Research Topics
| Fyodor A KondrashovSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Multidimensional epistasis and the disadvantage of sexF A Kondrashov
National Center for Biotechnology Information, National Institutes of Health, Building 38A, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:12089-92. 2001..Thus, either sex exists in spite of its impact on the rate of adaptive allele replacements, or natural fitness surfaces have rather specific properties, at least at the scale of intrapopulation genetic variability...- Selection in favor of nucleotides G and C diversifies evolution rates and levels of polymorphism at mammalian synonymous sitesFyodor A Kondrashov
Section of Ecology, Behavior and Evolution, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0346, USA
J Theor Biol 240:616-26. 2006..An average genotype carries approximately 10(7) suboptimal nucleotides at synonymous sites, implying synergistic epistasis in selection against them... - Evolution of alternative splicing: deletions, insertions and origin of functional parts of proteins from intron sequencesFyodor A Kondrashov
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA
Trends Genet 19:115-9. 2003..Thus, alternative splicing often creates novel isoforms by the insertion of new, functional protein sequences that probably originated from noncoding sequences of introns... - Selection in the evolution of gene duplicationsFyodor A Kondrashov
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 3:RESEARCH0008. 2002.... - Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysisVladimir N Babenko
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda MD, USA
BMC Cancer 6:36. 2006..This conclusion is supported by accumulating experimental evidence of evolution of new functions of p53 in tumors. These findings prompted a genome-wide analysis of possible positive selection during tumor evolution... - A universal trend of amino acid gain and loss in protein evolutionI King Jordan
National Center for Biotechnology Information, NIH, Bethesda, Maryland 20894, USA
Nature 433:633-8. 2005..Thus, expansion of initially under-represented amino acids, which began over 3,400 million years ago, apparently continues to this day... - Dobzhansky-Muller incompatibilities in protein evolutionAlexey S Kondrashov
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA
Proc Natl Acad Sci U S A 99:14878-83. 2002..Data on protein structures and on cooccurrence of amino acids at different sites of multiple orthologous proteins often make it possible to provisionally identify the substitution that compensates a particular CPD... - Selection for functional uniformity of tuf duplicates in gamma-proteobacteriaFyodor A Kondrashov
Section on Ecology, Behavior and Evolution, Division of Biological Sciences, University of California at San Diego, 2218 Muir Biology Building, La Jolla, CA 92093, USA
Trends Genet 23:215-8. 2007..Thus, tuf gene copies evolve under a selective pressure that ensures their functional uniformity, and gene conversion reduces selection against amino acid substitutions that affect the function of the encoded protein, EF-Tu... - Bioinformatical assay of human gene morbidityFyodor A Kondrashov
National Center for Biotechnology Information, National Institutes of Health, 38a Center Drive, 6S602, Bethesda, MD 20892, USA
Nucleic Acids Res 32:1731-7. 2004..This classification can help to identify disease-causing genes among multiple candidates... - Distribution of the strength of selection against amino acid replacements in human proteinsLev Y Yampolsky
Department of Biological Sciences, East Tennessee State University, Johnson City, TN 37614-1710, USA
Hum Mol Genet 14:3191-201. 2005..However, differences between evolutionary fluxes of reciprocal replacements are only weakly correlated with the differences between the corresponding selection coefficients... - Evolution of a behavior-linked microsatellite-containing element in the 5' flanking region of the primate AVPR1A geneZoe R Donaldson
Neuroscience Program, Emory University, Atlanta, USA
BMC Evol Biol 8:180. 2008..Thus, evolution of these regions may have contributed to variation in social behavior in primates. We examined the structure of these regions in six ape, six monkey, and one prosimian species... - A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplicationsFyodor A Kondrashov
Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
Trends Genet 20:287-90. 2004 - Positive selection at sites of multiple amino acid replacements since rat-mouse divergenceGeorgii A Bazykin
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Nature 429:558-62. 2004..This pattern cannot be explained by correlated mutation or episodes of relaxed negative selection, but instead indicates that positive selection acts at many sites of rapid, successive amino acid replacement... - The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraintCristian I Castillo-Davis
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genome Res 14:802-11. 2004..Thus, strong purifying selection appears to act on the same core cellular processes in both mammalian and nematode lineages, whereas positive and/or relaxed selection acts on different biological processes in each lineage... - Evolution of the mouse polyubiquitin-C geneAndrey A Perelygin
Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30303, USA
J Mol Evol 55:202-10. 2002..The sequence divergence of noncoding DNA was used to estimate the frequency of unequal crossing-over events (6.3 x 10(-5) events per generation) in the Ubc gene, as well as to provide evidence of apparent selection in the poly-u gene... - Selection for short introns in highly expressed genesCristian I Castillo-Davis
Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nat Genet 31:415-8. 2002..Thus, natural selection appears to favor short introns in highly expressed genes to minimize the cost of transcription and other molecular processes, such as splicing... - A manually curated database of tetrapod mitochondrially encoded tRNA sequences and secondary structuresKonstantin Yu Popadin
Institute for Information Transmission Problems RAS, Bolshoi Karetny pereulok 19, Moscow
BMC Bioinformatics 8:441. 2007..However, an up to date, manually curated database of mitochondrially encoded tRNAs from higher animals is currently not available... - Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral stateOlga V Plotnikova
Laboratory of Molecular Brain Genetics, Research Center of Mental Health, Russian Academy of Medical Sciences, and Lomonosov Moscow State University, Moscow, Russia
Am J Hum Genet 81:32-43. 2007.... - Impact of selection, mutation rate and genetic drift on human genetic variationShamil Sunyaev
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 12:3325-30. 2003..Evolutionary and medical implications of the impact of selection on human polymorphisms are discussed... - Role of selection in fixation of gene duplicationsFyodor A Kondrashov
Rybka Research Institute, 25138 Woodfield School Rd, Gaithersburg, MD 20882, USA
J Theor Biol 239:141-51. 2006..Application of well-known methods of evolutionary genetics to accumulating data on new, polymorphic, and fixed duplication will enhance our understanding of the role of natural selection in the evolution by gene duplication... - In search of the limits of evolutionFyodor A Kondrashov
Nat Genet 37:9-10. 2005 - Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAsAndrew D Kern
Center for Population Biology, Section of Evolution and Ecology, University of California at Davis, Davis, California 95616, USA
Nat Genet 36:1207-12. 2004..At least 10%, and perhaps as many as 50%, of all nucleotide substitutions in evolving mammalian tRNAs participate in such interactions, indicating that the evolution of tRNAs proceeds along highly epistatic fitness ridges...