Research Topics
Genomes and Genes
| J L GaoSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Impaired antibacterial host defense in mice lacking the N-formylpeptide receptorJ L Gao
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 189:657-62. 1999..These results indicate that FPR functions in antibacterial host defense in vivo...- Differential expansion of the N-formylpeptide receptor gene cluster in human and mouseJ L Gao
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 51:270-6. 1998..These results suggest that the FPR gene cluster has undergone differential expansion in mammals with FPRL2, Fpr-rs2, Fpr-rs3, Fpr-rs4, and Fpr-rs5 arising after divergence of human and mouse... - Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9C A Kozak
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 29:294-6. 1995..Thus, like chemokine genes and alpha chemokine receptor genes, this group of beta chemokine receptor genes arose by tandem duplication... - N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes. Molecular characterization of FPR2, a second mouse neutrophil FPRJ K Hartt
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 190:741-7. 1999.... - Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brainH L Tiffany
Molecular Signaling and Genetic Immunotherapy Sections, Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20982, USA
J Biol Chem 276:23645-52. 2001..Amyloid-beta was also a specific agonist at the human counterpart of FPR2, the FPR-like 1 receptor. These results suggest a unified signaling mechanism for linking amyloid-beta to phagocyte chemotaxis and oxidant stress in the brain... - The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPRT S Liang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 167:6609-14. 2001..Thus, spinorphin blocks fMLF-induced neutrophil chemotaxis by acting as a specific antagonist at the fMLF receptor subtype FPR... - Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1J L Gao
Laboratory of Host Defenses, National Institute of Allergy and Infectio us Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 185:1959-68. 1997..Thus CCR1 has nonredundant functions in hematopoiesis, host defense, and inflammation... - Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptorJ L Gao
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
J Exp Med 177:1421-7. 1993..It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus... - Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domainsJ L Gao
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 268:25395-401. 1993.... - Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1RA Sahagun-Ruiz
Molecular Signaling Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1886, USA
Genes Immun 2:335-42. 2001..Thus FPR1 and FPRL1, though they originated from a common gene, appear to have undergone markedly different evolutionary events... - Cloning, mRNA distribution, and functional expression of an avian counterpart of the chemokine receptor/HIV coreceptor CXCR4T S Liang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Leukoc Biol 69:297-305. 2001.... - Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2BC Combadiere
Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 270:29671-5. 1995..These data suggest that monocyte responses to MCP-3 could be mediated by both CC CKR2B and CC CKR1, whereas eosinophil responses to MCP-3 could be mediated by CC CKR1... - Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophilsT S Liang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
Biochem Biophys Res Commun 270:331-5. 2000..Our results suggest that FPR2 specifically mediates mouse neutrophil migration in response to SAA... - Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309H L Tiffany
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 186:165-70. 1997..The apparent monogamous relationship between I-309 and CCR8 is unusual among known CC chemokines and known CC chemokine receptors. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis... - Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptorJ L Gao
Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 270:17494-501. 1995..These data identify potentially important new targets for beta chemokine action in the mouse... - A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4RX Deng
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD, USA
Blood 94:1165-73. 1999..This may explain, at least in part, the initial activation of innate immune responses in HIV-1-infected patients followed by immune suppression... - Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytesM Durstin
Department of Physiology, University of Connecticut Health Center, Farmington
Biochem Biophys Res Commun 201:174-9. 1994..In contrast, FPRL2 RNA is detectable in monocytes but not in neutrophils, and its product could not be activated by N-formylpeptides. Thus, the regulation of FPRL2 gene expression in vivo differs from FPR1 and FPRL1... - Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infectionI A Khan
Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 166:1930-7. 2001..Our results suggest that CCR1-dependent migration of neutrophils to the blood and tissues may have a significant impact in controlling parasite replication... - Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1Y Le
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, International Corporation Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
J Neurosci 21:RC123. 2001..Moreover, FPRL1 is expressed at high levels by inflammatory cells infiltrating senile plaques in brain tissues from AD patients. Thus, FPRL1 may mediate inflammation seen in AD and is a potential target for developing therapeutic agents... - Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1J Y Hu
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA
J Leukoc Biol 70:155-61. 2001..Since MMK-1 is one of the most potent FPRL1-specific agonists identified so far, it can serve as a modulator of the host defense and a useful agent for further studying the signaling and function of FPRL1... - A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cellsS B Su
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
J Exp Med 189:395-402. 1999..In contrast, SAA was not a ligand or agonist for FPR, the high affinity fMLP receptor. Thus, SAA is the first chemotactic ligand identified for FPRL1. Our results suggest that FPRL1 mediates phagocyte migration in response to SAA... - Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1S Zhang
Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202, USA
J Immunol 162:4938-42. 1999..2 nM and 1.1 nM, respectively. We conclude that CCR1 is a receptor mediating responses to both MIP-1 alpha and Lkn-1 on neutrophils and produces different biological responses depending on the ligand bound... - MIP-1alpha is produced but it does not control pulmonary inflammation in response to respiratory syncytial virus infection in miceJ B Domachowske
Department of Pediatrics, State University of New York Upstate Medical Center, Syracuse, New York 13210, USA
Cell Immunol 206:1-6. 2000.... - The chemokine macrophage-inflammatory protein-1 alpha and its receptor CCR1 control pulmonary inflammation and antiviral host defense in paramyxovirus infectionJ B Domachowske
Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY, USA
J Immunol 165:2677-82. 2000..These results suggest that the MIP-1 alpha/CCR1-mediated acute inflammatory response protects mice by delaying the lethal sequelae of infection... - Dominant myelopoietic effector functions mediated by chemokine receptor CCR1H E Broxmeyer
Department of Microbiology Immunology, The Department of Medicine, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Exp Med 189:1987-92. 1999..CCR1 is not a dominant receptor for MIP-1alpha suppression of MPC proliferation, but it does negatively impact G-CSF-induced MPC mobilization...