Research Topics
Genomes and GenesSpecies | Kyung S LeeSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Yeast Rpi1 is a putative transcriptional regulator that contributes to preparation for stationary phaseAndrew K Sobering
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Eukaryot Cell 1:56-65. 2002..Finally, we propose that inappropriate expression of RPI1 during log phase growth drives fortification of the cell wall and that this behavior is responsible for suppression of the mpkl cell lysis defect...- Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregationYoung H Kang
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell 24:409-22. 2006..Thus, Plk1 self-regulates the Plk1-PBIP1 interaction to timely localize to the kinetochores and promote proper chromosome segregation... - Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: self- versus non-self-primingKyung S Lee
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4258, USA
Cell Cycle 7:141-5. 2008..Here we discuss a recent finding that Plk1 also self-promotes its localization by generating its own PBD-docking site... - Yeast polo-like kinases: functionally conserved multitask mitotic regulatorsKyung S Lee
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bldg 37, Rm 3118, Bethesda, MD 20892, USA
Oncogene 24:217-29. 2005..In this review, common properties and distinct functions of Cdc5 and Plo1 will be discussed and compared to properties and functions of Plks in higher eucaryotic organisms... - Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interactionKyung S Lee
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell Div 3:4. 2008.... - Pinning down the polo-box domainKyung S Lee
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Chem Biol 15:415-6. 2008..In this issue of Chemistry & Biology, Reindl et al. (2008) describe the identification of a small molecule called Poloxin that appears to interfere with the function of the polo-box domain (PBD) of Plk1... - Monitoring the cell cycle by multi-kinase-dependent regulation of Swe1/Wee1 in budding yeastKyung S Lee
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cell Cycle 4:1346-9. 2005..Thus, Swe1 functions as an important cell cycle modulator that integrates multiple upstream signals from prior cell cycle events before its ultimate degradation permits passage into mitosis... - Requirement for Bbp1p in the proper mitotic functions of Cdc5p in Saccharomyces cerevisiaeChong J Park
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Biol Cell 15:1711-23. 2004..These data suggest that Bbp1pDeltaC interacts with the polo-box domain of Cdc5p, and this interaction is critical for the subcellular localization and mitotic functions of Cdc5p... - Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeastSatoshi Asano
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
EMBO J 24:2194-204. 2005..We propose that the concerted action of Cdc28/Cdk1 and Cdc5/Polo on their common substrates is an evolutionarily conserved mechanism that is crucial for effectively triggering mitotic entry and other critical mitotic events... - Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1Yoshikazu Johmura
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:11446-51. 2011..Thus, via the formation of the Nedd1-Plk1 complex and subsequent Augmin phosphorylation, Plk1 regulates spindle MT-based MT nucleation to accomplish normal bipolar spindle formation and mitotic progression... - Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cellsNak Kyun Soung
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 16:539-50. 2009..These findings provide a striking example of how a splice-generated C-terminal extension of a sperm tail-associating protein mediates unanticipated centrosomal events at distinct stages of the somatic cell cycle... - Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamicsChong J Park
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Eukaryot Cell 7:444-53. 2008..They also phosphorylated these three proteins in vitro. Taken together, these observations suggest that concerted action of Cdc28 and Cdc5 on Nud1, Slk19, and Stu2 is important for proper spindle functions... - Novel functional dissection of the localization-specific roles of budding yeast polo kinase Cdc5pJung Eun Park
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 24:9873-86. 2004..Thus, SPB- and the bud-neck-localized Cdc5p control most of the critical Cdc5p functions and downregulation of Bfa1p and Swe1p at the respective locations are two critical factors that require Cdc5p... - Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeastSatoshi Asano
Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:27090-8. 2006..Thus, Elm1 regulates the septin assembly-dependent cellular events by directly phosphorylating and activating the Gin4-dependent pathway(s)... - Coupling morphogenesis to mitotic entryKrisada Sakchaisri
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:4124-9. 2004..This mechanism links assembly of a cellular structure to passage into mitosis... - Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiaePhilip R Lee
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell Biol 22:6906-20. 2002..Our data suggest that the Bni5p-septin interaction is important for septin ring stability and function, which is in turn critical for normal cytokinesis... - Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1Sang Moon Yun
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Nat Struct Mol Biol 16:876-82. 2009..The mode of interaction between the minimal peptide and PBD may provide a template for designing therapeutic agents that target PLK1... - Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomesNak Kyun Soung
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mol Cell Biol 26:8316-35. 2006..Our results further suggest that the anti-Odf2 immunoreactive centrosomal antigen previously detected in non-germ line cells is likely hCenexin1... - Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochoresYoung H Kang
Laboratory of Metabolism, Center for Cancer Research, NCI National Institutes of Health, Bethesda, Maryland 20892 4258, USA
J Biol Chem 286:19744-57. 2011.... - Serendipitous alkylation of a Plk1 ligand uncovers a new binding channelFa Liu
Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland, USA
Nat Chem Biol 7:595-601. 2011..This work provides insights that might advance efforts to develop Plk1 PBD-binding inhibitors as potential Plk1-specific anticancer agents... - Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesisChong Jin Park
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Genetics 163:21-33. 2003..Thus, Cdc5p contributes to the activation of the Swe1p-dependent Cdc28p/Clb pathway, normal septin function, and cytokinesis... - Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026Yeon-Sun Seong
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH. Bethesda, Maryland 20892, USA
Cancer Res 63:7384-91. 2003..These data suggest that BMI-1026 could be developed as a potential anti-Cdk1 chemotherapeutic agent... - Polo-box domain: a versatile mediator of polo-like kinase functionJung Eun Park
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 37, Rm 3118, Bethesda, MD, 20892 4258, USA
Cell Mol Life Sci 67:1957-70. 2010..In this review, current understanding of the structure and functions of PBD, mode of PBD-dependent interactions and substrate phosphorylation, and other phospho-independent functions of PBD are discussed... - A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cellsYeon Sun Seong
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4258, USA
J Biol Chem 277:32282-93. 2002..We propose that, in mammalian cells, the polo-box-dependent Plk1 activity is required for proper metaphase/anaphase transition and for cytokinesis... - Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent mannerFumihiko Niiya
Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892 4256, USA
J Biol Chem 280:36502-9. 2005..Chemical induction of cytokinesis will be a valuable tool to study the initiation mechanism of cytokinesis... - Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plateJung Eun Park
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:8200-5. 2011.... - Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assayJung Eun Park
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:1725-30. 2009.... - Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiaeHyeon Su Ro
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 3D25, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:5436-41. 2002.... - The yeast Tor signaling pathway is involved in G2/M transition via polo-kinaseAkio Nakashima
Biosignal Research Center, Kobe University, Kobe, Japan
PLoS ONE 3:e2223. 2008..The C-terminal polo-box domain of Cdc5 has an inhibitory role in nuclear translocation. Taken together, our results indicate a novel function of Tor in the regulation of cell cycle and proliferation... - Centrosome replication in hydroxyurea-arrested CHO cells expressing GFP-tagged centrin2Ryoko Kuriyama
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
J Cell Sci 120:2444-53. 2007..The centrosome number increases as small foci grow in size and resolve into recognizable centrosomes. As this occurs in a random fashion, the cells arrested longer with HU induced highly heterogeneous numbers of centrosomes... - Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthmaYong Geun Kwak
Department of Pharmacology, Institute of Cardiovascular Research, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Chonju, South Korea
J Clin Invest 111:1083-92. 2003..Intratracheal administration of PI3K inhibitors or AdPTEN remarkably reduced bronchial inflammation and airway hyperresponsiveness. These findings indicate that PTEN may play a pivotal role in the pathogenesis of the asthma phenotype... - PPAR-gamma modulates allergic inflammation through up-regulation of PTENKyung S Lee
Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea
FASEB J 19:1033-5. 2005..These findings demonstrate a protective role of PPARgamma in the pathogenesis of the asthma phenotype through regulation of PTEN expression... - A set of epitope-tagging integration vectors for functional analysis in Saccharomyces cerevisiaeHyeran Sung
College of Pharmacy, Chungbuk National University, 48 Gaeshindong, Cheongju, Chungbuk, Republic of Korea
FEMS Yeast Res 5:943-50. 2005.... - Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma modelKyung S Lee
Department of Internal Medicine, Research Center for Allergic Immune Diseases, Chonbuk National University Medical School, Jeonju, South Korea
FASEB J 20:455-65. 2006..Taken together, our findings implicate that inhibition of p110delta signaling pathway may have therapeutic potential for the treatment of allergic airway inflammation...