Research Topics
Species | Ernest S KawasakiSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Global expression analysis of prostate cancer-associated stroma and epitheliaAnnely M Richardson
Pathogenetics Unit, National Cancer Institute at Frederick, Frederick, MD, USA
Diagn Mol Pathol 16:189-97. 2007..These data provide insight into the molecular changes occurring in tumor-associated stromal cells and suggest new potential targets for future diagnostic, imaging, or therapeutic intervention...- Microarrays and the gene expression profile of a single cellErnest S Kawasaki
Advanced Technology Center, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1020:92-100. 2004..In addition, from a biologist's point of view, some bioinformatic challenges of expression analysis of single cells will be discussed... - The end of the microarray Tower of Babel: will universal standards lead the way?Ernest S Kawasaki
NCI Advanced Technology Center, Bethesda, MD 20892, USA
J Biomol Tech 17:200-6. 2006.... - Analysis of the quality of contact-pin fabricated oligonucleotide microarraysAmy X Yang
Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, RM2NN20, Building 29B, 8800 Rockville Pike, Bethesda, MD 20892, USA
Mol Biotechnol 34:303-15. 2006..Taken together, these results indicate that the quality of spotted oligonucleotide arrays should be assessed by at least two methods, autofluorescence and 9-mer hybridization before arrays are used for hybridization experiments... - Manufacturing of microarraysDavid W Petersen
SAIC Frederick, Inc, Gaithersburg, Maryland, USA
Adv Exp Med Biol 593:1-11. 2007..While the fabrication of microarrays is a very labor-intensive process, production of quality microarrays individually tailored on a project-by-project basis will help researchers shed light on future scientific questions... - Characterization of mismatch and high-signal intensity probes associated with Affymetrix genechipsYonghong Wang
SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
Bioinformatics 23:2088-95. 2007..A principal focus of this study was to investigate the nature of the MM signal intensities and demonstrate its contribution to the experimental results... - Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell linesAudrey Player
Advanced Technology Center, Microarray Facility, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Stem Cells Dev 15:315-23. 2006..Collectively, these data provide insight into the relationship between gene expression and transcriptional regulation, resulting in a reliable list of genes associated with hESCs... - Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analysesZe Hong Miao
Laboratories of Molecular Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA
Cancer Res 67:8752-61. 2007..The reported cell lines and approaches described in this article provide new tools to perform detailed functional analyses related to Top1 function... - Microarrays: the use of oligonucleotides and cDNA for the analysis of gene expressionJ Carl Barrett
Center for Cancer Research, National Cancer Institute, 31 Center Drive, MSC-2440, 20892, Bethesda, MD, USA
Drug Discov Today 8:134-41. 2003..Short- and long-oligonucleotide technologies offer such advantages, and could possibly become the major competing platform in the near future... - Nanotechnology, nanomedicine, and the development of new, effective therapies for cancerErnest S Kawasaki
National Cancer Institute, Gaithersburg, Maryland, USA
Nanomedicine 1:101-9. 2005..Finally, a new initiative--the National Cancer Institute Alliance for Nanotechnology in Cancer--will be described and discussed with respect to the scientific issues, policies, and funding... - Identification of EpCAM as a molecular target of prostate cancer stromaSumana Mukherjee
Pathogenetics Unit, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
Am J Pathol 175:2277-87. 2009..Since the stromal compartment may be particularly accessible to vascular-delivered agents, epithelial cell adhesion activating molecule could become a valuable molecular target for imaging or treatment of prostate cancer... - Laser capture microdissection, microarrays and the precise definition of a cancer cellAudrey Player
National Cancer Institute, Advanced Technology Center, Microarray Facility, Gaithersburg, MD 20877, USA
Expert Rev Mol Diagn 4:831-40. 2004..Application of these experimental approaches to cancer studies may permit a more accurate definition of the biology of the cancer cell, so that ultimately, more specific targeted therapies can be developed... - Three microarray platforms: an analysis of their concordance in profiling gene expressionDavid Petersen
Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Gaithersburg, MD 20877, USA
BMC Genomics 6:63. 2005..As part of a validation study for the long oligonucleotide arrays, we compared and contrasted expression profiles from the three formats, testing RNA from six different cell lines against a universal reference standard... - Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) projectTucker A Patterson
National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
Nat Biotechnol 24:1140-50. 2006.... - The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studiesLeming Shi
National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
BMC Bioinformatics 9:S10. 2008..The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists... - The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurementsLeming Shi
National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
Nat Biotechnol 24:1151-61. 2006..This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings... - The External RNA Controls Consortium: a progress reportShawn C Baker
Illumina, Inc, 9885 Towne Centre Drive, San Diego, California 92121, USA
Nat Methods 2:731-4. 2005..The External RNA Controls Consortium (ERCC) is developing commonly agreed-upon and tested controls for use in expression assays, a true industry-wide standard control...