Research Topics
| Zheng Xiong XiSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Mechanism-based medication development for the treatment of nicotine dependenceZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Acta Pharmacol Sin 30:723-39. 2009..For drugs in each category, we discuss the mechanistic rationale for their potential anti-nicotine efficacy, major findings in preclinical and clinical studies, and future research directions...- Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanismZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Neurochem 112:564-76. 2010..These findings suggest that 2-PMPA is effective in attenuating cocaine-induced reinstatement of drug-seeking behavior, likely by attenuating cocaine-induced increases in NAc DA and glutamate via pre-synaptic mGluR2/3s... - The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in ratsZheng Xiong Xi
Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:1393-405. 2006..Owing to these properties and to its lack of rewarding effects (as assessed by BSR and by substitution during drug self-administration), NGB 2904 merits further investigation as a potential agent for treatment of cocaine addiction... - Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbensZheng Xiong Xi
Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 26:8531-6. 2006.... - N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in ratsZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Neuropharmacology 58:304-13. 2010..These data suggest a potential utility for 2-PMPA or NAAG in the treatment of cocaine addiction... - Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in ratsZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neuropharmacology 53:771-82. 2007..Together, the present data, combined with previous findings, support the potential use of l-THP for treatment of cocaine addiction... - Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in ratsZheng Xiong Xi
Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 33:1735-45. 2008..Thus, AM 251 or other more potent CB1 receptor antagonists deserve further study as potentially effective anti-cocaine medications... - Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanismXia Li
Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Neuropsychopharmacology 34:1783-96. 2009.... - Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in ratsZheng Xiong Xi
Neuropsychopharmacology Section, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 176:57-65. 2004..We have previously shown that selective D3 receptor blockade by the novel D3 antagonist SB-277011A inhibits cocaine's reinforcing action and cocaine-induced reinstatement of cocaine-seeking behavior... - Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in ratsXiao Qing Peng
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States
Drug Alcohol Depend 97:207-15. 2008..This is in striking contrast to positive findings in the same animal models shown by another GABAmimetic--gamma-vinyl GABA (see companion piece to present article)... - The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in ratsXia Li
Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Neuropharmacology 54:542-51. 2008..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release... - Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in ratsXiao Qing Peng
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Eur J Pharmacol 627:156-61. 2010..These data suggest that orally effective NAAG peptidase inhibitors deserve further study as potential agents for the treatment of cocaine addiction... - Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in ratsXia Li
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
J Neurochem 114:1368-80. 2010..The present findings support the potential use of mGluR7 agonists for the treatment of cocaine addiction... - Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanismXiao Qing Peng
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, United States
Drug Alcohol Depend 97:216-25. 2008.... - PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in ratsAmanda E Higley
Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 USA
J Psychopharmacol 25:263-73. 2011.... - Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medicationsXiao Qing Peng
Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Neuropsychopharmacology 35:2564-78. 2010..Ideal agonist substitutes for cocaine should fully emulate methadone's actions, that is, functionally antagonizing cocaine's action while blocking monoamine transporters to augment synaptic DA... - The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in ratsKrista Spiller
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
Psychopharmacology (Berl) 196:533-42. 2008..We have previously reported that selective antagonism of brain D3 receptors by SB-277011A or NGB 2904 significantly attenuates cocaine- or nicotine-enhanced brain stimulation reward (BSR)... - Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in ratsKrista Spiller
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neuropharmacology 57:60-6. 2009.... - Brain cannabinoid CB? receptors modulate cocaine's actions in miceZheng Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA
Nat Neurosci 14:1160-6. 2011..These findings suggest that brain CB(2) receptors modulate cocaine's rewarding and locomotor-stimulating effects, likely by a dopamine-dependent mechanism... - Gamma-vinyl GABA increases nonvesicular release of GABA and glutamate in the nucleus accumbens in rats via action on anion channels and GABA transportersXiao Qing Peng
Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 208:511-9. 2010..We have recently reported that gamma-vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, elevates extracellular GABA but fails to alter dopamine release in the nucleus accumbens (NAc)... - Dopamine D(3) receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in ratsAmanda E Higley
National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, United States
Eur J Pharmacol 659:187-92. 2011.... - Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addictionZheng Xiong Xi
Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA
CNS Drug Rev 13:240-59. 2007..In addition, NGB 2904 may also act as a useful tool to study the role of D3 receptors in drug addiction... - Lower glutamate levels in rostral anterior cingulate of chronic cocaine users - A (1)H-MRS study using TE-averaged PRESS at 3 T with an optimized quantification strategyShaolin Yang
Neuroimaging Research Branch, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, MD 21224, USA
Psychiatry Res 174:171-6. 2009.... - Hypothesis-driven medication discovery for the treatment of psychostimulant addictionZheng Xiong Xi
National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Curr Drug Abuse Rev 1:303-27. 2008..We conclude that hypothesis-based medication development strategies could significantly promote medication discovery for the effective treatment of psychostimulant addiction... - The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in ratsXiao Qing Peng
National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Neuropharmacology 56:752-60. 2009.... - Agents in development for the management of cocaine abuseDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Drugs 64:1547-73. 2004..A recent phase I trial of a "cocaine vaccine" found it to be well tolerated and producing detectable levels of anti-cocaine antibodies for up to 9 months after immunisation... - Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbensZheng Xiong Xi
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC, USA
J Neurochem 87:1204-12. 2003..Together, these data indicate that group III mGluRs regulate in vivo extracellular glutamate in the nucleus accumbens by inhibiting non-vesicular glutamate release... - Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)Hanbing Lu
Neuroimaging Research Branch, National Institute on Drug Abuse NIDA, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 104:2489-94. 2007..These data suggest that MEMRI may serve as a tool for investigating the effects of pharmacological agents and opens an application of MRI to study CNS drug effects at a systems level... - Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic administration of GYKI 52466: a non-competitive AMPA receptor antagonistRatika Srivastava
National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
Neurosci Lett 508:106-9. 2012..We suggest that although AMPA receptors may be involved in cocaine reward and addiction, the AMPA receptor antagonist GYKI 52466 has low therapeutic potential for cocaine addiction treatment... - Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout miceXia Li
Neuropsychopharmacology Section, Chemical Biology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 204:1-11. 2009..Effect of cannabinoid CB1 receptor deletion on cocaine's actions is controversial. This is partly based on findings in CB1-receptor-knockout (CB1(-/-)) mice with CD1 genetic background...