M Gerschenson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    AIDS Res Hum Retroviruses 16:635-44. 2000
  2. ncbi Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria
    E L Ewings
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 24:100-5. 2000
  3. ncbi Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 4255, USA
    Ann N Y Acad Sci 918:269-81. 2000
  4. ncbi Chronic stavudine exposure induces hepatic mitochondrial toxicity in adult Erythrocebus patas monkeys
    M Gerschenson
    Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    J Hum Virol 4:335-42. 2001
  5. ncbi Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetuses
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
    Reprod Toxicol 15:525-31. 2001
  6. ncbi ATP synthesis is coupled to rat liver mitochondrial RNA synthesis
    S F DasGupta
    Section on Brain Physiology and Metabolism, NIA, NIH, Bethesda, MD, USA
    Mol Cell Biochem 221:3-10. 2001

Collaborators

Detail Information

Publications6

  1. ncbi Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    AIDS Res Hum Retroviruses 16:635-44. 2000
    ..Furthermore, a dose-dependent depletion of mitochondrial DNA levels was observed in both tissues. The data demonstrate that transplacental AZT exposure causes cardiac and skeletal muscle mitochondrial myopathy in the patas monkey fetus...
  2. ncbi Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria
    E L Ewings
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 24:100-5. 2000
    ..Thus, in fetal patas monkeys given a human equivalent daily dose of AZT during the last half of pregnancy, mitochondria in the fetal cerebrum appear to sustain moderate damage, while the fetal cerebellum mitochondria were not effected...
  3. ncbi Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 4255, USA
    Ann N Y Acad Sci 918:269-81. 2000
    ..It is therefore possible that the placenta, which is a readily accessible tissue, might be an indicator of potential mitochondrial toxicity in human pregnancies involving nucleoside analog drug exposure...
  4. ncbi Chronic stavudine exposure induces hepatic mitochondrial toxicity in adult Erythrocebus patas monkeys
    M Gerschenson
    Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    J Hum Virol 4:335-42. 2001
    ....
  5. ncbi Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetuses
    M Gerschenson
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
    Reprod Toxicol 15:525-31. 2001
    ..Therefore, cisplatin-induced mitochondrial toxicity in maternal rat kidney is severe, while damage to mitochondria in fetal kidney and liver, occurring as a result of the transplacental drug exposure, appears to be mild...
  6. ncbi ATP synthesis is coupled to rat liver mitochondrial RNA synthesis
    S F DasGupta
    Section on Brain Physiology and Metabolism, NIA, NIH, Bethesda, MD, USA
    Mol Cell Biochem 221:3-10. 2001
    ..At ADP concentrations above 2 mM, RNA synthesis decreased. These results demonstrate that mitochondrial transcription is tightly coupled to ATP levels...