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Genomes and Genes | C CicalaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cellsClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
Virology 345:105-14. 2006..These observations provide insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs...- HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replicationClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:9380-5. 2002..These observations provide evidence that envelope-mediated signaling contributes to the productive infection of HIV in suboptimally activated T cells... - Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelopeC Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 163:420-6. 1999..Activation of this signaling pathway by HIV-1 envelope may be an important pathogenic mechanism of dysregulated cellular activation and trafficking during HIV infection... - HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cellsC Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:1178-83. 2000..En-velope treatment of lymphocytes led to the cleavage of FAK in a manner consistent with caspase-mediated cleavage... - CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopesJ Arthos
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 74:6418-24. 2000..The data presented here are consistent with this hypothesis and suggest that the differential capacity of viral envelopes to signal through CCR5 may influence their ability to replicate in macrophages... - Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesisA Kinter
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Immunol Rev 177:88-98. 2000..Finally, the interaction between chemokine receptors and chemokines or HIV envelope has significant effects on cellular functions which likely play a role in HIV pathogenesis... - CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32O J Cohen
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 1876, USA
J Virol 72:6215-7. 1998..Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Delta32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals... - Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIVM E Ruiz
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1576, USA
J Immunol 161:4169-76. 1998.... - Structural basis for the interaction between focal adhesion kinase and CD4Marie Line Garron
INSERM, UMR554, 34090 Montpellier, France
J Mol Biol 375:1320-8. 2008..In infected cells, HIV-1 Nef may displace FAK from CD4 to protect the cells from apoptosis... - HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cellsElena Martinelli
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:3396-401. 2007.... - R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cellsClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:3746-51. 2006..Additionally, signaling by R5 gp120 may facilitate the transmission of R5 viruses by inducing a permissive environment for HIV replication... - Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapyNeil Gupta
Laboratory of Immunoregulation, NIAID, NIH Bldg. #10 6A08, 9000 Rockville Pike, Bethesda MD 20892, USA
Virology 332:491-7. 2005..NK cells pre-armed in this manner retain the capacity to kill targets over an extended period of time. This strategy may have application to other disease states including various viral infections and cancers... - HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosisAudrey L Kinter
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:2449-55. 2003.... - HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesPeter D Kwong
Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 420:678-82. 2002..Because this solution is available for cell-surface receptors but not for most antibodies, conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization... - The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cellsJames Arthos
Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland 20892, USA
Virology 292:98-106. 2002..However, envelope--coreceptor interactions, and in particular, envelope--CXCR4 interactions, can contribute to this process... - Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategiesJames Arthos
Laboratory of Immunoregulation, NIAID, and the Molecular Interactions Resource Division of Bioengineering and Physical Science, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:11456-64. 2002..This protein does not enhance viral replication at suboptimal concentrations. These observations may aid in the design of new therapeutics and vaccines... - HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cellsJames Arthos
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 9:301-9. 2008..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1... - Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitorSimon Cocklin
Drexel University College of Medicine, 11313 New College Building, 245 N 15th St, Philadelphia, PA 19102, USA
J Virol 81:3645-8. 2007..The combined results suggest that the HNG-105 molecule may be effective across the HIV-1 subtypes, and they highlight its potential as a lead for developing therapeutic and microbicidal agents to help combat the spread of AIDS...