Research Topics
| P PacherSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Interplay of cannabinoid 2 (CB(2)) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegenerationPal Pacher
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
J Mol Med (Berl) 90:347-51. 2012....- Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathyMohanraj Rajesh
Corresponding author Pál Pacher
Diabetes 61:716-27. 2012..Conversely, CB(1) receptor inhibition may be beneficial in the treatment of diabetic cardiovascular complications... - Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in miceJoelle Rolli
Department of Intensive Care Medicine, University Hospital Medical Center and Faculty of Biology and Medicine, Rue du Bugnon 46, Lausanne 1010, Switzerland
Crit Care 14:R160. 2010..Therefore, we determined TLR5 expression and the ability of flagellin to trigger prototypical innate immune responses and apoptosis in major organs from mice... - Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitorsPal Pacher
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health, NIAAA, Bethesda MD 20892 9413, USA
Cardiovasc Drug Rev 25:235-60. 2007.... - Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioningP Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 9413, USA
Br J Pharmacol 153:252-62. 2008.... - The emerging role of the endocannabinoid system in cardiovascular diseasePal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Semin Immunopathol 31:63-77. 2009.... - Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: implications for inflammatory liver diseasesPal Pacher
Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, Maryland 20892 9413, USA
Am J Physiol Gastrointest Liver Physiol 294:G850-4. 2008..which play pivotal role in the early development and progression of inflammatory and other liver diseases... - Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human diseasePal Pacher
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Pathol 173:2-13. 2008.... - Measurement of cardiac function using pressure-volume conductance catheter technique in mice and ratsPal Pacher
Section on Oxidative Stress Tissue Injury, Laboratories of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, Maryland 20892 9413, USA
Nat Protoc 3:1422-34. 2008..The completion of the protocol takes 1-4 h (depending on the experimental design/end points)... - Is lipid signaling through cannabinoid 2 receptors part of a protective system?P Pacher
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
Prog Lipid Res 50:193-211. 2011.... - Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraepiPal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health/NIAAA, 5625 Fishers Lane, Room 2-N17, MSC 9413, Bethesda, MD 20892-9413, USA
Free Radic Biol Med 44:969-71. 2008 - Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolasePal Pacher
National Institutes of Health, NIAAA, Laboratory of Physiological Studies, 5625 Fishers Lane MSC 9413, Rm 2S24, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 289:H533-41. 2005.... - Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying themePal Pacher
National Institutes of Health, NIAAA, Laboratory of Physiologic Studies, Bethesda, MD 20892, USA
Antioxid Redox Signal 7:1568-80. 2005..This review focuses on the role of PARP in diabetic complications and the unique therapeutic potential of PARP inhibition in the prevention or reversal of diabetic complications... - Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out micePal Pacher
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
J Physiol 558:647-57. 2004..The role of TRPV(1) receptors is limited to the transient activation of the Bezold-Jarisch reflex by very high initial plasma concentrations of anandamide... - Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinolPal Pacher
Laboratory of Physiological Studies, National Institute on Alcohol Aabuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2N 17, Bethesda, Maryland 20892 9413, USA
Pharmacol Rev 58:87-114. 2006..Here we present a critical overview of the effects of XO inhibitors in various pathophysiological conditions and also review the various emerging therapeutic strategies offered by this approach... - Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failurePal Pacher
National Institute on Alcohol Abuse and Alcoholism, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892 8115, USA
Am J Physiol Heart Circ Physiol 287:H2132-7. 2004..P-V analysis is a sensitive method to determine cardiac function in rats... - A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced agingPal Pacher
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park Bldg Rm 445, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892 8115, USA
J Pharmacol Exp Ther 311:485-91. 2004..Thus, pharmacological inhibition of PARP may represent a novel approach to improve cardiac and vascular dysfunction associated with aging... - Nitric oxide and peroxynitrite in health and diseasePal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Physiol Rev 87:315-424. 2007..Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review... - Blood pressure regulation by endocannabinoids and their receptorsPal Pacher
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
Neuropharmacology 48:1130-8. 2005.... - Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetesPal Pacher
National Institutes of Health, NIAAA, Laboratory of Physiologic Studies, 5625 Fishers Lane MSC 9413, Bethesda, Maryland 20852, USA
Curr Opin Pharmacol 6:136-41. 2006.... - CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytesPartha Mukhopadhyay
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, NIH NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Cardiovasc Res 85:773-84. 2010.... - Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitroPartha Mukhopadhyay
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 296:H1466-83. 2009..Thus, peroxynitrite is a major trigger of DOX-induced cell death both in vivo and in vivo, and the modulation of the pathways leading to its generation or its effective neutralization can be of significant therapeutic benefit... - Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injurySandor Batkai
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
FASEB J 21:1788-800. 2007..We also demonstrate that CB2-/- mice have a normal hemodynamic profile... - Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosisMohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
J Leukoc Biol 82:1382-9. 2007..These findings suggest that selective CB(2) receptor agonists may represent a novel, protective strategy against I/R injury by attenuating oxidative stress, inflammatory response, and apoptosis... - CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy modelPartha Mukhopadhyay
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
Br J Pharmacol 160:657-68. 2010.... - Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicityPartha Mukhopadhyay
Laboratory of Physiological Studies, NIH NIAAA, Bethesda, Maryland 20892, USA
J Am Coll Cardiol 50:528-36. 2007..We aimed to explore the effects of pharmacologic inhibition of cannabinoid-1 (CB1) receptor in in vivo and in vitro models of doxorubicin (DOX)-induced cardiotoxicity... - Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolaseSandor Batkai
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health NIAAA, 5625 Fishers Ln, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H909-18. 2007..These findings suggest that pharmacological inhibition of FAAH may represent a novel protective strategy against chronic inflammation, oxidative/nitrative stress, and apoptosis associated with cardiovascular aging and atherosclerosis... - The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channelsGrzegorz Godlewski
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892 9413, USA
J Pharmacol Exp Ther 328:351-61. 2009..3) Direct BK(Ca) channel activation probably contributes to the endothelium-independent component of ARA-S-induced mesenteric vasorelaxation. 4) O-1918 is a BK(Ca) channel inhibitor... - Nitrosative stress and pharmacological modulation of heart failurePal Pacher
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2S24, Bethesda, MD 20892 9413, USA
Trends Pharmacol Sci 26:302-10. 2005.... - Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic ratsSandor Batkai
Section on Neuroendocrinology, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, MSC 9413, Rm 2N17, 5625 Fishers Lane, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H1689-95. 2007.... - Endocannabinoids and cardiac contractile function: pathophysiological implicationsSandor Batkai
Phenotyping Core, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Pharmacol Res 60:99-106. 2009..In this review we will discuss recent advances in understanding the role of CB1 receptors and endocannabinoids in the regulation of cardiac function in cirrhotic cardiomyopathy and in doxorubicin-induced heart failure... - MicroRNA signatures of resveratrol in the ischemic heartPartha Mukhopadhyay
Laboratory of Physiologic Studies, NIAAA, National Institute of Health, Bethesda, Maryland, USA
Ann N Y Acad Sci 1215:109-16. 2011..For example, a unique miRNA footprint is present in the heart treated with resveratrol. Targets of those miRNAs have potential implications for physiological and pathophysiological processes in health and disease... - Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cellsMohanraj Rajesh
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
Br J Pharmacol 160:688-700. 2010.... - Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathyMohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, Bethesda, MD 20852, USA
J Cell Mol Med 13:2330-41. 2009.... - Simple quantitative detection of mitochondrial superoxide production in live cellsPartha Mukhopadhyay
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, Bethesda, MD 20892 9413, USA
Biochem Biophys Res Commun 358:203-8. 2007..This method can also be adapted for immune cell studies with mixed population of T or B cells or their subsets to analyze mitochondrial superoxide levels using multiple labeled surface markers in individual populations... - Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout miceNorio Horiguchi
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Hepatology 51:1724-34. 2010.... - CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesionMohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H2210-8. 2007.... - Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusionKwan Hoon Moon
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 2092 9410, USA
Gastroenterology 135:1344-57. 2008..We also studied the effects of a superoxide dismutase mimetic/peroxynitrite scavenger metalloporphyrin (MnTMPyP) on oxidatively modified proteins and their functions... - Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residuesD B Fegley
National Institute of Mental Health National Institutes of Health, Bethesda, MD, USA
Genes Brain Behav 7:933-42. 2008..Current data support the hypothesis that TIP39 modulates anxiety-related behaviors following environmental provocation... - Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferationMohanraj Rajesh
Laboratory of Physiological Studies, NIAAA, National Institutes of Health, Section on Oxidative Stress and Tissue Injury, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Biochem Biophys Res Commun 377:1248-52. 2008.... - Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathyPartha Mukhopadhyay
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 48:457-67. 2010.... - Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?Pal Pacher
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Laboratory Physiologic Studies, Bethesda, MD 20892 8115, USA
Curr Pharm Des 10:2463-75. 2004..The primary goal of this review is to shed light on the recently observed clinically important cardiovascular effects of new antidepressants and antipsychotics and discuss the mechanism beyond this phenomenon... - Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injuryAndrew M Miller
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Alcohol Clin Exp Res 34:719-25. 2010..We have previously shown that IL-6 also activates STAT3 in sinusoidal endothelial cells (SECs). Thus, the purpose of this study was to investigate whether STAT3 in endothelial cells also plays a protective role in alcoholic liver injury... - Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injuryNorio Horiguchi
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
Gastroenterology 134:1148-58. 2008..Signal transducer and activator of transcription 3 (STAT3) is known to be activated in human alcoholic liver disease, but its role in the pathogenesis of alcoholic liver injury remains obscure... - Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopyPartha Mukhopadhyay
Section on Oxidative Stress Tissue Injury, Laboratories of Physiological Studies, National Institutes of Health NIAAA, Bethesda, Maryland 20892, USA
Nat Protoc 2:2295-301. 2007..This method combined with fluorescent microscopy may be very useful to reveal important spatial-temporal changes in mitochondrial superoxide production and execution of programmed cell death in virtually any cell type... - Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruptionMohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H610-9. 2007.... - Trends in the development of new antidepressants. Is there a light at the end of the tunnel?Pal Pacher
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Laboratory of Physiologic Studies, Rockville, MD 20852, USA
Curr Med Chem 11:925-43. 2004..The goal of this review is to give a brief overview of the major advances from monoamine-based treatment strategies, and particularly focus on the new emerging approaches in the treatment of depression...