Research Topics
Genomes and Genes | L M StaudtSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Genomic views of the immune system*L M Staudt
Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Annu Rev Immunol 18:829-59. 2000..The databases of gene expression emerging from these studies of normal immune responses will be used to interpret the pathological changes in gene expression that accompany autoimmunity, immune deficiencies, and cancers of immune cells...- Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridolL T Lam
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Genome Biol 2:RESEARCH0041. 2001..However, the mechanism of action of flavopiridol as an anti-cancer agent has not been fully elucidated... - Gene expression physiology and pathophysiology of the immune systemL M Staudt
Metabolism Branch, NCI, Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
Trends Immunol 22:35-40. 2001..Comprehensive databases of gene expression measurements can be used to understand the pathological mechanisms underlying disease processes... - BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania majorA L Dent
Metabolism Branch, National Cancer Institute, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD, USA
J Immunol 163:2098-103. 1999..These results show that STAT6 is required for susceptibility to L. major infection and suggest that IL-13 signaling through STAT6 may contribute to a nonhealing, exacerbated L. major infection... - BCL-6 expression during B-cell activationD Allman
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 87:5257-68. 1996..These observations suggest that the germinal center reaction provides unique activation signals to B cells that allow for continued, high-level BCL-6 expression... - Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6L M Staudt
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int Rev Immunol 18:381-403. 1999..The BCL-6 protein is a potent transcriptional repressor which presumably controls lymphocyte differentiation and induces lymphomas by regulating the expression of key downstream target genes... - Signatures of the immune responseA L Shaffer
Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N114, Bethesda, MD 20892, USA
Immunity 15:375-85. 2001..Finally, the transcriptional repression signature of BCL-6 reveals how this factor can prevent terminal differentiation of B cells and cause B cell lymphomas... - Control of inflammation, cytokine expression, and germinal center formation by BCL-6A L Dent
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Science 276:589-92. 1997..Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies... - T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6A L Dent
Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 95:13823-8. 1998..BCL-6, a transcriptional repressor that can bind to the same DNA binding motifs as STAT transcription factors, seems to regulate TH2 responses in vivo by a pathway independent of IL-4 and STAT6... - LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodiesA L Dent
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 88:1423-6. 1996..By double-immunogold labeling of PML and LYSP100, some LANDs were shown to contain both PML and LYSP100. Thus, PML is localized to a second subnuclear domain that is morphologically and biochemically distinct from PML NBs... - Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemiaA Rosenwald
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 194:1639-47. 2001..These genes were used to build a CLL subtype predictor that may help in the clinical classification of patients with this disease... - Molecular definition of the germinal centre stage of B-cell differentiationC Ma
Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
Philos Trans R Soc Lond B Biol Sci 356:83-9. 2001.... - Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cellsR E Davis
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1374, USA
J Exp Med 194:1861-74. 2001.... - Stromal gene signatures in large-B-cell lymphomasG Lenz
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 359:2313-23. 2008..Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear... - Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genesK P Wandinger
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1400, USA
Ann Neurol 50:349-57. 2001.... - A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryoM H Rosner
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892
Nature 345:686-92. 1990..The oct-3 gene is also expressed in primordial germ cells and in the female germ line... - Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytesP Scherle
Metabolism Branch, National Cancer Institute, Bethesda, MD 20892
Proc Natl Acad Sci U S A 90:7568-72. 1993.... - LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemiasC Ma
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 87:734-45. 1996..Therefore, the cloning of LAF-4 has defined a new family of potential regulatory proteins that may function in lymphoid development and oncogenesis... - Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulumT W Behrens
Metabolism Branch National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
J Immunol 153:682-90. 1994..These findings suggest that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins... - Gene regulation mediated by calcium signals in T lymphocytesS Feske
Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 2:316-24. 2001..We demonstrate an elaborate network of signaling pathways downstream of the T cell receptor, explaining the complexity of changes in gene expression during T cell activation... - Mapping of the mouse Bcl6 gene to chromosome 16X Liao
Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Mamm Genome 7:621-2. 1996 - Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigenS M Kang
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
Mol Cell Biol 12:3149-54. 1992..The relatively delayed kinetics of Oct-2 induction suggests that Oct-2 mediates the changes in gene expression which occur many hours or days following antigen stimulation of T lymphocytes... - Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulumT W Behrens
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Biol Chem 271:23528-34. 1996..In addition, the processing of the small lumenal domain of Jaw1 represents a novel post-translational protein modification performed by the endoplasmic reticulum... - Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolutionB Petryniak
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109
Proc Natl Acad Sci U S A 87:1099-103. 1990..Together, our data show that the POU-containing subfamily of homeobox genes have been highly conserved during vertebrate evolution, apparently as a result of selection for their DNA-binding and transcriptional regulatory properties... - Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphomaJ Iqbal
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Leukemia 21:2332-43. 2007..The biological role of BCL6 in translocated cases where repression of known target genes is not demonstrated is intriguing and warrants further investigation...