Ken ichi Fujita

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF
    Ken ichi Fujita
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cancer 6:71. 2007
  2. ncbi Ubiquitination and TNFR1 signaling
    Ken ichi Fujita
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3016A, 9000 Rockville Pike, Bethesda, MD 20892 4256, USA
    Results Probl Cell Differ 49:87-114. 2009
  3. ncbi A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface
    Sudhanshu Shukla
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Apoptosis 16:162-73. 2011
  4. ncbi TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)
    Ken ichi Fujita
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
    Autophagy 7:552-4. 2011
  5. ncbi CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation
    Wentao Liao
    Laboratory of Immune Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Curr Biol 18:641-9. 2008
  6. ncbi Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
    Ken ichi Fujita
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:1427-32. 2011
  7. ncbi Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis
    Masaaki Iigo
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cytokine 25:36-44. 2004

Collaborators

  • Siegfried Janz
  • Wafik S El-Deiry
  • M A S Moore
  • Sudhanshu Shukla
  • Qi Xiao
  • Srinivasa M Srinivasula
  • Susan Garfield
  • Wentao Liao
  • Masaaki Iigo
  • ZhiYong Liao
  • Vladimir Tchikov
  • Stefan Schütze
  • Stephen Wincovitch
  • Dietrich Conze
  • Wensheng Yang
  • Hiroshi Nomoto
  • Jun Satoh
  • Syuji Kojima
  • Eiji Matsuda
  • Mariko Shimamura
  • David B Alexander
  • Hiroyuki Tsuda

Detail Information

Publications7

  1. ncbi Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF
    Ken ichi Fujita
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cancer 6:71. 2007
    ....
  2. ncbi Ubiquitination and TNFR1 signaling
    Ken ichi Fujita
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3016A, 9000 Rockville Pike, Bethesda, MD 20892 4256, USA
    Results Probl Cell Differ 49:87-114. 2009
    ..Here, we discuss the current understanding of how these proteins regulate TNFR1 signaling...
  3. ncbi A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface
    Sudhanshu Shukla
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Apoptosis 16:162-73. 2011
    ..Our data suggest that PP1201 functions as an anti-apoptotic protein and its increased expression in vascular cells can contribute to homeostasis by reducing Fas trafficking to the cell membrane...
  4. ncbi TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)
    Ken ichi Fujita
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
    Autophagy 7:552-4. 2011
    ..This study revealed a signaling role for p62, distinct from its known function as a bacterial-targeting factor, which might be critical for cellular stress response during infection...
  5. ncbi CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation
    Wentao Liao
    Laboratory of Immune Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Curr Biol 18:641-9. 2008
    ..Internalization of the receptor complex plays an important regulatory role in TNF signaling...
  6. ncbi Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
    Ken ichi Fujita
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:1427-32. 2011
    ..These findings indicate that TLR4-driven induction of p62 plays an essential role in the formation and the autophagic degradation of ALIS, which might be critical for regulating host defense...
  7. ncbi Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis
    Masaaki Iigo
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cytokine 25:36-44. 2004
    ....