Elena M Pugacheva

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Cloning and characterization of zebrafish CTCF: Developmental expression patterns, regulation of the promoter region, and evolutionary aspects of gene organization
    Elena M Pugacheva
    Molecular Pathology Section, Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Gene 375:26-36. 2006
  2. ncbi The structural complexity of the human BORIS gene in gametogenesis and cancer
    Elena M Pugacheva
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 5:e13872. 2010
  3. ncbi Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors
    Stéphanie Renaud
    Section of Molecular Pathology, Laboratory of Immunopathology, NIAID, NIH, Rockville, MD 20815, USA
    Nucleic Acids Res 35:7372-88. 2007
  4. ncbi Transcription factor BORIS (Brother of the Regulator of Imprinted Sites) directly induces expression of a cancer-testis antigen, TSP50, through regulated binding of BORIS to the promoter
    Natsuki Kosaka-Suzuki
    Laboratory of Immunopathology, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 286:27378-88. 2011
  5. ncbi Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation
    Elena M Pugacheva
    Molecular Pathology Section, Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook I Rm 1417, Rockville, MD 20852, USA
    Hum Mol Genet 14:953-65. 2005
  6. ncbi Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity
    Galina N Filippova
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 62:48-52. 2002
  7. ncbi Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1
    Galina V Fitzpatrick
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cell Biol 27:2636-47. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Cloning and characterization of zebrafish CTCF: Developmental expression patterns, regulation of the promoter region, and evolutionary aspects of gene organization
    Elena M Pugacheva
    Molecular Pathology Section, Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Gene 375:26-36. 2006
    ..Transfection assays with luciferase reporter-constructs identified a core promoter region within 146 bp immediately upstream of the transcriptional start site of zebrafish CTCF that is located at a highly conserved YY1/Initiator element...
  2. ncbi The structural complexity of the human BORIS gene in gametogenesis and cancer
    Elena M Pugacheva
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 5:e13872. 2010
    ..While recent studies demonstrated that BORIS is a transcriptional activator of testis-specific genes, little is generally known about its biological and molecular functions...
  3. ncbi Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors
    Stéphanie Renaud
    Section of Molecular Pathology, Laboratory of Immunopathology, NIAID, NIH, Rockville, MD 20815, USA
    Nucleic Acids Res 35:7372-88. 2007
    ..These results provide a mechanistic basis for understanding cancer-related associations between haploinsufficiency of CTCF and BORIS derepression, and between the lack of functional p53 and aberrant activation of BORIS...
  4. ncbi Transcription factor BORIS (Brother of the Regulator of Imprinted Sites) directly induces expression of a cancer-testis antigen, TSP50, through regulated binding of BORIS to the promoter
    Natsuki Kosaka-Suzuki
    Laboratory of Immunopathology, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 286:27378-88. 2011
    ..To our knowledge this is the first report of regulated expression of one CTA by another to be validated in a physiological context...
  5. ncbi Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation
    Elena M Pugacheva
    Molecular Pathology Section, Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook I Rm 1417, Rockville, MD 20852, USA
    Hum Mol Genet 14:953-65. 2005
    ..These observations are in keeping with the possibility that the choice of X chromosome inactivation reflects stabilization of a higher order chromatin conformation impinging on the CTCF-XIST promoter complex...
  6. ncbi Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity
    Galina N Filippova
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 62:48-52. 2002
    ..These observations suggest that CTCF may represent a novel tumor suppressor gene that displays tumor-specific "change of function" rather than complete "loss of function."..
  7. ncbi Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1
    Galina V Fitzpatrick
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cell Biol 27:2636-47. 2007
    ..These results suggest that the KvDMR1 ICR consists of multiple, independent cis-acting modules. Dissection of KvDMR1 into its functional components should help elucidate the mechanism of its function in vivo...