Edward Chan

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNF-alpha
    E D Chan
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Biochem Biophys Res Commun 253:790-6. 1998
  2. ncbi Current medical treatment for tuberculosis
    Edward D Chan
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    BMJ 325:1282-6. 2002
  3. ncbi What is the role of nitric oxide in murine and human host defense against tuberculosis?Current knowledge
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center and Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 25:606-12. 2001
  4. ncbi Redox paradox: effect of N-acetylcysteine and serum on oxidation reduction-sensitive mitogen-activated protein kinase signaling pathways
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 24:627-32. 2001
  5. ncbi Vertebral osteomyelitis due to infection with nontuberculous Mycobacterium species after blunt trauma to the back: 3 examples of the principle of locus minoris resistentiae
    E D Chan
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Clin Infect Dis 32:1506-10. 2001
  6. ncbi Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Infect Immun 69:2001-10. 2001
  7. ncbi IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Cell Physiol 280:C441-50. 2001
  8. ncbi Immunologic diagnosis of tuberculosis: a review
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, CO, USA
    Tuber Lung Dis 80:131-40. 2000
  9. ncbi Diagnosis of tuberculosis by a visually detectable immunoassay for lipoarabinomannan
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, and Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 161:1713-9. 2000
  10. ncbi Calcium deposition with or without bone formation in the lung
    Edward D Chan
    Division of Pulmonary Sciences, University of Colorado Health Sciences Center, Denver, USA
    Am J Respir Crit Care Med 165:1654-69. 2002

Research Grants

  1. Host defense functions of M. tuberculosis lipoglycan
    Edward Chan; Fiscal Year: 2005

Collaborators

Detail Information

Publications34

  1. ncbi Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNF-alpha
    E D Chan
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Biochem Biophys Res Commun 253:790-6. 1998
    ....
  2. ncbi Current medical treatment for tuberculosis
    Edward D Chan
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    BMJ 325:1282-6. 2002
  3. ncbi What is the role of nitric oxide in murine and human host defense against tuberculosis?Current knowledge
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center and Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 25:606-12. 2001
    ..In a Darwinian fashion, it also appears that certain strains of M. tuberculosis have evolved strategies to combat the toxic effects of NO...
  4. ncbi Redox paradox: effect of N-acetylcysteine and serum on oxidation reduction-sensitive mitogen-activated protein kinase signaling pathways
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 24:627-32. 2001
    ..Because serum can significantly alter the redox state, these findings highlight the importance of the local redox milieu in signal transduction...
  5. ncbi Vertebral osteomyelitis due to infection with nontuberculous Mycobacterium species after blunt trauma to the back: 3 examples of the principle of locus minoris resistentiae
    E D Chan
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Clin Infect Dis 32:1506-10. 2001
    ..We describe 3 patients with vertebral osteomyelitis due to infection with nontuberculous mycobacterial organisms that was precipitated by blunt trauma; these 3 unusual cases illustrate the principle of locus minoris resistentiae...
  6. ncbi Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Infect Immun 69:2001-10. 2001
    ..These results indicate that combined IFN-gamma and ManLAM stimulation induced iNOS and NO. expression and that MEK1-ERK, MKK7-JNK, IKK-NF-kappaB, and p38mapk signaling pathways play important regulatory roles...
  7. ncbi IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Cell Physiol 280:C441-50. 2001
    ..These results indicate that the MAPKs are important regulators of iNOS-NO. expression by IFN-gamma + LPS...
  8. ncbi Immunologic diagnosis of tuberculosis: a review
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, CO, USA
    Tuber Lung Dis 80:131-40. 2000
    ..Furthermore, the higher costs and greater training required in performing these tests makes it important that future studies also assess whether their use affects patient outcomes in management of TB...
  9. ncbi Diagnosis of tuberculosis by a visually detectable immunoassay for lipoarabinomannan
    E D Chan
    Division of Pulmonary Sciences and Critical Care Medicine, and Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 161:1713-9. 2000
    ..We conclude that anti-LAM IgG immunoassay is relatively sensitive and specific for active TB and thus, a potentially useful screening test for active TB...
  10. ncbi Calcium deposition with or without bone formation in the lung
    Edward D Chan
    Division of Pulmonary Sciences, University of Colorado Health Sciences Center, Denver, USA
    Am J Respir Crit Care Med 165:1654-69. 2002
    ....
  11. ncbi Pulmonary edema fluid antioxidants are depressed in acute lung injury
    Russell P Bowler
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Crit Care Med 31:2309-15. 2003
    ..In acute lung injury, the distal airspace antioxidants ascorbate, urate, and glutathione may play a role in attenuating lung injury...
  12. ncbi Treatment and outcome analysis of 205 patients with multidrug-resistant tuberculosis
    Edward D Chan
    Department of Medicine, Program in Cell Biology and Division of Biostatistics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Crit Care Med 169:1103-9. 2004
    ..The improvement was statistically significant for surgery and among older patients for fluoroquinolone therapy...
  13. ncbi Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury
    Russell P Bowler
    National Jewish Medical and Research Center, K736a, 1400 Jackson St, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1095-104. 2004
    ..Nearly all ALI patients also had protein spots that indicate truncation or other posttranslational modifications. Several of these novel changes could serve as new biomarkers of lung injury...
  14. ncbi Airway antioxidants and oxidative stress as predictors of sputum atypia and airflow obstruction
    Russell P Bowler
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 125:127S-8S. 2004
  15. ncbi Pulmonary infection with Mycobacterium neoaurum identified by 16S ribosomal DNA sequence
    Yoshikazu Morimoto
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    J Infect 54:e227-31. 2007
    ..We describe the first case of pulmonary infection with M. neoaurum. We speculate that unrecognized aspiration and long-term corticosteroid therapy predisposed our patient to this rare mycobacterial infection...
  16. ncbi The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis
    Xiyuan Bai
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Biochem Biophys Res Commun 307:86-91. 2003
    ..CK2beta interacts specifically with Tctex4 both in a yeast two-hybrid system and in an in vitro interaction assay. Northern blot and in situ hybridization showed that Tctex4 is a novel gene that is expressed in mouse testis...
  17. ncbi Mycoplasma pneumoniae antigens stimulate interleukin-8
    Kathryn Chmura
    Department of Medicine, National Jewish Medical and Research Center, Denver CO 80206, USA
    Chest 123:425S. 2003
  18. ncbi Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells
    Kathryn Chmura
    Department of Medicin, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Physiol Lung Cell Mol Physiol 295:L220-30. 2008
    ..pneumoniae are also known to have anti-inflammatory effects. Whereas clarithromycin, azithromycin, and moxifloxacin individually were able to inhibit TNF-alpha-induction of IL-8, each failed to inhibit MMF-induction of IL-8...
  19. ncbi Pseudomonas aeruginosa twitching motility-mediated chemotaxis towards phospholipids and fatty acids: specificity and metabolic requirements
    Rhea M Miller
    Department of Microbiology, University of Colorado Denver, Aurora, CO 80045, USA
    J Bacteriol 190:4038-49. 2008
    ....
  20. ncbi Corticosteroids for bacterial meningitis
    Edward D Chan
    N Engl J Med 358:1399; author reply 1400-1. 2008
  21. ncbi Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages
    Edward D Chan
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Scand J Infect Dis 39:690-6. 2007
    ..abscessus infection of monocyte-derived macrophages by up to 65% (p<0.01). AAT may be an anti-RGM host-defense factor, and anomalous AAT phenotypes or AAT deficiency may constitute risk factors for pulmonary disease due to RGM...
  22. ncbi Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages
    Hubert M Tse
    Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 168:825-33. 2002
    ..Therefore, the data suggest that induction of the MAPK pathway during uptake of bacteria is instrumental in determining the eventual fate of the bacteria...
  23. ncbi Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  24. ncbi Pulmonary capillary hemangiomatosis: an immunohistochemical analysis of vascular remodeling in a fatal case
    Andrew Sullivan
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Chest 128:576S. 2005
  25. ncbi Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, and Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Immunol 17:1399-408. 2005
    ..Leptin replacement restored the reduced IFNgamma response observed in ob/ob mice. Mortality did not differ between ob/ob and Wt mice. These data suggest that leptin plays a role in the early immune response to pulmonary tuberculosis...
  26. ncbi A middle-aged woman with recurrent respiratory infections
    Kathryn Chmura
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Respiration 72:427-30. 2005
  27. ncbi Dysphagia, chest pain, and refractory asthma in a 42-year-old woman
    Robert A Winn
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine, Campus Box C272, 4200 E Ninth Ave, Denver, CO 80262, USA
    Chest 126:1694-7. 2004
  28. ncbi Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis
    Xiyuan Bai
    Department of Medicine, University of Colorado School of Medicine, Denver, CO 80206, USA
    Tuberculosis (Edinb) 84:375-85. 2004
    ..CONCLUSION: Th(1) cytokines and TGFbeta are increased while Th(2) cytokines are decreased in well-formed pulmonary granulomas of TB patients compared to controls...
  29. ncbi Interleukin-18 expression in cystic fibrosis lungs
    Edward D Chan
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA
    Chest 121:84S-85S. 2002
  30. ncbi Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis
    Gwendolyn S Kerby
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 283:L188-97. 2002
    ..We speculate that augmentation of macrophage apoptosis in CF airways may result in decreased clearance of neutrophils and in deficiencies in the elimination of common CF pathogens...
  31. ncbi Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis
    Hyung-Seok Choi
    Department of Medicine, Program in Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 166:178-86. 2002
    ..This descriptive study provides evidence that in human TB, NOS isoenzymes and NO are present in specialized areas of the tuberculous granulomas; their precise role in human TB remains to be determined...
  32. ncbi Multiple pulmonary nodules in an HIV-positive man on highly active antiretroviral therapy
    Robert A Winn
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 122:1840-3. 2002
  33. ncbi Role of the NF-kappaB signaling pathway and kappaB cis-regulatory elements on the IRF-1 and iNOS promoter regions in mycobacterial lipoarabinomannan induction of nitric oxide
    Kristin R Morris
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Infect Immun 71:1442-52. 2003
    ..The influence of mitogen-activated protein kinases on IFN-gamma plus ManLAM induction of iNOS-NO(.) is not due to any effects on ManLAM induction of NF-kappaB...
  34. ncbi Treatment outcomes in extensively resistant tuberculosis
    Edward D Chan
    N Engl J Med 359:657-9. 2008

Research Grants5

  1. Host defense functions of M. tuberculosis lipoglycan
    Edward Chan; Fiscal Year: 2005
    ..3. To elucidate the role of the TLRs, MAPK and NFkB signaling pathways, and ManLAM in controlling the growth of M. tuberculosis in mouse and human macrophages and to correlate effects on growth with NO* and TNFa expression. ..