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Species | Jeffery K TaubenbergerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Insights on influenza pathogenesis from the graveJeffery K Taubenberger
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Room 3E19A 2, MSC 3203, Bethesda, MD 20892 3203, USA
Virus Res 162:2-7. 2011..These studies have yielded much information about the origin and pathogenicity of the 1918 virus, but many questions still remain...- The pathology of influenza virus infectionsJeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Annu Rev Pathol 3:499-522. 2008.... - Pandemic influenza--including a risk assessment of H5N1J K Taubenberger
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Bethesda, MD 20892 3203, USA
Rev Sci Tech 28:187-202. 2009.... - Discovery and characterization of the 1918 pandemic influenza virus in historical contextJeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Antivir Ther 12:581-91. 2007.... - Influenza: the once and future pandemicJeffery K Taubenberger
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Dr, Rm 3E19A 2, MSC 3203, Bethesda, MD 20892 3203, USA
Public Health Rep 125:16-26. 2010..Influenza pandemics have been reported for at least 500 years, with inter-pandemic intervals averaging approximately 40 years... - An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and miceMatthew J Memoli
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
Virology 393:338-45. 2009.... - Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virusJohn C Kash
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Bethesda, MD 20892 3203, USA
Influenza Other Respi Viruses 4:121-7. 2010..Epidemiological evidence suggested that the current seasonal vaccine did not offer significant protection from the novel pandemic, and that people over the age of 50 were less susceptible to infection... - Examining the hemagglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR methodRuixue Wang
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Virology 375:182-9. 2008..This study further demonstrates the complex ecobiology of avian influenza A viruses in wild birds... - Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hostsMatthew J Memoli
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3203, USA
Clin Infect Dis 50:1252-5. 2010..We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir... - Phylogenetic analysis of low pathogenicity H5N1 and H7N3 influenza A virus isolates recovered from sentinel, free flying, wild mallards at one study site during 2006Vivien G Dugan
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
Virology 417:98-105. 2011..Both findings provide further insight into the natural history of AIVs in natural reservoirs... - Rapid selection of a transmissible multidrug-resistant influenza A/H3N2 virus in an immunocompromised hostMatthew J Memoli
Respiratory Virus Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MSC 3203 33 North Dr, Bethesda, MD 20892 3203, USA
J Infect Dis 201:1397-403. 2010..Antigenic drift and genetic variations during prolonged influenza infection have been demonstrated. In this report we describe a multidrug-resistant H3N2 influenza virus isolated from an immunocompromised patient after 5 days of therapy... - Role of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis for miceLi Qi
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208921, USA
J Virol 83:3754-61. 2009..Changing alpha2-3 to alpha2-6 binding specificity did not increase the lethality of an avian-adapted hemagglutinin. Thus, the 1918 hemagglutinin contains murine virulence determinants independent of receptor binding specificity... - Different evolutionary trajectories of European avian-like and classical swine H1N1 influenza A virusesEleca J Dunham
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3203, USA
J Virol 83:5485-94. 2009..Thus, in the context of emergence of an influenza A virus strain via a host switch event, it is difficult to predict what specific polygenic changes are needed for mammalian adaptation... - The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D bindingLi Qi
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Virology 412:426-34. 2011..In contrast, the virus expressing the HA of a seasonal influenza strain induced only mild disease with little lung pathology in infected mice and exhibited strong in vitro binding to SP-D... - Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infectionJudith D Easterbrook
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
Influenza Other Respi Viruses 5:198-205. 2011..Epidemiological and laboratory animal studies show that protection from severe 2009 pH1N1 infection is conferred by vaccination or prior infection with 1976 swH1N1 or 1918... - Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peakZong Mei Sheng
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:16416-21. 2011..These findings have important implications for understanding the origins and evolution of pandemic influenza viruses... - Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferretsMatthew J Memoli
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 203:348-57. 2011.... - Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swineDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Influenza Other Respi Viruses 4:327-37. 2010..To understand human influenza in a historical context of viral circulation in avian species, mammals, and in the environment... - The evolutionary genetics and emergence of avian influenza viruses in wild birdsVivien G Dugan
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Pathog 4:e1000076. 2008.... - Recent human influenza A/H3N2 virus evolution driven by novel selection factors in addition to antigenic driftMatthew J Memoli
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 200:1232-41. 2009.... - An avian outbreak associated with panzootic equine influenza in 1872: an early example of highly pathogenic avian influenza?David M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Influenza Other Respi Viruses 4:373-7. 2010..To our knowledge the scientific literature contains no mention of the nationwide 1872 poultry outbreak... - Influenza virus evolution, host adaptation, and pandemic formationJeffery K Taubenberger
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Cell Host Microbe 7:440-51. 2010..Here, we review the evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans, leading to pandemics and the establishment of seasonal viruses... - Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virusJudith D Easterbrook
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
Influenza Other Respi Viruses 5:418-25. 2011..Obesity has been identified as an independent risk factor for severe or fatal infection with 2009 pandemic H1N1 influenza (2009 pH1N1), but was not previously recognized for previous pandemic or seasonal influenza infections... - The 1918 influenza pandemic: lessons for 2009 and the futureDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Crit Care Med 38:e10-20. 2010..Thus, we must remain vigilant and use the knowledge we have gained from 1918 and other influenza pandemics to direct targeted research and pandemic influenza preparedness planning, emphasizing prevention, containment, and treatment... - Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparednessDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 198:962-70. 2008..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics... - Methods for molecular surveillance of influenzaRuixue Wang
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Expert Rev Anti Infect Ther 8:517-27. 2010.... - The role of radiology in influenza: novel H1N1 and lessons learned from the 1918 pandemicDaniel J Mollura
Radiology and Imaging Sciences, National Institutes of Health, Clinical Center, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Am Coll Radiol 7:690-7. 2010..The broad range of current imaging capabilities will make it possible to study influenza at the cellular level, in animal models, and in human clinical trials to elucidate the pathogenesis of severe illness and improve clinical outcomes... - Capturing a killer flu virusJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, MD, USA
Sci Am 292:48-57. 2005 - Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaquesDavid Safronetz
Laboratory of Virology, Hamilton, Montana, USA
J Virol 85:1214-23. 2011..Differences in virulence may explain more severe disease, as was seen with certain individuals infected with the emerged pandemic influenza virus. Thus, the nonhuman primate model closely mimics influenza in humans... - Effect of preservative on recoverable RT-PCR amplicon length from influenza A virus in bird fecesDavid L Evers
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Avian Dis 51:965-8. 2007..These results suggest that this approach is feasible in the field and that preserved specimens might be better assayed molecularly when preserved in guanidine or commercial buffers... - Detection of seasonal H3N2 influenza A virus by type-specific TaqMan minor groove binder probe assayRuixue Wang
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Diagn Microbiol Infect Dis 70:281-4. 2011..We describe a specific minor groove binder TaqMan assay for H3N2 viruses with a detection limit of 16.5 standard DNA copies... - The next influenza pandemic: can it be predicted?Jeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-2520, USA
JAMA 297:2025-7. 2007 - Fatal 1918 pneumonia case complicated by erythrocyte sicklingZong Mei Sheng
National Institutes of Health, Bethesda, Maryland, USA
Emerg Infect Dis 16:2000-1. 2010..The inheritance pattern of sickle cell anemia was determined in 1949; in 1957, Ingram identified the single amino acid change in hemoglobin S (4)... - Influenza and the origins of The Philips Collection, Washington, DCDavid M Morens
National Institutes of Health, Bethesda, MD, USA
Emerg Infect Dis 12:78-80. 2006 - Pandemic influenza's 500th anniversaryDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Clin Infect Dis 51:1442-4. 2010..It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches... - Pandemic and seasonal influenza: therapeutic challengesMatthew J Memoli
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Drug Discov Today 13:590-5. 2008.... - Ewing sarcoma family of tumors in unusual sites: confirmation by rt-PCRAtif A Ahmed
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Pediatr Dev Pathol 9:488-95. 2006..Accurate diagnosis of Ewing sarcoma family of tumors is crucial for the management of patients, and when found in such rare locations, diagnosis should be supported by immunohistochemical and/or molecular genetic studies... - Characterization of the 1918 "Spanish" influenza virus matrix gene segmentAnn H Reid
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
J Virol 76:10717-23. 2002.... - Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolutionElodie Ghedin
The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
Nature 437:1162-6. 2005..All data from this project are being deposited, without delay, in public archives... - The origin and virulence of the 1918 "Spanish" influenza virusJeffery K Taubenberger
Department of Molecular Pathology Armed Forces Institute of Pathology Rockville, Maryland, USA
Proc Am Philos Soc 150:86-112. 2006..This information should help elucidate how pandemic influenza virus strains emerge and what genetic features contribute to virulence in humans... - Heading off an influenza pandemicEdward C Holmes
Science 309:989. 2005 - Evidence of an absence: the genetic origins of the 1918 pandemic influenza virusAnn H Reid
Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Boulevard, Building 101, Rockville, Maryland 20850, USA
Nat Rev Microbiol 2:909-14. 2004..Determining whether a pandemic influenza virus can emerge by different mechanisms will affect the scope and focus of surveillance and prevention efforts... - 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variantsAnn H Reid
Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850-3125, USA
Emerg Infect Dis 9:1249-53. 2003 - 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birdsThomas G Fanning
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
J Virol 76:7860-2. 2002.... - The origin of the 1918 pandemic influenza virus: a continuing enigmaAnn H Reid
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Blvd, Building 101, Room 1057, Rockville, MD 20850-3125, USA
J Gen Virol 84:2285-92. 2003..Determining whether pandemic influenza virus strains can emerge via different pathways will affect the scope and focus of surveillance and prevention efforts... - Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virusTerrence M Tumpey
Southeast Poultry Research Laboratory, United States Department of Agriculture, Athens, GA 30605, USA
Proc Natl Acad Sci U S A 99:13849-54. 2002..These data suggest that current antiviral strategies would be effective in curbing the dangers of a re-emergent 1918 or 1918-like virus... - Characterization of the 1918 influenza virus polymerase genesJeffery K Taubenberger
Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
Nature 437:889-93. 2005..The sequence changes identified here may be important in the adaptation of influenza viruses to humans... - Characterization of the reconstructed 1918 Spanish influenza pandemic virusTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Science 310:77-80. 2005..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus... - Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in miceTerrence M Tumpey
Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
J Virol 79:14933-44. 2005.... - Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from SingaporeTeri J Franks
Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Wshington, DC 20306, USA
Hum Pathol 34:743-8. 2003..Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD... - The relationship between encephalitis lethargica and influenza: a critical analysisSherman McCall
Department of Clinical Pathology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
J Neurovirol 14:177-85. 2008..Almost 100 years after the EL epidemic, its etiology remains enigmatic, raising the possibility of a recurrence of EL in a future influenza pandemic... - SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissuesTracey Baas
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
J Interferon Cytokine Res 26:309-17. 2006.... - Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918Martha I Nelson
Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
PLoS Pathog 4:e1000012. 2008..Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized... - Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenzaGary K Geiss
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 99:10736-41. 2002.... - The genomic and epidemiological dynamics of human influenza A virusAndrew Rambaut
Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
Nature 453:615-9. 2008..These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions... - Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virusJohn C Kash
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Nature 443:578-81. 2006..Moreover, understanding the contribution of host immune responses to virulent influenza virus infections is an important starting point for the identification of prognostic indicators and the development of novel antiviral therapies... - Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditisPaul C McGovern
Division of Infectious Diseases, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
J Heart Lung Transplant 21:290-3. 2002..This case suggests those patients with fulminant viral myocarditis and refractory ventricular arrhythmias may be supported successfully with ventricular assist devices until myocardial recovery takes place... - Fixed and frozen flu: the 1918 influenza and lessons for the futureJeffery K Taubenberger
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, MD 20850-3125, USA
Avian Dis 47:789-91. 2003 - Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virusJames Stevens
Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 312:404-10. 2006.... - Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virusJames Stevens
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 303:1866-70. 2004.... - Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virusTerrence M Tumpey
Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Athens, GA 30605, USA
Proc Natl Acad Sci U S A 101:3166-71. 2004..These data suggest a strategy of vaccination that would be effective against a reemergent 1918 or 1918-like virus... - Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virusJohn C Kash
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
J Virol 78:9499-511. 2004..These studies document clear differences in gene expression profiles that were correlated with pulmonary disease pathology induced by virulent and attenuated influenza virus infections... - Influenza revisitedJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, Maryland, USA
Emerg Infect Dis 12:1-2. 2006 - Novel origin of the 1918 pandemic influenza virus nucleoprotein geneAnn H Reid
Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Blvd, Building 101, Rockville, MD 20850-3125, USA
J Virol 78:12462-70. 2004.... - 1918 Influenza: the mother of all pandemicsJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
Emerg Infect Dis 12:15-22. 2006..But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis... - Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificitiesJames Stevens
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Mol Biol 355:1143-55. 2006..The glycan array thus provides highly detailed profiles of influenza receptor specificity that can be used to map the evolution of new human pathogenic strains, such as the H5N1 avian influenza... - A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificityLaurel Glaser
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Virol 79:11533-6. 2005..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor...