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Genomes and Genes | Juan M SaavedraSummaryAffiliation: National Institutes of Health Country: USA Publications
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Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implicationsJuan M Saavedra
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room 2D 57, Bethesda, MD 20892, USA
Psychoneuroendocrinology 36:1-18. 2011..Blockade of AT(1) receptors offers a novel and safe therapeutic approach for the treatment of illnesses of increasing prevalence and socioeconomic impact, such as mood disorders and neurodegenerative diseases of the brain...- Angiotensin II: multitasking in the brainJuan M Saavedra
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Hypertens Suppl 24:S131-7. 2006..Additional preclinical studies and controlled clinical trials are necessary to confirm the efficacy of this novel therapeutic approach... - A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine bindingJuan M Saavedra
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Neuropsychopharmacology 31:1123-34. 2006..We propose that AT1 receptor antagonists can be considered as compounds with possible therapeutic anti-stress and anti-anxiety properties... - Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonistsJuan M Saavedra
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1514, USA
Regul Pept 128:227-38. 2005..Blockade of brain angiotensin II AT(1) receptors offers a novel therapeutic opportunity for the treatment of anxiety and other stress-related disorders... - Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the BrainJuan M Saavedra
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Cell Mol Neurobiol 26:1099-111. 2006..8. These results strongly suggest that inhibition of AT(1) receptors should be considered as a preventive therapeutic measure to protect the brain from ischemia, and as a possible novel therapy of inflammatory conditions of the brain... - Brain and peripheral angiotensin II play a major role in stressJuan M Saavedra
Section on Pharmacology, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Stress 10:185-93. 2007..Our observations demonstrate that Ang II is an important stress hormone, and that blockade of AT(1) receptors could be proposed as a potentially useful therapy for stress-induced disorders... - The discovery of a novel macrophage binding siteJuan M Saavedra
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
Cell Mol Neurobiol 26:509-26. 2006..10. Our observations indicate that CGP42112 or related molecules could be considered of interest as potential anti-inflammatory compounds... - Brain angiotensin II: new developments, unanswered questions and therapeutic opportunitiesJuan M Saavedra
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Room 2D 57, Bethesda, Maryland 20892, USA
Cell Mol Neurobiol 25:485-512. 2005.... - Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injuryClaudia Bregonzio
Section on Pharmacology, National Institute of Mental Health, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Physiol Gastrointest Liver Physiol 285:G414-23. 2003..Angiotensin II has a crucial role, through stimulation of AT1 receptors, in the production and progression of stress-induced gastric injury, and AT1 receptor antagonists could be of therapeutic benefit... - In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary glandEnrique Sanchez-Lemus
Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Brain Behav Immun 23:945-57. 2009..There is a complementary and complex influence of the PVN and circulating cytokines on the initial pituitary response to LPS. Our findings support the proposal that ARBs may be considered for the treatment of inflammatory conditions... - Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleenEnrique Sanchez-Lemus
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Physiol Regul Integr Comp Physiol 296:R1376-84. 2009..We postulate that ARBs may have therapeutic effects on inflammatory conditions... - AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive ratsJin Zhou
Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Stroke 37:1271-6. 2006..In this study, we tried to clarify the presence and regulation of the local renin-angiotensin system (RAS) in brain microvessels in hypertension... - Angiotensin II AT1 receptor blockade decreases lipopolysaccharide-induced inflammation in the rat adrenal glandEnrique Sanchez-Lemus
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, MSC 1514, Building, 10, Room 2D57, Bethesda, Maryland 20892, USA
Endocrinology 149:5177-88. 2008..We postulate that the ARBs may have therapeutic effects on inflammatory conditions... - Peripherally administered angiotensin II AT1 receptor antagonists are anti-stress compounds in vivoJaroslav Pavel
Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 1148:360-6. 2008..Our results demonstrate that Angiotensin II, through AT(1) receptor stimulation, is a major stress hormone, and that ARBs, in addition to their antihypertensive effects, may be considered for the treatment of stress-related disorders... - Oral administration of an AT1 receptor antagonist prevents the central effects of angiotensin II in spontaneously hypertensive ratsAlicia Seltzer
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm 2D57, 10 Center Dr, MSC-1514, Bethesda, MD 20892, USA
Brain Res 1028:9-18. 2004.... - A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTHMiroslava Macova
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Brain Res 1250:130-40. 2009..Blockade of brain AT(2) receptors is compatible with enhanced hypothalamic-pituitary-adrenal axis and decreased central sympathetic system activity... - Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive ratsHiromichi Ando
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Stroke 35:1726-31. 2004..CONCLUSIONS: The antiinflammatory effects of AT1 receptor antagonists may be an important mechanism in protecting against ischemia... - Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strainHiromichi Ando
Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg. 10, Room 2D-57, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1018:345-50. 2004..The anti-inflammatory effects of AT(1) receptor antagonists may be an important mechanism for protection against ischemia and could participate in the anti-stress properties of this class of compounds... - Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcriptionMiroslava Jezova
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 144:2092-101. 2003..Whereas AT(1) and AT(2) receptors involve the Fos-related antigen Fra-2, AT(1) receptor transcriptional effects include pCREB and ERK2, indicating common as well as different regulatory mechanisms for each receptor type... - Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the ratGustavo Baiardi
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, MSC 1514, Building 10, Room 2D 57, Bethesda, MD 20892, USA
Regul Pept 124:7-17. 2005..Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney... - Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized ratsMiroslava Macova
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Neuroendocrinology 88:276-86. 2008..The AT2 receptor upregulation and the decrease in AT1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy... - Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stressInes Armando
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Brain Res 1142:92-9. 2007..Inhibition of central AT(1) receptors limits the CRF response to stress and should be considered as a therapeutic tool to preserve homeostasis under chronic stress conditions... - Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive ratsJin Zhou
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Cereb Blood Flow Metab 25:878-86. 2005..These compounds might be considered as potential therapeutic agents against ischemic and inflammatory diseases of the brain... - Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stressOlga A Tjurmina
Laboratory of Clinical Science, NIMH, NIH, Bldg 10, Rm 3D41, 10 Center Dr, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1018:99-104. 2004..Our results indicate that SERT function not only restrains stress-induced EPI release but also is required for the increase in adrenal catecholamine synthesis and AT(2) receptor expression... - Increased angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted miceJaroslav Pavel
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Dr MSC 1514 Bethesda, Maryland 20892, USA
Regul Pept 158:156-66. 2009..AT(1) upregulation explains the increased sensitivity to Angiotensin II characteristic of the AT(2)(-/-) phenotype, consistent with enhanced AT(1) receptor activation in a number of tissues... - Decreased hypothalamic and adrenal angiotensin II receptor expression and adrenomedullary catecholamines in transgenic mice with impaired glucocorticoid receptor functionPaul Jain
Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuroendocrinology 80:171-80. 2004..Decreased hypothalamic and adrenal Ang II receptor stimulation as a result of decreased GR expression may explain the decreased hypothalamic CRH and AVP and decreased adrenomedullary and sympathetic activities in this model... - Candesartan reduces the innate immune response to lipopolysaccharide in human monocytesIgnacio M Larrayoz
Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
J Hypertens 27:2365-76. 2009..We asked whether AT1 receptor inhibition would reduce the innate inflammatory response induced by bacterial lipopolysaccharide (LPS)... - Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibitionHaruki Yamakawa
Section on Pharmacology, Division of Intramural Health Programs, National Institute of Mental Health NIH DHHS, 10 Center Drive, Building 10, Room 2D 57 Bethesda, MD 20892, USA
J Cereb Blood Flow Metab 23:371-80. 2003.... - Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-? activation in human monocytesTao Pang
Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Hypertens 30:87-96. 2012.... - Estrogen upregulates renal angiotensin II AT(2) receptorsInes Armando
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Physiol Renal Physiol 283:F934-43. 2002..We propose that the protective effects of estrogen may be partially mediated through enhancement of AT(2) receptor stimulation... - Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive ratsHaruki Yamakawa
Section on Pharmacology, IRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D-57, Bethesda, MD 20892, USA
Regul Pept 111:117-22. 2003.... - Angiotensin II AT1 receptor blockade prolongs the lifespan of spontaneously hypertensive rats and reduces stress-induced release of catecholamines, glucocorticoids, and vasopressinGustavo Baiardi
Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D 57, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1018:131-6. 2004..The long-term protective effects of AT(1) receptor blockade can be important in animals vulnerable to stress and, in conjunction with the normalization of blood pressure, can prolong lifespan through end-organ protection... - Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the ratJaroslav Pavel
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
Brain Res 1246:111-22. 2008..We found inconsistent levels of AT(2) receptor binding and mRNA. Our results suggest multiple roles of Angiotensin II AT(1) receptors in the regulation of sensory and motor functions... - Anti-inflammatory effects of angiotensin receptor blockers in the brain and the peripheryJulius Benicky
Department of Health and Human Services, Division of Intramural Research Programs, Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Cell Mol Neurobiol 29:781-92. 2009..ARBs, due to their immune response-limiting properties, may be considered as therapeutically useful in a number of inflammatory diseases of the peripheral organs and the brain... - Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonistTakeshi Ito
Section on Pharmacology, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Stroke 33:2297-303. 2002.... - Angiotensin II AT(1) receptor blockade ameliorates brain inflammationJulius Benicky
Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 36:857-70. 2011..Our results indicate that these compounds may offer a novel and safe therapeutic approach for the treatment of brain disorders... - Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilatorAlfredo Martinez
Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Biochem J 383:413-8. 2004..The present study defines a new mechanism through which MMP-2 may regulate blood pressure by simultaneously eliminating a vasodilator and generating a vasoconstrictor... - Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter geneOlga A Tjurmina
Laboratory of Clinical Science, National Institute of Mental Health, and Clinical Neurocardiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 143:4520-6. 2002..Exaggerated adrenomedullary responses seem to be an autonomic correlate of the anxiety-like behaviors in 5-HTT knockout mice... - Increased angiotensin II AT(1) receptor expression in paraventricular nucleus and hypothalamic-pituitary-adrenal axis stimulation in AT(2) receptor gene disrupted miceInes Armando
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuroendocrinology 76:137-47. 2002..Our results provide an explanation for the increased sensitivity to stress in this model... - Stress and angiotensin II: novel therapeutic opportunitiesInes Armando
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1514, USA
Curr Drug Targets CNS Neurol Disord 2:413-9. 2003..A novel role emerges for the use of peripheral and centrally acting AT1 receptor antagonists as therapeutically advantageous for the treatment of stress-related disorders... - Molecular cloning, characterization, and distribution of the gerbil angiotensin II AT2 receptorKwang Lae Hoe
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1514, USA
Am J Physiol Regul Integr Comp Physiol 285:R1373-83. 2003.... - Site-directed mutagenesis of the gerbil and human angiotensin II AT(1) receptors identifies amino acid residues attributable to the binding affinity for the nonpeptidic antagonist losartanKwang-Lae Hoe
Section on Pharmacology, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Mol Pharmacol 61:1404-15. 2002..The study of gerbil natural mutants allowed us to advance our understanding of amino acids selectively involved in the determination of antagonist affinity for gerbil and, most importantly, for human angiotensin II AT(1) receptors... - Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disordersWolfgang H Sommer
Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1108, USA
J Mol Med (Berl) 86:723-8. 2008.... - Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgammaStefan Zorad
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
Eur J Pharmacol 552:112-22. 2006..The decrease in the pro-inflammatory cytokine TNFalpha and the increase in the anti-inflammatory adipokine adiponectin indicate that Candesartan cilexetil may exert significant anti-inflammatory properties... - Increased expression of cardiac angiotensin II type 1 (AT(1)) receptors decreases myocardial microvessel density after experimental myocardial infarctionRudolf A de Boer
Thoraxcenter, Department of Cardiology, Hanzeplein 1, 9713 GZ, PO Box 30.001, 9700 RB, University Hospital, Groningen, The Netherlands
Cardiovasc Res 57:434-42. 2003..This suggests that efficacy of AT(1) receptor blockers post-MI may not only be due to attenuation of LV remodeling, but also to a stimulatory effect on angiogenesis... - Studies on genes and hypertension: a daunting taskJuan M Saavedra
J Hypertens 23:929-32. 2005 - The challenge of genetic studies in hypertensionJuan M Saavedra
Circ Res 100:1389-93. 2007