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| Retha R NewboldSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Developmental exposure to endocrine-disrupting chemicals programs for reproductive tract alterations and obesity later in lifeRetha R Newbold
Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
Am J Clin Nutr 94:1939S-1942S. 2011....- Uterine adenocarcinoma in mice treated neonatally with genisteinR R Newbold
Developmental Endocrinology Section, Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Cancer Res 61:4325-8. 2001..Thus, the use of soy-based infant formulas in the absence of medical necessity and the marketing of soy products designed to appeal to children should be closely examined... - Lessons learned from perinatal exposure to diethylstilbestrolRetha R Newbold
Developmental Endocrinology Section, Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 199:142-50. 2004.... - Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effectsRetha R Newbold
Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Reprod Toxicol 18:399-406. 2004.... - Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generationsRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Mail Drop E4 02, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Endocrinology 147:S11-7. 2006.... - Developmental exposure to endocrine disruptors and the obesity epidemicRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Mail Drop E4 02, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
Reprod Toxicol 23:290-6. 2007..This experimental animal model provides an example of the growing scientific field termed "the developmental origins of adult disease" and suggests new targets of abnormal programming by endocrine disrupting chemicals... - Cell response endpoints enhance sensitivity of the immature mouse uterotropic assayR R Newbold
Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
Reprod Toxicol 15:245-52. 2001..All compounds elicited estrogen-responsive changes in these endpoints that were individually more sensitive than uterine weight alone. We conclude that these endpoints enhance the sensitivity of the uterotropic bioassay... - Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrolR R Newbold
Developmental Endocrinology Section, Reproductive Toxicology Group, Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Carcinogenesis 21:1355-63. 2000..These data suggest that, while fertility of the DES F(2) mice appeared unaltered, increased susceptibility for tumors is transmitted from the DES 'grandmothers' to subsequent generations... - Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tractRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
Reprod Toxicol 24:253-8. 2007..These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation... - Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogensR R Newbold
Developmental Endocrinology Section, Reproductive Toxicology Group, Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cancer Res 60:235-7. 2000..These data demonstrate that both 2- and 4-hydroxyestradiol are carcinogenic metabolites. The high tumor incidence induced by 4-hydroxyestradiol supports the postulated role of this metabolite in hormone-associated cancers... - Prenatal exposure to diethylstilbestrol (DES)Retha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, North Carolina 27709, USA
Fertil Steril 89:e55-6. 2008 - Perinatal exposure to environmental estrogens and the development of obesityRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
Mol Nutr Food Res 51:912-7. 2007.... - Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in lifeRetha R Newbold
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 117:879-85. 2009..Bisphenol A (BPA), an environmental estrogen used in the synthesis of plastics, is of concern because its chemical structure resembles that of DES, and it is a "high-volume production" chemical with widespread human exposure... - Environmental estrogens and obesityRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
Mol Cell Endocrinol 304:84-9. 2009.... - Ontogeny of lactoferrin in the developing mouse uterus: a marker of early hormone responseR R Newbold
Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Biol Reprod 56:1147-57. 1997..The early appearance of LF suggests that it may play an important role in the hormonal regulation of growth and differentiation of developing uterine tissues... - Effects of endocrine disruptors on obesityRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Int J Androl 31:201-8. 2008..The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers... - Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrolR R Newbold
Developmental Endocrinology Section, Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Carcinogenesis 19:1655-63. 1998..These data suggest that the reduced fertility observed in the DES F1 female mice was not transmitted to their descendants; however, increased susceptibility to tumor formation is apparently transmitted to subsequent generations... - Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantationWendy N Jefferson
Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Biol Reprod 80:425-31. 2009.... - Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in lifeRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA
Mol Carcinog 46:783-96. 2007..These data suggested altered gene expression profiles observed 2 wk after treatment ceased, were established at the time of developmental exposure and maybe related to the initiation events resulting in carcinogenesis... - Disruption of the developing female reproductive system by phytoestrogens: genistein as an exampleWendy N Jefferson
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
Mol Nutr Food Res 51:832-44. 2007.... - Developmental exposure to estrogenic compounds and obesityRetha R Newbold
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Birth Defects Res A Clin Mol Teratol 73:478-80. 2005 - Studies of the effects of neonatal exposure to genistein on the developing female reproductive systemWendy N Jefferson
National Institute of Environmental Health Sciences, NIH, DHHS, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA
J AOAC Int 89:1189-96. 2006..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on ovarian development and reproductive function... - Assessing estrogenic activity of phytochemicals using transcriptional activation and immature mouse uterotrophic responsesWendy N Jefferson
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
J Chromatogr B Analyt Technol Biomed Life Sci 777:179-89. 2002..Furthermore, having an estrogenic "fingerprint" for each phytochemical is an essential first step in determining potential adverse effects of exposure to phytoestrogens... - Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actionsWendy N Jefferson
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Biol Reprod 67:1285-96. 2002..Given that human infants are exposed to high levels of genistein in soy-based foods, this study indicates that the effects of such exposure on the developing reproductive tract warrant further investigation... - Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant dosesWendy N Jefferson
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Biol Reprod 73:798-806. 2005..In summary, neonatal treatment with Gen caused abnormal estrous cycles, altered ovarian function, early reproductive senescence, and subfertility/infertility at environmentally relevant doses... - Neonatal exposure to the phytoestrogen genistein alters mammary gland growth and developmental programming of hormone receptor levelsElizabeth Padilla-Banks
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Endocrinology 147:4871-82. 2006..In summary, neonatal Gen exposure altered mammary gland growth and development as well as hormone receptor levels at all doses examined; higher doses of Gen led to permanent long-lasting morphological changes... - Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES)Retha R Newbold
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 30:611-6. 2002.... - Disruption of the female reproductive system by the phytoestrogen genisteinWendy N Jefferson
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, United States
Reprod Toxicol 23:308-16. 2007..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood... - Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesisR R Newbold
Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709
Cancer Res 50:7677-81. 1990..The experimental induction of these tumors will provide the basis for additional studies in mechanisms of hormonal carcinogenesis... - Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)A Yoshida
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 28:237-45. 2000.... - Response of the mouse uterus to nafoxidine stimulation: agonism and antagonismV E Quarmby
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Biol Reprod 38:945-54. 1988..These studies show that NAF stimulates some of the receptor-mediated responses attributed to an estrogen agonist in the mouse uterus; but, when co-administered with estradiol, NAF antagonizes some aspects of estrogen action... - Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assaysM D Shelby
Reproductive Toxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 104:1296-300. 1996.... - Mutagenesis of a single AT basepair in mice transgenic for PhiX174 am3, cs70. II. BrainH V Malling
Mammalian Mutagenesis Group, Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709 2233, USA
Mutat Res 444:85-95. 1999..This decrease in the revertant frequency among the treated animals was likely due to selective killing of cells with a higher spontaneous revertant frequency than cells with lower frequency... - Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 miceA Yoshida
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 27:325-33. 1999..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES... - The immature mouse is a suitable model for detection of estrogenicity in the uterotropic bioassayE Padilla-Banks
Developmental Endocrinology Section, Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 109:821-6. 2001..Because of the advantages of using mice, including lower costs, less space required, and smaller amounts of compound needed for tests, mice should be given appropriate consideration in testing paradigms for EDCs... - Impact of environmental endocrine disrupting chemicals on the development of obesityRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, and National Toxicology Program, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27713, USA
Hormones (Athens) 9:206-17. 2010..Potential mechanisms are summarized and future research needs are discussed... - Promoter CpG methylation of Hox-a10 and Hox-a11 in mouse uterus not altered upon neonatal diethylstilbestrol exposureS Li
Laboratory of Biosystems and Cancer, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Mol Carcinog 32:213-9. 2001.... - Estrogenic effect on the expression of estrogen receptor, COUP-TF, and lactoferrin mRNA in developing mouse tissuesH Shigeta
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
Mol Reprod Dev 45:21-30. 1996..These data point to the complexity of differential expression of LF gene in estrogen responsive and nonresponsive tissues during development... - Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female miceW N Jefferson
Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Biol Reprod 62:310-7. 2000..These studies provide information useful in studying the role of both ER subtypes in normal differentiation, and they provide indications of differential tissue expression during development... - Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentrationA B Moore
Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, NC 27709, USA
Hum Reprod 22:2623-31. 2007..001-50 microg/ml) on human uterine leiomyoma (UtLM) cells versus uterine smooth muscle cells (UtSMCs) in vitro... - Lactational transfer of the soy isoflavone, genistein, in Sprague-Dawley rats consuming dietary genisteinDaniel R Doerge
Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
Reprod Toxicol 21:307-12. 2006.... - Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 miceRachel L Ruhlen
Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Environ Health Perspect 116:322-8. 2008..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful... - Pharmacokinetic analysis in serum of genistein administered subcutaneously to neonatal miceDaniel R Doerge
Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
Cancer Lett 184:21-7. 2002..These results are consistent with a diminished capacity for enzymatic conjugation of genistein, based on the ontogeny, as an important determinant of estrogenicity in neonatal mice... - Dietary ethinyl estradiol exposure during development causes increased voluntary sodium intake and mild maternal and offspring toxicity in ratsSherry A Ferguson
HFT 132 Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Neurotoxicol Teratol 25:491-501. 2003..Here, while EE(2) exposure had few effects on the conventional tests of sexually dimorphic behaviors, exposure to 200 ppb in the diet appeared to feminize genetic males and hyperfeminize genetic females with regard to sodium intake... - Effect of nonylphenol on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal, and adult ratsElizabeth M Laurenzana
Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT-110, Jefferson, AR 72079, USA
Chem Biol Interact 139:23-41. 2002..These results indicate that NP can inhibit the activity of enzymes involved in testosterone synthesis, but suggest minimal effects on testosterone or testosterone-dependent endpoints via this mechanism... - A natural antioxidant mixture from spinach does not have estrogenic or antiestrogenic activity in immature CD-1 miceLiat Lomnitski
Life Science Faculty, Bar-Ilan University, Ramat-Gan, Israel
J Nutr 133:3584-7. 2003..These data suggest that NAO does not have estrogenic or antiestrogenic activity. Thus, an antioxidant mixture has been identified that does not have potentially adverse estrogenic activity... - Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007 - Multigenerational exposure to dietary nonylphenol has no severe effects on spatial learning in female ratsKatherine M Flynn
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
Neurotoxicology 23:87-94. 2002..These data suggest that multigenerational dietary nonylphenol exposure does not cause gross alterations in Morris water maze performance in young adult or middle aged ovariectomized female rats... - Effects of lifelong dietary exposure to genistein or nonylphenol on amphetamine-stimulated striatal dopamine release in male and female ratsSherry A Ferguson
Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, HFT 132, Jefferson, AR 72079, USA
Neurotoxicol Teratol 24:37-45. 2002..Dietary exposure to 200 or 750 ppm nonylphenol had no significant effects in males or females. These results suggest that dietary genistein exposure may act similarly to estradiol in augmenting amphetamine-stimulated DA release... - Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivoYing Chen
Department of Biology, Syracuse University, 130 College Place, Syracuse, New York 13244, USA
Endocrinology 148:3580-90. 2007..These findings also provide insight into the mechanism of multiple oocyte follicle formation... - In vivo effects of bisphenol A in laboratory rodent studiesCatherine A Richter
U S Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States
Reprod Toxicol 24:199-224. 2007..We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system... - Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley ratsDaniel R Doerge
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Reprod Toxicol 16:45-56. 2002..These data provide a basis for future correlations of biologic effects observed following dietary exposure in rats with those predicted from environmental exposures to humans...