Karl B Scheidweiler

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Pharmacokinetics and pharmacodynamics of methylecgonidine, a crack cocaine pyrolyzate
    Karl B Scheidweiler
    University of Rochester School of Medicine, Rochester, NY, USA
    J Pharmacol Exp Ther 307:1179-87. 2003
  2. ncbi Excretion of Delta9-tetrahydrocannabinol in sweat
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Forensic Sci Int 174:173-7. 2008
  3. ncbi Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat
    Michael H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Dr, Suite 4500, Baltimore, MD 21224, USA
    Drug Metab Dispos 37:2163-70. 2009
  4. ncbi Validated gas chromatographic-negative ion chemical ionization mass spectrometric method for delta(9)-tetrahydrocannabinol in sweat patches
    Takeshi Saito
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 50:2083-90. 2004
  5. ncbi Development and validation of a solid-phase extraction gas chromatography-mass spectrometry method for the simultaneous quantification of methadone, heroin, cocaine and metabolites in sweat
    Bertrand R Brunet
    INSERM E 0324, Universite de Poitiers, Faculte de Medecine et Pharmacie, CHU de Poitiers, rue de la Miletrie, BP 577, 86021, Poitiers, France
    Anal Bioanal Chem 392:115-27. 2008
  6. ncbi Use of a novel abdominal wrap for protection of indwelling catheter exit sites in sheep
    Karl B Scheidweiler
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, New York 14642, USA
    Contemp Top Lab Anim Sci 41:24-6. 2002
  7. ncbi Simultaneous quantification of opiates, cocaine, and metabolites in hair by LC-APCI-MS/MS
    Karl B Scheidweiler
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Anal Chem 76:4358-63. 2004
  8. ncbi Dose-related distribution of codeine, cocaine, and metabolites into human hair following controlled oral codeine and subcutaneous cocaine administration
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 313:909-15. 2005
  9. ncbi Development and validation of a disk solid phase extraction and gas chromatography-mass spectrometry method for MDMA, MDA, HMMA, HMA, MDEA, methamphetamine and amphetamine in sweat
    Bruno S De Martinis
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Center of Legal Medicine, Ribeirao Preto, SP 14051 140, Brazil
    J Chromatogr B Analyt Technol Biomed Life Sci 852:450-8. 2007

Collaborators

Detail Information

Publications9

  1. ncbi Pharmacokinetics and pharmacodynamics of methylecgonidine, a crack cocaine pyrolyzate
    Karl B Scheidweiler
    University of Rochester School of Medicine, Rochester, NY, USA
    J Pharmacol Exp Ther 307:1179-87. 2003
    ..Intravenous pretreatment with atropine methyl bromide (15 microg/kg) antagonized methylecgonidine-induced hypotension in all three sheep, supporting the hypothesis that methylecgonidine acts as a muscarinic agonist in vivo...
  2. ncbi Excretion of Delta9-tetrahydrocannabinol in sweat
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Forensic Sci Int 174:173-7. 2008
    ..Oral ingestion of up to 14.8 mg THC daily does not produce a THC positive sweat patch test...
  3. ncbi Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat
    Michael H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Dr, Suite 4500, Baltimore, MD 21224, USA
    Drug Metab Dispos 37:2163-70. 2009
    ..Finally, given key similarities between MDMA pharmacokinetics in rats and humans, data from rats may be clinically relevant when appropriate dosing conditions are used...
  4. ncbi Validated gas chromatographic-negative ion chemical ionization mass spectrometric method for delta(9)-tetrahydrocannabinol in sweat patches
    Takeshi Saito
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 50:2083-90. 2004
    ....
  5. ncbi Development and validation of a solid-phase extraction gas chromatography-mass spectrometry method for the simultaneous quantification of methadone, heroin, cocaine and metabolites in sweat
    Bertrand R Brunet
    INSERM E 0324, Universite de Poitiers, Faculte de Medecine et Pharmacie, CHU de Poitiers, rue de la Miletrie, BP 577, 86021, Poitiers, France
    Anal Bioanal Chem 392:115-27. 2008
    ..9% of target. Heroin hydrolysis during specimen processing was <11%. This novel assay offers effective monitoring of drug exposure during drug treatment, workplace and criminal justice monitoring programs...
  6. ncbi Use of a novel abdominal wrap for protection of indwelling catheter exit sites in sheep
    Karl B Scheidweiler
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, New York 14642, USA
    Contemp Top Lab Anim Sci 41:24-6. 2002
    ..These wraps provided protection of the catheters and exit sites, with no chewed catheters or visible signs of exit-site inflammation or infection for up to 22 weeks postoperatively...
  7. ncbi Simultaneous quantification of opiates, cocaine, and metabolites in hair by LC-APCI-MS/MS
    Karl B Scheidweiler
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Anal Chem 76:4358-63. 2004
    ..0% for all analytes. Methanolic sonication produced less than 5% hydrolysis of cocaine and 6-acetylmorphine. The method should be useful for studying cocaine and opiate distribution into hair...
  8. ncbi Dose-related distribution of codeine, cocaine, and metabolites into human hair following controlled oral codeine and subcutaneous cocaine administration
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 313:909-15. 2005
    ..These data are the first demonstrating melanin-related incorporation of cocaine and metabolites into human hair following controlled cocaine administration...
  9. ncbi Development and validation of a disk solid phase extraction and gas chromatography-mass spectrometry method for MDMA, MDA, HMMA, HMA, MDEA, methamphetamine and amphetamine in sweat
    Bruno S De Martinis
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Center of Legal Medicine, Ribeirao Preto, SP 14051 140, Brazil
    J Chromatogr B Analyt Technol Biomed Life Sci 852:450-8. 2007
    ..5 ng/patch, and 5 ng/patch for MDA, HMA and HMMA. This fully validated procedure was more sensitive than previously published analytical methods and permitted the simultaneous analysis of multiple amphetamine analogs in human sweat...