Research Topics
Genomes and Genes | Man Lung YeungSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individualsLaurent Houzet
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
Retrovirology 5:118. 2008..The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes...- Changes in microRNA expression profiles in HIV-1-transfected human cellsMan Lung Yeung
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
Retrovirology 2:81. 2005..We report distinct differences in miRNA profiles in mock-transfected HeLa cells versus HeLa cells transfected with an infectious HIV-1 molecular clone, pNL4-3... - RNA interference and HIV-1Man Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Adv Pharmacol 55:427-38. 2007 - Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybridMan Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
Nucleic Acids Res 37:6575-86. 2009..It was found to associate with the Ago2 protein, suggesting its possible function in the cellular RNAi machinery for targeting HIV-1... - A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replicationMan Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 284:19463-73. 2009..We discuss the similarities and differences between our shRNA findings for HIV-1 using a spreading infection assay in human Jurkat T-cells and results from other investigators who used siRNA-based screenings in HeLa or 293T cells... - Identification of small molecules that suppress microRNA function and reverse tumorigenesisKoichi Watashi
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:24707-16. 2010..These findings indicate that miRNA pathway-suppressing small molecules could potentially reverse tumorigenesis... - MicroRNAs in human immunodeficiency virus-1 infectionYamina Bennasser
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institue of Health, Bethesda, MD, USA
Methods Mol Biol 342:241-53. 2006..Finally, we use a scanning algorithm to search 3' untranslated regions (UTRs) of human messenger RNAs (mRNAs) in the attempt to predict potential sites targeted by HIV-1 miRNAs... - HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein, TRBPYamina Bennasser
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892-0460, USA
J Biol Chem 281:27674-8. 2006..Our data suggest that TAR RNA sequesters TRBP rendering it unavailable for downstream Dicer-RISC complexes. TAR-induced inhibition of Dicer-RISC activity in transfected cells was partially relieved by exogenous expression of TRBP... - Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1Man Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Cancer Res 68:8976-85. 2008..Collectively, the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells... - siRNA, miRNA and HIV: promises and challengesMan Lung Yeung
National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA
Cell Res 15:935-46. 2005..In this review, we discuss stratagems used by various viruses to avoid the cells' antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs)... - HIV-1 encoded candidate micro-RNAs and their cellular targetsYamina Bennasser
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Retrovirology 1:43. 2004..We propose that HIV has evolved to use vmiRNAs as a means to regulate cellular milieu for its benefit... - miRNAs in the biology of cancers and viral infectionsMan Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Curr Med Chem 14:191-7. 2007..Here, we will discuss examples of roles served by cellular miRNAs and virus-encoded miRNAs in the development of cancers and viral diseases... - Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions?Man Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
Retrovirology 4:74. 2007..Here, we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect, suppress, evade, modulate, or adapt to the host cell's ncRNA regulatory schema... - Human immunodeficiency virus type 1 replication and regulation of APOBEC3G by peptidyl prolyl isomerase Pin1Koichi Watashi
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 82:9928-36. 2008..Intriguingly, HIV-1 infection modulates the phosphorylation state of Pin1, enhancing its ability to moderate A3G activity. These new findings suggest a potential Vif-independent way for HIV-1 to moderate the cellular action of A3G... - Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate grooveBradley Sanville
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
PLoS Pathog 6:e1000974. 2010.... - Modulation of nuclear factor-kappaB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammationJean-Marie Peloponese
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA
Immunol Res 34:1-12. 2006..Here, we review current thinking on how Tax may affect both diseases through activation of NF-kappaB signaling... - Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor developmentMeritxell Gironella
Institut National de Santé et de Recherche Médicale, U624 Stress Cellulaire, F 13288 Marseille, France
Proc Natl Acad Sci U S A 104:16170-5. 2007..Finally, TP53INP1 expression is repressed by the oncogenic micro RNA miR-155, which is overexpressed in PDAC cells. TP53INP1 is a previously unknown miR-155 target presenting anti-tumoral activity...