 2005
    ..Here, I discuss some of the DLSs of major histocompatibility complex class I antigen processing...
  5. ncbi Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA
    Proc Natl Acad Sci U S A 102:12649-50. 2005
  6. ncbi The DRiP hypothesis decennial: support, controversy, refinement and extension
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Trends Immunol 27:368-73. 2006
    ....
  7. ncbi How to succeed in science: a concise guide for young biomedical scientists. Part II: making discoveries
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:491-4. 2008
    ..Here, I provide practical advice to young scientists on choosing a research topic, designing, performing and interpreting experiments and, last but not least, on maintaining your sanity in the process...
  8. ncbi How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:413-6. 2008
    ..Although my advice is geared towards succeeding in the United States, many aspects apply to other countries...
  9. ncbi CD8+ T cell cross-priming via transfer of proteasome substrates
    Christopher C Norbury
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892-0440, USA
    Science 304:1318-21. 2004
    ..We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses...
  10. ncbi Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products
    Shu-Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:227-33. 2006
    ..We propose that specialized machinery exists to link protein synthesis with class I peptide ligand generation to enable the rapid detection of viral gene expression...
  11. ncbi Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 183:4205-10. 2009
    ..In demonstrating the dispensability of GRP94, our finding points to the importance of alternative mechanisms for generation of class I peptide complexes from endogenous and exogenous Ags and immunogens...
  12. ncbi Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:4115-22. 2010
    ..These findings demonstrate an important role for immunoproteasomes in immune cell function beyond their contribution to Ag processing...
  13. ncbi CD8 alpha alpha-mediated intraepithelial lymphocyte snatching of thymic leukemia MHC class Ib molecules in vitro and in vivo
    Nathalie Pardigon
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 177:1590-8. 2006
    ..Induction of bowel inflammation results in the presence of TL on IELs, probably via in vivo snatching, providing the initial evidence for the interaction of CD8alphaalpha IELs with intestinal cells...
  14. ncbi Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:1419-24. 2010
    ..These observations extend the relevance of the DRiP hypothesis to viral proteins generated in their natural context...
  15. ncbi RNA polymerase II inhibitors dissociate antigenic peptide generation from normal viral protein synthesis: a role for nuclear translation in defective ribosomal product synthesis?
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 185:6728-33. 2010
    ..These data support the idea that Ag processing uses compartmentalized translation, perhaps even in the nucleus itself, to increase the efficiency of the generation of class I peptide ligands...
  16. ncbi Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy
    Suman R Das
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:E1417-22. 2011
    ..These findings show that, although N-linked glycosylation can broadly diminish HA antigenicity, fitness costs restrict its deployment in immune evasion...
  17. ncbi Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:6964-9. 2010
    ..This provides an explanation for the exquisite ability of T cells to recognize peptides generated from otherwise undetected gene products...
  18. ncbi Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance
    Scott E Hensley
    Laboratory of Viral Diseases, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e15190. 2011
    ..These findings indicate that influenza A virus resistance to NA inhibitors can potentially arise from antibody driven HA escape, confounding analysis of influenza NA evolution in nature...
  19. ncbi Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Virol 80:6318-23. 2006
    ..We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus...
  20. ncbi Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Immunol 9:155-65. 2008
    ..Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8+ T cell activation...
  21. ncbi Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergies and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:3344-51. 2005
    ..Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants...
  22. ncbi Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:649-59. 2008
    ....
  23. ncbi Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis
    Kristie M Grebe
    Laboratories of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:540-4. 2010
    ..These findings demonstrate an unexpected role for the sympathetic nervous system in innate antiviral immunity and in exacerbating the pathology of a virus of great significance to human and animal health...
  24. ncbi Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
    David C Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:95-104. 2005
    ..These findings have important implications for understanding poxvirus immunity in animal models and bench-marking immune responses to poxvirus vaccines in humans...
  25. ncbi Heat-aggregated noninfectious influenza virus induces a more balanced CD8(+)-T-lymphocyte immunodominance hierarchy than infectious virus
    Yunjung Cho
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:4679-84. 2003
    ..Furthermore, they demonstrate that the form of antigen administered can influence immunodominance hierarchies and that exogenous-antigen vaccines can induce broad and balanced T(CD8+) responses...
  26. ncbi Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 326:734-6. 2009
    ....
  27. ncbi Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control
    Shu-Bing Qian
    Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892-0440, USA
    J Biol Chem 281:392-400. 2006
    ..The dichotomy in the behavior of RDPs points to a novel quality control level for nascent proteins that is independent of the well established Hsc70-ubiquitin 26 S proteasome pathway...
  28. ncbi Quantitating T cell cross-reactivity for unrelated peptide antigens
    Jeffrey Ishizuka
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda MD 20892, USA
    J Immunol 183:4337-45. 2009
    ....
  29. ncbi Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance
    Brian P Dolan
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:2065-72. 2011
    ....
  30. ncbi Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells
    Heather D Hickman
    Cell Biology and Viral Immunology Sections, Laboratory of Viral Diseases, 2 Biological Imaging Facility, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Exp Med 208:2511-24. 2011
    ..Thus, virus-induced chemokines in DLNs enable antiviral CD8(+) T cells to distinguish DCs from macrophages to optimize T cell priming...
  31. ncbi Quantitating protein synthesis, degradation, and endogenous antigen processing
    Michael F Princiotta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Immunity 18:343-54. 2003
    ....
  32. ncbi From optical bench to cageside: intravital microscopy on the long road to rational vaccine design
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 239:209-20. 2011
    ....
  33. ncbi RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes
    Alexandre David
    Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:20688-700. 2011
    ..S., Embry, A., Dolan, B., Das, S., Hickman, H. D., Berglund, P., Bennink, J. R., Yewdell, J. W., and Pan, T. (2009) Nature 462, 522-526) can be modulated at the level of individual mRNAs to modify decoding of specific gene products...
  34. ncbi Immunology. Hide and seek in the peptidome
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA
    Science 301:1334-5. 2003
  35. ncbi Sympathetic nervous system control of anti-influenza CD8+ T cell responses
    Kristie M Grebe
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:5300-5. 2009
    ....
  36. ncbi Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 21:149-53. 2004
    ....
  37. ncbi The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation
    Avital Lev
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 28:787-98. 2008
    ....
  38. ncbi Systematic search fails to detect immunogenic MHC class-I-restricted determinants encoded by influenza A virus noncoding sequences
    Weisan Chen
    Laboratory of Viral Diseases Natonal Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0440, USA
    Virology 305:50-4. 2003
    ..These findings suggest that alternative reading frames are not a significant source of antigenic peptides in influenza virus infections and raise doubts regarding the general biological significance of ARF determinants...
  39. ncbi Murine norovirus infection has no significant effect on adaptive immunity to vaccinia virus or influenza A virus
    Scott E Hensley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208921, USA
    J Virol 83:7357-60. 2009
    ....
  40. ncbi Proteasomes get by with lots of help from their friends
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 208920 USA
    Immunity 20:362-3. 2004
    ..Now it appears that another protease, tripeptidyl peptidase II (TPP II), plays a critical role in cleaving proteasomal produced peptides into shorter peptides that can then be degraded by aminopeptidases...
  41. ncbi Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
    Brian P Dolan
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Mol Life Sci 68:1481-9. 2011
    ....
  42. ncbi Nuclear translation visualized by ribosome-bound nascent chain puromycylation
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Cell Biol 197:45-57. 2012
    ..In this paper, we use the RPM to provide evidence for translation in the nucleoplasm and nucleolus, which is regulated by infectious and chemical stress...
  43. ncbi Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus
    Weisan Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, 4 Center Drive, Bethesda, MD 20892 0440, USA
    J Virol 76:10332-7. 2002
    ..This points to intrinsic features of the T(CD8+) repertoire as major contributors to immunodominance...
  44. ncbi Heterosubtypic immunity to influenza A virus: where do we stand?
    Kristie M Grebe
    Viral Immunology and Cellular Biology Sections, NIAID, National Institutes of Health, DHHS, Bethesda, MD 20892 3209, USA
    Microbes Infect 10:1024-9. 2008
    ..Here we review current knowledge of the mechanisms contributing to HSI to influenza and speculate on the potential for this approach to contribute to public health...
  45. ncbi Immune recognition of a human renal cancer antigen through post-translational protein splicing
    Ken ichi Hanada
    Surgery Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building10, Room 2B42, Bethesda, Maryland 20892, USA
    Nature 427:252-6. 2004
    ..The occurrence of protein splicing in vertebrates has important implications for the complexity of the vertebrate proteome and for the immune recognition of self and foreign peptides...
  46. ncbi Making sense of mass destruction: quantitating MHC class I antigen presentation
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0440, USA
    Nat Rev Immunol 3:952-61. 2003
  47. ncbi The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function
    James S Gibbs
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:7214-24. 2003
    ..These findings demonstrate that PB1-F2 possesses an MTS similar to other viral proteins and that this MTS, when fused to EGFP, is capable of independently compromising mitochondrial function and cellular viability...
  48. ncbi Monoclonal antibodies specific for discontinuous epitopes direct refolding of influenza A virus hemagglutinin
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892 03209, USA
    Mol Immunol 47:1132-6. 2010
    ....
  49. ncbi Viral interference with antigen presentation
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Nat Immunol 3:1019-25. 2002
    ....
  50. ncbi Designing CD8+ T cell vaccines: it's not rocket science (yet)
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Curr Opin Immunol 22:402-10. 2010
    ..With the rapid advances in this area of research, the dawn of rational vaccine design is at hand...
  51. ncbi Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain
    Suman R Das
    NIAID, Bethesda, MA, USA
    PLoS Pathog 6:e1001211. 2010
    ..This supports the conclusion that glycosylation generally shields HA from antibody-mediated neutralization, and implies that fitness costs in accommodating oligosaccharides limit virus escape via HA hyperglycosylation...
  52. ncbi Out with the old, in with the new? Comparing methods for measuring protein degradation
    Jonathan W Yewdell
    Cell Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, U S A
    Cell Biol Int 35:457-62. 2011
    ....
  53. ncbi Viral alteration of cellular translational machinery increases defective ribosomal products
    Peter Berglund
    Laboratory of Viral Diseases, NIAID, 4 Center Drive, NIH, Bethesda, MD 20892 0440, USA
    J Virol 81:7220-9. 2007
    ....
  54. ncbi Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 25:533-43. 2006
    ..Here, I review work that has extended immunodominance studies to viruses of greater complexity and to the real world of human antiviral immunity...
  55. ncbi The TL MHC class Ib molecule has only marginal effects on the activation, survival and trafficking of mouse small intestinal intraepithelial lymphocytes
    Nathalie Pardigon
    Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA
    Int Immunol 16:1305-13. 2004
    ....
  56. ncbi Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis
    Alexandre David
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33072. 2012
    ..We discuss possible translation independent functions for tRNA(Cys)...
  57. ncbi Innate immune and chemically triggered oxidative stress modifies translational fidelity
    Nir Netzer
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nature 462:522-6. 2009
    ..In demonstrating an unexpected conditional aspect of decoding mRNA, our findings illustrate the importance of considering alternative iterations of the genetic code...
  58. ncbi DRiPs solidify: progress in understanding endogenous MHC class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Trends Immunol 32:548-58. 2011
    ..DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity...
  59. ncbi New lane in the information highway: alternative reading frame peptides elicit T cells with potent antiretrovirus activity
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Exp Med 204:2501-4. 2007
    ..ARF-specific T cells control retroviral replication and select for viral escape in monkeys, providing the most compelling evidence to date for the biological relevance of ARF immunosurveillance...
  60. ncbi Plumbing the sources of endogenous MHC class I peptide ligands
    Jonathan W Yewdell
    Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0440, USA
    Curr Opin Immunol 19:79-86. 2007
    ....
  61. ncbi Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells
    Wanqiu Hou
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 119:3128-31. 2012
    ..These findings demonstrate that monocytes are uniquely susceptible to viral infection among blood mononuclear cells, with the likely purpose of generating cells with enhanced capacity to activate innate and acquired antiviral immunity...
  62. ncbi Caught in the act: intravital multiphoton microscopy of host-pathogen interactions
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Host Microbe 5:13-21. 2009
    ..Here we provide an overview of multiphoton microscopy with particular attention to its application for studying host-pathogen interactions...
  63. ncbi Immunoproteasomes: regulating the regulator
    Jonathan W Yewdell
    Cellular Biology Section, Laboratory of Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0440, USA
    Proc Natl Acad Sci U S A 102:9089-90. 2005
  64. ncbi Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo
    Shu-Bing Qian
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0440, USA
    J Biol Chem 277:38818-26. 2002
    ..The multifunctionality of X-Ub fusion proteins opens the possibility for a number of novel practical applications, including the imaging of Ub conjugate formation in living cells...
  65. ncbi MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines
    Surender Khurana
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Sci Transl Med 3:85ra48. 2011
    ..Thus, MF59 quantitatively and qualitatively enhances functional antibody responses to HA-based vaccines by improving both epitope breadth and binding affinity, demonstrating the added value of such adjuvants for influenza vaccines...
  66. ncbi Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells
    Sameh Basta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 168:5403-8. 2002
    ....
  67. ncbi HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation
    Carla Oseroff
    La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
    Proc Natl Acad Sci U S A 102:13980-5. 2005
    ..Finally, most epitopes were highly conserved among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting their potential use in vaccine and diagnostic applications...
  68. ncbi Inside the professionals
    Jonathan W Yewdell
    Nature 418:923-4. 2002
  69. ncbi HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products
    Valerie Pasquetto
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92109, USA
    J Immunol 175:5504-15. 2005
    ..These findings have implications for the design of new smallpox vaccines and the understanding of immune responses to large DNA viruses in general...
  70. ncbi Viruses in control of the immune system. Workshop on molecular mechanisms of immune modulation: lessons from viruses
    Antonio Alcami
    Department of Medicine, University of Cambridge, Addenbrooke's Hospital, UK
    EMBO Rep 3:927-32. 2002
  71. ncbi Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon
    Weisan Chen
    T Cell Laboratory, Cancer Vaccine Unit, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Australia
    Eur J Immunol 34:194-9. 2004
    ..Our findings support the relevance of cross-priming in CD8+ T cell responses to viruses and tumor cells, and demonstrate that cross-priming elicits CD8+ T cells to determinants generated by the endogenous processing pathway...
  72. ncbi Comparative immunopeptidomics of humans and their pathogens
    Sorin Istrail
    Celera Genomics, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:13268-72. 2004
    ....
  73. ncbi Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  74. ncbi T cells bite the hand that feeds them
    David C Tscharke
    Nat Med 9:647-8. 2003
  75. ncbi Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo
    Christopher C Norbury
    Present address: Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Nat Immunol 3:265-71. 2002
    ..These data provide direct evidence that virus-infected APCs prime naïve CD8+ T cells in vivo...
  76. ncbi Self-reporting peptides illuminate the MHC groove
    Jonathan W Yewdell
    Nat Chem Biol 3:201-2. 2007
  77. ncbi Cutting edge: MHC class I-Ly49 interaction regulates neuronal function
    Ofer Zohar
    Blanchette Rockefeller Neurosciences Institute, Johns Hopkins University Montgomery County Campus, Rockville, MD 20850, USA
    J Immunol 180:6447-51. 2008
    ..Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain...
  78. ncbi Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells
    Tonya J Roberts
    Department of Microbiology and Immunology, Indiana University School of Medicine and Walther Oncology Center, Indianapolis, IN 46202, USA
    J Immunol 168:5409-14. 2002
    ..These results suggest that the loading of a subset of glycolipid ligands onto CD1d1 molecules entails the delivery of cell surface CD1d1 molecules and an acidic environment in the endocytic pathway...
  79. ncbi The latest killer AP
    Margarita Del Val
    Nat Immunol 4:1049-50. 2003
  80. ncbi Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2
    Claudia Thilo
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden
    J Biol Chem 281:8950-7. 2006
    ..However, although the presence of Arg181 seems to be a prerequisite for US2 binding to HLA-A2, it is not sufficient for binding to all MHC class I alleles...
  81. ncbi Comment on "Large-scale sequence analysis of avian influenza isolates"
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
    Science 313:1573; author reply 1573. 2006
    ..However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene...
  82. ncbi Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination
    Weisan Chen
    T Cell Laboratory, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Immunol 173:5021-7. 2004
    ..We further show that immunodomination of PA(224-233)-specific TCD8+ by nucleoprotein 366-374-specific TCD8+ plays a critical role in the phenomena, and that this is unlikely to be mediated by TCD8+ lysis of APCs or other cells...