Research Topics
| Sara R ZwartSummaryAffiliation: NASA Ames Research Center Country: USA Publications
|
Detail Information
Publications
Saturation diving alters folate status and biomarkers of DNA damage and repairSara R Zwart
Universities Space Research Association, Houston, Texas, United States of America
PLoS ONE 7:e31058. 2012..In addition, folate status decreases quickly in this environment, and this study provides evidence that folate requirements may be greater when body iron stores and DNA damage repair responses are elevated...- Capacity of omega-3 fatty acids or eicosapentaenoic acid to counteract weightlessness-induced bone loss by inhibiting NF-kappaB activation: from cells to bed rest to astronautsSara R Zwart
Universities Space Research Association, NASA Johnson Space Center, Human Adaptation and Countermeasures Division, Houston, TX 77058, USA
J Bone Miner Res 25:1049-57. 2010..62, p < .05). Together these data provide mechanistic cellular and preliminary human evidence of the potential for EPA to counteract bone loss associated with spaceflight... - Stability of analytes related to clinical chemistry and bone metabolism in blood specimens after delayed processingSara R Zwart
Universities Space Research Association, Houston, TX, USA
Clin Biochem 42:907-10. 2009..We investigated the stability of 36 analytes related to clinical chemistry in a controlled storage study... - Body iron stores and oxidative damage in humans increased during and after a 10- to 12-day undersea diveSara R Zwart
Universities Space Research Association, Houston, TX 77058, USA
J Nutr 139:90-5. 2009..Labile plasma iron was measurable only during the dive. These data indicate that the NEEMO environment increases body iron stores and labile forms of iron, which may contribute to oxidative damage... - Nutritional status assessment before, during, and after long-duration head-down bed restSara R Zwart
Nutritional Biochemistry Laboratory, Human Adaptation and Countermeasures Division, NASA Johnson Space Center, Houston, TX 77058, USA
Aviat Space Environ Med 80:A15-22. 2009..Bed rest is a valuable ground-based model for many of the physiological changes that are associated with spaceflight. Nutritional changes during and after 60 or 90 d of head-down bed rest were evaluated... - WISE-2005: supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravityScott M Smith
Human Adaptation and Countermeasures Division, National Aeronautics and Space Administration Lyndon B Johnson Space Center, Houston, TX 77058, USA
Bone 42:572-81. 2008..The combination of resistive and aerobic exercise did not prevent bone resorption but did promote bone formation, and helped mitigate the net bone loss associated with simulated microgravity... - Nutritional status is altered in the self-neglecting elderlyScott M Smith
Nutritional Biochemistry Laboratory, Human Adaptation and Countermeasures Office, NASA Lyndon B Johnson Space Center, Houston, TX 77058, USA
J Nutr 136:2534-41. 2006..Evaluation of these data in relation to other functional and cognitive assessments are critical for evaluating the relation between nutrition and self-neglect... - Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolismSara R Zwart
Division of Space Life Sciences, Universities Space Research Association, Houston, TX, USA
J Nutr 142:427-31. 2012.... - Long-duration space flight and bed rest effects on testosterone and other steroidsScott M Smith
Space Life Sciences Directorate, Johnson Space Center, National Aeronautics and Space Administration, Enterprise Advisory Services, Inc, Houston, Texas 77058, USA
J Clin Endocrinol Metab 97:270-8. 2012..Limited data suggest that testosterone is decreased during space flight, which could contribute to bone and muscle loss... - The nutritional status of astronauts is altered after long-term space flight aboard the International Space StationScott M Smith
Human Adaptation and Countermeasures Office, NASA Lyndon B Johnson Space Center, Houston, TX 77058, USA
J Nutr 135:437-43. 2005..These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage are among critical nutritional concerns for long-duration space travelers... - Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twinsSara R Zwart
Universities Space Research Association, Houston, TX 77058, USA
Bone 40:529-37. 2007..Dietary acid load of these female subjects was significantly correlated with calcium excretion but not with other bone resorption markers... - Nutritional biochemistry of spaceflightScott M Smith
Human Adaptation and Countermeasures Division, National Aeronautics and Space Administration, Johnson Space Center, Houston, Texas 77058, USA
Adv Clin Chem 46:87-130. 2008..We review here much of what is known, and highlight areas of ongoing research and concerns for future exploration of the Moon, Mars, and beyond... - Vitamin K status in spaceflight and ground-based models of spaceflightSara R Zwart
Division of Space Life Sciences, Universities Space Research Association, Houston, TX, USA
J Bone Miner Res 26:948-54. 2011..The data presented here do not support either a need for vitamin K supplementation during spaceflight or the suggestion of using vitamin K as a bone loss countermeasure in spaceflight... - Vitamin D supplementation during Antarctic winterScott M Smith
Space Life Sciences Directorate, NASA Johnson Space Center, Houston, TX 77058, USA
Am J Clin Nutr 89:1092-8. 2009..Persons with limited exposure to ultraviolet B light, including space travelers, may not receive enough vitamin D. Recent studies indicate that optimal serum 25-hydroxyvitamin D [25(OH)D] should be > or = 80 nmol/L... - Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus ReactivationSara R Zwart
Universities Space Research Association, Houston, TX 77058, USA
J Nutr 141:692-7. 2011..The data also provide evidence that vitamin D, interacting with stress, can reduce risk of latent virus reactivation during the winter in Antarctica... - Thyroid status of Space Shuttle crewmembers: effects of iodine removalScott M Smith
Human Adaptation and Countermeasures Division, Space Medicine Division, NASA Lyndon B Johnson Space Center, Attn Mail Code SK3, 101 NASA Parkway, Houston, TX 77058, USA
Aviat Space Environ Med 82:49-51. 2011..We report here thyroid hormone data from crews flying before and after this system was implemented... - Stability of blood analytes after storage in BD SST tubes for 12 moGrace Mathew
Enterprise Advisory Services, Inc, Houston, TX, USA
Clin Biochem 42:1732-4. 2009..We studied the stability of 33 analytes related to clinical chemistry, bone, and vitamin metabolism, after storage in serum separator tubes (SST)... - Assessment of urinary N-telopeptide: point-of-care testing, sample types, and relationship to urinary helical peptide excretionSara R Zwart
Human Adaptation and Countermeasures Office, NASA Lyndon B. Johnson Space Center, Houston, TX 77058, USA
Clin Chim Acta 372:65-9. 2006..7 (17.4) and 41.5 (12.5) nmol/mmol creatinine for the POC device and ELISA]. CONCLUSIONS: Comparisons between NTX measurements from frozen and fresh samples and those analyzed by POC and ELISA techniques should be made with caution... - Nutritional status changes in humans during a 14-day saturation dive: the NASA Extreme Environment Mission Operations V projectScott M Smith
NASA Johnson Space Center, Houston, TX 77058, USA
J Nutr 134:1765-71. 2004..Together, these similarities to spaceflight provide a model to use in further defining the physiologic effects of spaceflight and investigating potential countermeasures...