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Species | Ho Joo LeeSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorderHo Joo Lee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 193:467-74. 2007..Thus, lamotrigine provides a pharmacological tool to differentiate if downregulation of arachidonic acid turnover is specific to drugs effective in the manic phase of bipolar disorder...- Selective remodeling of cardiolipin fatty acids in the aged rat heartHo Joo Lee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, USA
Lipids Health Dis 5:2. 2006..We therefore measured the fatty acid concentration of cardiolipin in hearts of 4, 12 and 24 month old rats that consumed one diet, adequate in fatty acids for the duration of their life... - Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammationMireille Basselin
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda 20892 0947, Maryland, USA
J Neurochem 102:761-72. 2007..To the extent that this up-regulation has neuropathological consequences, lithium might be considered for treating human brain diseases accompanied by neuroinflammation... - Chronic fluoxetine increases cytosolic phospholipase A(2) activity and arachidonic acid turnover in brain phospholipids of the unanesthetized ratHo Joo Lee
Brain Physiology and Metabolism Section National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 190:103-15. 2007..We hypothesized that chronic fluoxetine would increase the brain activity of PLA(2) and the turnover rate of arachidonic acid (AA) in phospholipids of the unanesthetized rat... - Chronic treatment of rats with sodium valproate downregulates frontal cortex NF-kappaB DNA binding activity and COX-2 mRNAJagadeesh S Rao
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Bipolar Disord 9:513-20. 2007..VPA shares many cellular and molecular targets with lithium, including reducing arachidonic acid turnover in rat brain phospholipids and cyclooxygenase-2 (COX-2) protein level and activity in rat brain... - Chronic administration of carbamazepine down-regulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortexJagadeesh S Rao
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Biol Psychiatry 61:154-61. 2007..The present study was undertaken to see whether chronic CBZ treatment also would down-regulate the AP-2 transcription factor... - Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2 and its transcription factor, activator protein-2Jagadeesh S Rao
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 102:1918-27. 2007..The changes, opposite to those found following chronic lithium or carbamazepine, are consistent with up-regulated arachidonic acid release due to excessive NR signaling and may be a contributing factor to bipolar mania... - Chronic treatment with mood stabilizers increases membrane GRK3 in rat frontal cortexRenee N Ertley
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Biol Psychiatry 61:246-9. 2007..G-protein coupled receptor supersensitivity, possibly as a result of decreased GRK, has been suggested in affective disorders... - Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E? concentration in rat brainYewon Cheon
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
J Neurochem 119:364-76. 2011.... - Brain arachidonic acid cascade enzymes are upregulated in a rat model of unilateral Parkinson diseaseHo Joo Lee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Neurochem Res 35:613-9. 2010..Thus, the tonically increased ipsilateral AA signal in the lesioned rat corresponds to upregulated cPLA(2) and COX-2 expression within the AA metabolic cascade, which may contribute to symptoms and pathology in Parkinson disease... - Antimanic therapies target brain arachidonic acid signaling: lessons learned about the regulation of brain fatty acid metabolismHo Joo Lee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Prostaglandins Leukot Essent Fatty Acids 77:239-46. 2007.... - Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorderRichard P Bazinet
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 59:401-7. 2006.... - Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized ratHo Joo Lee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
J Lipid Res 49:162-8. 2008..The changes, opposite to those after chronic administration of antimanic drugs to rats, suggest that excessive NMDA signaling via arachidonic acid may be a model of upregulated arachidonic acid turnover in brain phospholipids... - D2 but not D1 dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized ratsAbesh Kumar Bhattacharjee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S128, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 180:735-42. 2005..To determine this, we used our in vivo fatty acid method to measure signaling in response to D1 and D2 receptor agonists given acutely to unanesthetized rats... - Chronic administration of lamotrigine downregulates COX-2 mRNA and protein in rat frontal cortexHo Joo Lee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg 9, 1S 126, Bethesda, MD 20892, USA
Neurochem Res 33:861-6. 2008..Consistent with the hypothesis, lamotrigine and other mood-stabilizers have a common downregulatory action on COX-2 expression in rat brain, which may account in part for their efficacy in bipolar disorder... - Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized ratRichard P Bazinet
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg. 1S 128, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 182:180-5. 2005.... - Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake ratsMireille Basselin
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, MSC 0947, 9 Memorial Drive, Bethesda, MD 20892, USA
Neurochem Res 32:1857-67. 2007.... - Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brainRichard P Bazinet
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg S 128, Bethesda, Maryland, 20892, USA
Neurochem Res 30:597-601. 2005..39 pmol/g). Thus, the basal concentration of AEA in the brain is lower than previously thought and future studies attempting to quantify brain AEA should consider using head-focused microwave fixation to prevent anomalous results... - Immediate no-flow ischemia decreases rat heart nonesterified fatty acid and increases acyl-CoA species concentrationsDaniel Maoz
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Lipids 40:1149-54. 2005..Although it is not clear how these alterations contribute to the pathogenesis of ischemia, it is evident that future studies attempting to quantify basal levels of these metabolites could use microwave fixation... - Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized ratHo-Joo Lee
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA
Neurochem Res 30:677-83. 2005..The results of our study indicate that topiramate does not possess a pharmacological property that three drugs with proven efficacy in treating bipolar disorder have in common... - Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult ratsJames C DeMar
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Building 9, Room 1S 126, Bethesda, MD 20892-1582, USA
Biochim Biophys Acta 1761:1050-9. 2006..Thus, in rats fed even a diet containing low amounts of AA, the LA that enters brain is largely beta-oxidized, and is not a major source of AA in brain... - Haloperidol targets brain arachidonic acid signalingRichard P Bazinet
Prog Neuropsychopharmacol Biol Psychiatry 31:314-5; author reply 316. 2007