Carl R Lupica

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Marijuana and cannabinoid regulation of brain reward circuits
    Carl R Lupica
    Neurophysiology Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, Baltimore, MD 21224, USA
    Br J Pharmacol 143:227-34. 2004
  2. ncbi Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction
    Carl R Lupica
    Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 48:1105-16. 2005
  3. ncbi Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors
    Alexander F Hoffman
    Electrophysiology Research Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 30:545-55. 2010
  4. ncbi Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
  5. ncbi Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus
    Alexander F Hoffman
    Neurophysiology Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Eur J Neurosci 22:2387-91. 2005
  6. ncbi Dopaminergic neurons derived from BG01V2, a variant of human embryonic stem cell line BG01
    Tandis Vazin
    Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Restor Neurol Neurosci 26:447-58. 2008
  7. ncbi Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus
    Alexander F Hoffman
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:524-34. 2003
  8. ncbi Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental area
    Alice H Luo
    Behavioral Neuroscience Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Science 333:353-7. 2011
  9. ncbi Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs
    Cameron H Good
    Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 30:7900-9. 2010
  10. ncbi Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus
    Nora Laaris
    Electrophysiology Research Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropharmacology 59:121-7. 2010

Detail Information

Publications26

  1. ncbi Marijuana and cannabinoid regulation of brain reward circuits
    Carl R Lupica
    Neurophysiology Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, Baltimore, MD 21224, USA
    Br J Pharmacol 143:227-34. 2004
    ....
  2. ncbi Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction
    Carl R Lupica
    Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 48:1105-16. 2005
    ....
  3. ncbi Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors
    Alexander F Hoffman
    Electrophysiology Research Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 30:545-55. 2010
    ..Additionally, our data imply that caffeine may potentiate the effects of marijuana on hippocampal function...
  4. ncbi Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
    ..These data define consequences of repeated Delta(9)-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use...
  5. ncbi Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus
    Alexander F Hoffman
    Neurophysiology Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Eur J Neurosci 22:2387-91. 2005
    ....
  6. ncbi Dopaminergic neurons derived from BG01V2, a variant of human embryonic stem cell line BG01
    Tandis Vazin
    Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Restor Neurol Neurosci 26:447-58. 2008
    ..Similar chromosomal changes have been repeatedly observed in hESC cultures in different laboratories, indicating the importance of chromosome 17 for growth and adaptation of hESC to culture...
  7. ncbi Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus
    Alexander F Hoffman
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:524-34. 2003
    ....
  8. ncbi Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental area
    Alice H Luo
    Behavioral Neuroscience Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Science 333:353-7. 2011
    ..This transsynaptic link between hippocampus and VTA appears to be an important substrate by which environmental context regulates goal-directed behavior...
  9. ncbi Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs
    Cameron H Good
    Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 30:7900-9. 2010
    ..This suggests that different abused drugs may exert influence over distinct sets of glutamatergic afferents to VTA DA neurons which may be associated with different reinforcing or addictive properties of these drugs...
  10. ncbi Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus
    Nora Laaris
    Electrophysiology Research Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropharmacology 59:121-7. 2010
    ..Furthermore, full agonist effects of Delta(9)-THC on IPSCs likely result from a much higher expression of CB1Rs on GABA versus glutamate axon terminals in the hippocampus...
  11. ncbi NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization
    Yu Luo
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e12141. 2010
    ....
  12. ncbi Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area
    Arthur C Riegel
    Cellular Neurobiology Branch, Electrophysiology Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:11070-8. 2004
    ....
  13. ncbi The endocannabinoid anandamide inhibits the function of alpha4beta2 nicotinic acetylcholine receptors
    Charles E Spivak
    National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Unit, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Mol Pharmacol 72:1024-32. 2007
    ..These results indicate that AEA directly inhibits the function of alpha4beta2 nAChRs in a CB1 receptor-independent manner...
  14. ncbi A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells
    Tandis Vazin
    Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH, DHHS, Baltimore, MD, USA
    PLoS ONE 4:e6606. 2009
    ..The molecular nature of this effect, which has been termed "SDIA" is so far unknown. Recently, we found that factors secreted by PA6 cells provided lineage-specific instructions to induce DA differentiation of human ESC (hESC)...
  15. ncbi Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice
    Xia Li
    Neuropsychopharmacology Section, Chemical Biology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 204:1-11. 2009
    ..Effect of cannabinoid CB1 receptor deletion on cocaine's actions is controversial. This is partly based on findings in CB1-receptor-knockout (CB1(-/-)) mice with CD1 genetic background...
  16. ncbi Properties of distinct ventral tegmental area synapses activated via pedunculopontine or ventral tegmental area stimulation in vitro
    Cameron H Good
    Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Physiol 587:1233-47. 2009
    ....
  17. ncbi The solubilizing detergents, Tween 80 and Triton X-100 non-competitively inhibit alpha 7-nicotinic acetylcholine receptor function in Xenopus oocytes
    Murat Oz
    National Institute on Drug Abuse, NIH/DHHS, Intramural Research Program, Cellular Neurobiology Branch, Cellular Neurophysiology Section, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Neurosci Methods 137:167-73. 2004
    ....
  18. ncbi Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure
    Alexander F Hoffman
    Cellular Neurobiology Branch, Section on Cellular Neurophysiology, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:4815-20. 2003
    ..These data demonstrate that long-term exposure to the active ingredient of marijuana blocks synaptic plasticity in the NAc and reduces the sensitivity of GABAergic and glutamatergic synapses to both cannabinoids and opioids...
  19. ncbi Differential effects of endogenous and synthetic cannabinoids on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus Oocytes
    Murat Oz
    National Institute on Drug Abuse Intramural Research Program, Cellular Neurobiology Branch, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 310:1152-60. 2004
    ....
  20. ncbi Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease
    Cameron H Good
    Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, Baltimore, MD 21224, USA
    FASEB J 25:1333-44. 2011
    ..A full understanding of these presymptomatic cellular properties may lead to more effective early treatments of PD...
  21. ncbi Visualizing cannabinoid effects using brain slice imaging and electrophysiological approaches
    Alexander F Hoffman
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Med 123:105-12. 2006
    ....
  22. ncbi Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neurons
    William J Freed
    Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse, National Institutes of Health NIH, Baltimore, Maryland, USA
    PLoS ONE 3:e1422. 2008
    ..We initiated differentiation of human embryonic stem cells (hESCs) into dopamine neurons, obtained a purified population of neuronal precursor cells by cell sorting, and determined patterns of gene transcription...
  23. ncbi Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity
    Hong Fan
    PET Center, Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Eur J Med Chem 44:593-608. 2009
    ..Molecular modeling analysis revealed an important role of the binding of the cyano group with the CB1 binding pocket...
  24. ncbi It could be habit forming: drugs of abuse and striatal synaptic plasticity
    Gregory L Gerdeman
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Trends Neurosci 26:184-92. 2003
    ....
  25. ncbi Queer currents, steady rhythms, and drunken da neurons. Focus on "hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice"
    Carl R Lupica
    J Neurophysiol 95:585-6. 2006
  26. ncbi MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector
    Yuan Hao Chen
    Program of Clinical Medicine, Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    FASEB J 22:261-75. 2008
    ....