Research Topics
Genomes and GenesSpecies | George W NelsonSummaryAffiliation: National Cancer Institute Country: USA Publications
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Detail Information
Publications
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDSMaureen P Martin
Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
Nat Genet 31:429-34. 2002..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection...- Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: study design, methods and feasibilityXiu Chan Guo
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA
Hum Genomics 2:365-75. 2006.... - ISHAPE: new rapid and accurate software for haplotypingOlivier Delaneau
Chaire de Bioinformatique, Conservatoire National des Arts et Metiers, Paris, France
BMC Bioinformatics 8:205. 2007..Analogously with Phase, there are 2 versions of Ishape: Ishape1 which uses a simple coalescence model for the pseudo Gibbs sampler step, and Ishape2 which uses a recombination model instead... - Using mutual information to measure the impact of multiple genetic factors on AIDSGeorge W Nelson
Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute NCI Frederick, MD 21702, USA
J Acquir Immune Defic Syndr 42:347-54. 2006..We show that 13 genetic factors can cumulatively explain 9% of slow progression to AIDS, an effect comparable to the effect of smoking on lung cancer... - Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern ChinaXiuchan Guo
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Int J Cancer 124:2942-7. 2009..7% of NPC development in NPC high risk population. These findings should have important public health implications for NPC risk reduction in endemic regions... - Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infectionMaureen P Martin
Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
J Virol 78:14053-6. 2004..87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested... - Genome-wide association study implicates PARD3B-based AIDS restrictionJennifer L Troyer
Laboratory of Genomic Diversity, SAIC Frederick, Inc, Frederick, MD 21702, USA
J Infect Dis 203:1491-502. 2011..Here we used clinically well-characterized subjects from 5 pretreatment HIV/AIDS cohorts for a genome-wide association study to identify gene associations with rate of AIDS progression... - Accounting for multiple comparisons in a genome-wide association study (GWAS)Randall C Johnson
Basic Research Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD, USA
BMC Genomics 11:724. 2010..We consider seven implementations of these commonly used methods using data from 1514 European American participants genotyped for 700,078 SNPs in a GWAS for AIDS... - Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritisGeorge W Nelson
Basic Research Program, Science Applications International Corporation-Frederick, National Cancer Institute, Frederick, MD 21702, USA
J Immunol 173:4273-6. 2004..These data emphasize the remarkable influence of KIR/HLA combinations on this disease... - Human genes that limit AIDSSTEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
Nat Genet 36:565-74. 2004..The influence and translational impact of these genes on individual and population sensitivity to AIDS is considerable... - Admixture mapping comes of ageCheryl A Winkler
Basic Science Program, SAIC Frederick, Inc, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
Annu Rev Genomics Hum Genet 11:65-89. 2010..Here, we provide a historical perspective, review AIM panels and software packages, and discuss recent successes and unexpected insights into human diseases that exhibit disparate rates across human populations... - Modulating influence on HIV/AIDS by interacting RANTES gene variantsPing An
Intramural Research Support Program, SAIC Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 99:10002-7. 2002..The diminished transcription of RANTES afforded by the In1.1C regulatory allele is consistent with increased HIV-1 spread in vivo, leading to accelerated progression to AIDS... - Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survivalSher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
J Acquir Immune Defic Syndr 48:263-71. 2008..27; P=0.01). ARG influence after HAART suggests residual HIV-1 replication, and spread continues even in patients successfully suppressing detectable viral RNA... - Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progressionCheryl A Winkler
Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
J Acquir Immune Defic Syndr 37:1534-8. 2004.... - Human immunodeficiency virus type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypesXia Jin
Infectious Disease Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
J Virol 76:12603-10. 2002..05). The data are consistent with the hypothesis that higher levels of virus-specific CTL contribute to protection against HIV disease progression in infected individuals with B*35-PY, but not in those with B*35-Px... - Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infectionHassan Javanbakht
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
Virology 354:15-27. 2006..05 for both SNPs and haplotypes. Thus, polymorphism in human TRIM5 may influence susceptibility to HIV-1 infection, a possibility that merits additional evaluation in independent cohorts... - MYH9 is a major-effect risk gene for focal segmental glomerulosclerosisJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 40:1175-84. 2008..2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans...