Research Topics
Species | D DerseSummaryAffiliation: National Cancer Institute Country: USA Publications
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Detail Information
Publications
Infectious transmission and replication of human T-cell leukemia virus type 1David Derse
Retrovirus Gene Expression Section, HIV Drug Resistance Program, NCI Frederick, Frederick, MD 21702 1201, USA
Front Biosci 9:2495-9. 2004..We are determining whether this block is conferred by the viral replication enzymes, results from the actions of cellular restriction factors, reflects the need for cell-cell contact, or is caused by a combination of these factors...- Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsidDavid Derse
HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702 1201, USA
Proc Natl Acad Sci U S A 104:2915-20. 2007..Elements within the C-terminal extension of the NC domain are highly conserved among the primate T cell leukemia viruses, but this extension is absent in all other retroviral NC proteins... - Virology. Forced entry--or does HTLV-I have the key?David Derse
Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
Science 299:1670-1. 2003 - Examining human T-lymphotropic virus type 1 infection and replication by cell-free infection with recombinant virus vectorsD Derse
Basic Research Laboratory, National Cancer Institute, NCI Frederick, Frederick, Maryland 21702, USA
J Virol 75:8461-8. 2001..Thus, the low infectivity of HTLV-1 is determined in large part by properties of the core particle and by the efficiency of postentry processes... - X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitroD Derse
Division of Basic Sciences, National Cancer Institute, Frederick, Maryland, USA
Virology 237:123-8. 1997..Thus, ORFs X-I and X-II are not essential for virus infectivity, replication, gene expression, or T-cell immortalization in vitro... - Bovine immunodeficiency virus tat gene: cloning of two distinct cDNAs and identification, characterization, and immunolocalization of the tat gene productsS E Fong
Laboratory of Cell and Molecular Structure, SAIC Frederick, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
Virology 233:339-57. 1997..The present studies demonstrate that BIV Tat parallels the primate lentiviral Tats in structure and biochemistry but is not interchangeable with the latter... - Binding sites for Rev and ASF/SF2 map to a 55-nucleotide purine-rich exonic element in equine infectious anemia virus RNAD Derse
Basic Research Laboratory, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702
J Biol Chem 276:18960-7. 2001..These data suggest that EIAV Rev-induced exon skipping observed in vivo may be initiated by simultaneous binding of Rev and SR proteins to the RRE that alter the subsequent assembly or catalytic activity of the spliceosomal complex... - The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1Gisela Heidecker
National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
J Virol 81:9769-77. 2007..Additionally, we show that the PPPY(-) mutant Gag exerts a strong dominant-negative effect on the budding of wild-type Gag, further supporting the importance of recruitment of WWP1 to achieve particle assembly... - Phenotypic and genotypic comparisons of human T-cell leukemia virus type 1 reverse transcriptases from infected T-cell lines and patient samplesMichael S Mitchell
National Cancer Institute, Bldg 535 134, Frederick, MD 21702, USA
J Virol 81:4422-8. 2007..The molecular clone from CS-1 cells had four amino acid differences from the consensus sequence and yielded infectious titers that were approximately eight times lower than those of vectors encoding a consensus reverse transcriptase... - The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag proteinDmitriy Mazurov
HIV Drug Resistance Program, NCI Frederick, Frederick, Maryland 21702 1201, USA
J Biol Chem 282:3896-903. 2007..HTLV-1 MA also interacted with the inner loop of CD81. Thus, association of HTLV-1 Gag with tetraspanin-enriched microdomains is mediated by the inner loops of CD81 and CD82... - Human T-cell leukemia virus type 1 Tax protein down-regulates pre-T-cell receptor alpha gene transcription in human immature thymocytesMelanie Wencker
Virologie Humaine U758, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
J Virol 81:301-8. 2007..They further provide evidence that Tax can interfere with an important checkpoint during T-cell differentiation in the thymus... - Synthesis, processing, and composition of the virion-associated HTLV-1 reverse transcriptaseMichael S Mitchell
HIV Drug Resistance Program, NCI-Frederick, Maryland 21702, USA
J Biol Chem 281:3964-71. 2006..Immunoprecipitation of an epitope-tagged p62 subunit coprecipitated p49, indicating that the HTLV-1 RT complex can exist as a p62/p49 heterodimer analogous to the RT of HIV-1 (p66/p51)... - HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membraneDmitriy Mazurov
National Cancer Institute, HIV Drug Resistance Program, Bld 535, Rm 110, NCI Frederick, Frederick, MD 21702 1201, USA
Virology 346:194-204. 2006..Our data suggest that once at the plasma membrane, HTLV-1 virion components associate with CD82-containing microdomains, which may facilitate the mobilization of nascent virions to sites of intercellular adhesion... - Intersubunit disulfide isomerization controls membrane fusion of human T-cell leukemia virus EnvKejun Li
Department of Biosciences and Nutrition, Karolinska Institute, S 141 57 Huddinge, Sweden
J Virol 82:7135-43. 2008..Thus, this extends the applicability of the isomerization model from gammaretroviruses to deltaretroviruses... - A novel protease processing site in the transframe protein of human T-cell leukemia virus type 1 PR76(gag-pro) defines the N terminus of RTGisela Heidecker
Basic Research Laboratory, NCI Frederick, Building 567, Room 154, Frederick, MD 21702 1201, USA
J Virol 76:13101-5. 2002..Neither mutation alone or in combination caused changes in the amounts or processing patterns of the Gag polyprotein, indicating that protease is active independent of its C terminus... - Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell linesHye Kyung Chung
Basic Research Laboratory, Center for Cancer Research, NCI Frederick, Frederick, MD 21702 1201, USA
Blood 102:4130-6. 2003..As IL-13 plays key roles in tumor immunosurveillance, asthma, and central nervous system inflammation, it may contribute to the pathophysiology of HTLV-1-associated diseases... - Roles of viral and cellular proteins in the expression of alternatively spliced HTLV-1 pX mRNAsGerald L Princler
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA
Virology 317:136-45. 2003..Ectopic expression of hnRNP A1 did not affect pX splice site utilization, but increased exon skipping, as the level of pX-p21rex mRNA was increased by almost 10-fold... - HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replicationChristophe Nicot
Animal Models and Retroviral Vaccines Section, National Cancer Institute, National Institutes of Health, 41/D804, Bethesda, Maryland 20892, USA
Nat Med 10:197-201. 2004..Because Tex and Rex are positive regulators of viral gene expression, their inhibition by p30(II) reduces virion production. p30(II) inhibits virus expression by reducing Tax and Rex protein expression... - Late assembly motifs of human T-cell leukemia virus type 1 and their relative roles in particle releaseGisela Heidecker
Molecular Biology of Retroviruses Section, Basic Research Lab, National Cancer Institute NIH, NCI Frederick, Bldg 567, Rm 155, Frederick, MD 21702 1201, USA
J Virol 78:6636-48. 2004..Very few tethered immature particles could be detected in these samples, suggesting that budding is impaired at an earlier step than in other retroviruses... - Antiretroviral potential of human tripartite motif-5 and related proteinsFengwen Zhang
Aaron Diamond AIDS Research Center and the Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
Virology 353:396-409. 2006..However, endogenous owl monkey TRIMCyp potently inhibited an SIV(AGM) strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins... - Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitorsShawn A Hill
Basic Research Laboratory, Center for Cancer Research, Frederick, Maryland, USA
J Infect Dis 188:424-7. 2003..The susceptibility of HTLV-I to 6 nucleoside reverse-transcriptase inhibitors was examined. HTLV-I replication was inhibited by tenofovir, abacavir, lamivudine, zalcitabine, stavudine, and zidovudine... - Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retrovirusesDavid Derse
HIV Drug Resistance Program, Laboratory of Molecular Technology, SAIC Frederick, Inc, NCI Frederick, 915 Toll House Avenue, Frederick, MD 21702, USA
J Virol 81:6731-41. 2007..Our results show that retroviruses that engender different insertional mutagenesis risks can have similar integration profiles... - cis-Acting and trans-acting modulation of equine infectious anemia virus alternative RNA splicingHuey-Jane Liao
Basic Research Program, SAIC-Frederick, Frederick, MD 21702, USA
Virology 323:131-40. 2004..Over-expression of SF2/ASF in cells transfected with wild-type provirus constructs inhibited splicing but did not significantly alter exon 3 skipping...