Roberto Sanchez

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi The PHD finger: a versatile epigenome reader
    Roberto Sanchez
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Trends Biochem Sci 36:364-72. 2011
  2. ncbi The role of human bromodomains in chromatin biology and gene transcription
    Roberto Sanchez
    Mount Sinai School of Medicine, Department of Structural and Chemical Biology, New York, NY 10029, USA
    Curr Opin Drug Discov Devel 12:659-65. 2009
  3. ncbi Biochemical profiling of histone binding selectivity of the yeast bromodomain family
    Qiang Zhang
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e8903. 2010
  4. ncbi Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation
    Shiraz Mujtaba
    Department of Physiology and Biophysics, New York University, 1425 Madison Avenue, New York, NY 10029, USA
    Mol Cell 13:251-63. 2004
  5. ncbi EasyMIFS and SiteHound: a toolkit for the identification of ligand-binding sites in protein structures
    Dario Ghersi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Bioinformatics 25:3185-6. 2009
  6. ncbi Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures
    Dario Ghersi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Struct Funct Genomics 12:109-17. 2011
  7. ncbi Improving accuracy and efficiency of blind protein-ligand docking by focusing on predicted binding sites
    Dario Ghersi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Proteins 74:417-24. 2009
  8. ncbi Modern homology modeling of G-protein coupled receptors: which structural template to use?
    Juan Carlos Mobarec
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, NY 10029 6574, USA
    J Med Chem 52:5207-16. 2009
  9. ncbi SITEHOUND-web: a server for ligand binding site identification in protein structures
    Marylens Hernandez
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nucleic Acids Res 37:W413-6. 2009
  10. ncbi Bacillus subtilis YhcR, a high-molecular-weight, nonspecific endonuclease with a unique domain structure
    Irina A Oussenko
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    J Bacteriol 186:5376-83. 2004

Research Grants

  1. Genotype/Phenotype Correlations in Lysosomal Storage Diseases
    Roberto Sanchez; Fiscal Year: 2007
  2. High-Accuracy Modeling for Remote Homologues of Known Structures
    Roberto Sanchez; Fiscal Year: 2007
  3. High-Accuracy Modeling for Remote Homologues of Known Structures
    Roberto Sanchez; Fiscal Year: 2009

Collaborators

Detail Information

Publications16

  1. ncbi The PHD finger: a versatile epigenome reader
    Roberto Sanchez
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Trends Biochem Sci 36:364-72. 2011
    ..Moreover, they reinforce the concept that evolutionary changes in amino acids surrounding ligand binding sites on a conserved structural fold impart great functional diversity upon this family of proteins...
  2. ncbi The role of human bromodomains in chromatin biology and gene transcription
    Roberto Sanchez
    Mount Sinai School of Medicine, Department of Structural and Chemical Biology, New York, NY 10029, USA
    Curr Opin Drug Discov Devel 12:659-65. 2009
    ..These studies suggest that modulating BRD/acetyl-lysine interactions with small molecules may provide new opportunities for the control of gene expression in human health and disease...
  3. ncbi Biochemical profiling of histone binding selectivity of the yeast bromodomain family
    Qiang Zhang
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e8903. 2010
    ..Here, we report a systematic family-wide analysis of 14 yeast bromodomains binding to 32 lysine-acetylated peptides derived from known major acetylation sites in four core histones that are conserved in eukaryotes...
  4. ncbi Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation
    Shiraz Mujtaba
    Department of Physiology and Biophysics, New York University, 1425 Madison Avenue, New York, NY 10029, USA
    Mol Cell 13:251-63. 2004
    ..Using structural and biochemical analyses, we define the molecular determinants for the specificity of this molecular recognition...
  5. ncbi EasyMIFS and SiteHound: a toolkit for the identification of ligand-binding sites in protein structures
    Dario Ghersi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Bioinformatics 25:3185-6. 2009
    ..sanchezlab.org/download.html. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online...
  6. ncbi Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures
    Dario Ghersi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Struct Funct Genomics 12:109-17. 2011
    ..The advantage of energy-based approaches is emphasized, since they provide flexibility in the identification and characterization of different types of binding sites...
  7. ncbi Improving accuracy and efficiency of blind protein-ligand docking by focusing on predicted binding sites
    Dario Ghersi
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Proteins 74:417-24. 2009
    ..This is especially relevant in applications such as reverse virtual screening and structure-based functional annotation of proteins...
  8. ncbi Modern homology modeling of G-protein coupled receptors: which structural template to use?
    Juan Carlos Mobarec
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, NY 10029 6574, USA
    J Med Chem 52:5207-16. 2009
    ....
  9. ncbi SITEHOUND-web: a server for ligand binding site identification in protein structures
    Marylens Hernandez
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nucleic Acids Res 37:W413-6. 2009
    ..Various downloadable data files are also provided for offline data analysis...
  10. ncbi Bacillus subtilis YhcR, a high-molecular-weight, nonspecific endonuclease with a unique domain structure
    Irina A Oussenko
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    J Bacteriol 186:5376-83. 2004
    ..subtilis. In addition to having a unique overall domain structure, YhcR contains a hitherto unknown structural domain that we have named "NYD," for "new YhcR domain."..
  11. ncbi Systematic analysis of the effect of multiple templates on the accuracy of comparative models of protein structure
    Suvobrata Chakravarty
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    BMC Struct Biol 8:31. 2008
    ....
  12. ncbi Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IkappaBalpha kinase beta
    Juan M Carcamo
    Program in Molecular Pharmacology and Chemistry, Box 451, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell Biol 24:6645-52. 2004
    ..These findings define a function for vitamin C in signal transduction other than as an antioxidant and mechanistically illuminate how vitamin C down-modulates NF-kappaB signaling...
  13. ncbi The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment
    Taihao Jin
    Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Mol Cell 10:469-81. 2002
    ..We propose that the force produced by channel-G(beta)gamma interactions is transduced through the rigid region below the helix bundle crossing to bend TM2 at the glycine that serves as a hinge and open the gate...
  14. ncbi Structure, upstream promoter region, and functional domains of a mouse and human Mix paired-like homeobox gene
    Kenneth Sahr
    Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Gene 291:135-47. 2002
    ..These studies suggest that a number of features of paired-like protein structure and function are conserved across diverse species and provide a useful framework for studying the function and regulation of the mouse Mix gene...
  15. ncbi Systematic analysis of added-value in simple comparative models of protein structure
    Suvobrata Chakravarty
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Structure 12:1461-70. 2004
    ..This study justifies the use of models instead of the use of templates to estimate structure-derived properties of a target protein...
  16. ncbi Variable gap penalty for protein sequence-structure alignment
    M S Madhusudhan
    Department of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California at San Francisco, 94143, USA
    Protein Eng Des Sel 19:129-33. 2006
    ..We estimate that the new algorithm allows us to produce comparative models with an additional approximately 7 million accurately modeled residues in the approximately 1.1 million proteins that are detectably related to a known structure...

Research Grants5

  1. Genotype/Phenotype Correlations in Lysosomal Storage Diseases
    Roberto Sanchez; Fiscal Year: 2007
    ....
  2. High-Accuracy Modeling for Remote Homologues of Known Structures
    Roberto Sanchez; Fiscal Year: 2007
    ....
  3. High-Accuracy Modeling for Remote Homologues of Known Structures
    Roberto Sanchez; Fiscal Year: 2009
    ....