P R Hof

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism
    P R Hof
    Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029
    Neurosci Lett 139:10-4. 1992
  2. ncbi Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
    J J Radley
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 125:1-6. 2004
  3. ncbi Automated algorithms for multiscale morphometry of neuronal dendrites
    Christina M Weaver
    Department of Biomathematical Sciences and Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neural Comput 16:1353-83. 2004
  4. ncbi The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
    Thomasina L Bailey
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Siani School of Medicine, New York, NY 10029, USA
    Neurol Res 26:573-8. 2004
  5. ncbi The aging brain: morphomolecular senescence of cortical circuits
    Patrick R Hof
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Neurosci 27:607-13. 2004
  6. ncbi Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
    Andreas M Grabrucker
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, Ulm, 89081, Germany
    Mol Neurodegener 6:65. 2011
  7. ncbi Increased expression of RXR? in dementia: an early harbinger for the cholesterol dyshomeostasis?
    Afia Akram
    Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Neurodegener 5:36. 2010
  8. ncbi Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
  9. ncbi Novel cerebrovascular pathology in mice fed a high cholesterol diet
    Sonia Franciosi
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 4:42. 2009
  10. ncbi Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010

Research Grants

  1. CORE--QUANTITATIVE MORPHOLOGY
    Patrick Hof; Fiscal Year: 2007
  2. Multiscale Analysis of Neuronal Morphology
    Patrick Hof; Fiscal Year: 2009
  3. Modeling Cellular Determinants of Cognitive Decline in Aging
    Christina M Weaver; Fiscal Year: 2010

Detail Information

Publications100

  1. ncbi Distribution of neurofibrillary tangles and senile plaques in the cerebral cortex in postencephalitic parkinsonism
    P R Hof
    Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029
    Neurosci Lett 139:10-4. 1992
    ....
  2. ncbi Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
    J J Radley
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 125:1-6. 2004
    ....
  3. ncbi Automated algorithms for multiscale morphometry of neuronal dendrites
    Christina M Weaver
    Department of Biomathematical Sciences and Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neural Comput 16:1353-83. 2004
    ..g., mushroom, stubby, thin), and density distribution of spines on the branch. Results for this automated analysis are compared to published results obtained by other computer-assisted manual means...
  4. ncbi The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
    Thomasina L Bailey
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Siani School of Medicine, New York, NY 10029, USA
    Neurol Res 26:573-8. 2004
    ..Here we review neuropathological aspects of cortical microvessels in aging and AD in relationship to known cardiovascular risk factors and their possible impact on the cognitive decline seen in late-onset dementia...
  5. ncbi The aging brain: morphomolecular senescence of cortical circuits
    Patrick R Hof
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Neurosci 27:607-13. 2004
    ..Fortunately, such age-related synaptic alterations could be reversible, as suggested by recent studies of hormone replacement...
  6. ncbi Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
    Andreas M Grabrucker
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, Ulm, 89081, Germany
    Mol Neurodegener 6:65. 2011
    ..abstract:..
  7. ncbi Increased expression of RXR? in dementia: an early harbinger for the cholesterol dyshomeostasis?
    Afia Akram
    Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Neurodegener 5:36. 2010
    ..LXR/RXR functions as a sensor of cellular cholesterol concentration and mediates cholesterol efflux by inducing the transcription of key cholesterol shuffling vehicles namely, ATP-binding cassette transporter A1 (ABCA1) and ApoE...
  8. ncbi Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
    ..abstract:..
  9. ncbi Novel cerebrovascular pathology in mice fed a high cholesterol diet
    Sonia Franciosi
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 4:42. 2009
    ..abstract:..
  10. ncbi Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010
    ..abstract:..
  11. ncbi Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
    ..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions...
  12. ncbi Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates
    Monica Uddin
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit MI 48201, USA
    BMC Evol Biol 8:8. 2008
    ..Here, we test the hypothesis that COX5A, the ETC gene that encodes cytochrome c oxidase subunit 5A, shows a pattern of anthropoid-specific adaptive evolution, and investigate the distribution of this protein in catarrhine brains...
  13. ncbi Age-related changes in GluR2 and NMDAR1 glutamate receptor subunit protein immunoreactivity in corticocortically projecting neurons in macaque and patas monkeys
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, Box 1639, One Gustave L Levy Place, New York, NY 10029, USA
    Brain Res 928:175-86. 2002
    ..Also, it is apparent that age-related neuronal changes are quite subtle and involve subcellular components of the cortical circuits rather than major morphologic alterations...
  14. ncbi Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neuropathol Exp Neurol 62:55-67. 2003
    ....
  15. ncbi Structure of the cerebral cortex of the humpback whale, Megaptera novaeangliae (Cetacea, Mysticeti, Balaenopteridae)
    Patrick R Hof
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Anat Rec (Hoboken) 290:1-31. 2007
    ....
  16. ncbi An unusual population of pyramidal neurons in the anterior cingulate cortex of hominids contains the calcium-binding protein calretinin
    P R Hof
    Kastor Neurobiology of Aging Laboratories, Box 1639, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurosci Lett 307:139-42. 2001
    ....
  17. ncbi Morphomolecular neuronal phenotypes in the neocortex reflect phylogenetic relationships among certain mammalian orders
    Patrick R Hof
    Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
    Anat Rec A Discov Mol Cell Evol Biol 287:1153-63. 2005
    ....
  18. ncbi Cortical complexity in cetacean brains
    Patrick R Hof
    Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
    Anat Rec A Discov Mol Cell Evol Biol 287:1142-52. 2005
    ..In this article, we summarize data on brain size and hemisphere surface configuration in several cetacean species and present an overview of the cytoarchitectural complexity of the cerebral cortex of the bottlenose dolphin...
  19. ncbi Neurofibrillary tangles in the primary motor cortex in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Box 1639, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurosci Lett 328:294-8. 2002
    ....
  20. ncbi Life and death of neurons in the aging brain
    J H Morrison
    Neurobiology of Aging Laboratories, the Fishberg Research Center for Neurobiology, and the Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 278:412-9. 1997
    ..When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease...
  21. ncbi Differential synaptic localization of GluR2 and EAAC1 in the macaque monkey entorhinal cortex: a postembedding immunogold study
    Y He
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Neurosci Lett 311:161-4. 2001
    ..The distribution of EAAC1 may also offer protection for these neurons against excessive glutamatergic stimuli that may occur under certain pathological conditions...
  22. ncbi Interactive effects of age and estrogen on cortical neurons: implications for cognitive aging
    M E Bailey
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 191:148-58. 2011
    ..These findings have important implications for the design of hormone treatment strategies for both surgically and naturally menopausal women. This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain...
  23. ncbi AMPA GluR2 subunit is differentially distributed on GABAergic neurons and pyramidal cells in the macaque monkey visual cortex
    Y He
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 921:60-7. 2001
    ....
  24. ncbi Comparative analysis of calcium-binding protein-immunoreactive neuronal populations in the auditory and visual systems of the bottlenose dolphin (Tursiops truncatus) and the macaque monkey (Macaca fascicularis)
    I I Glezer
    Department of Cell Biology and Anatomical Sciences, CUNY Medical School Sophie Davis School of Biomedical Education, New York, NY 10031, USA
    J Chem Neuroanat 15:203-37. 1998
    ..Thus, the dominant sensory systems in both aquatic and terrestrial mammals are enriched in specific phenotypes of calcium-binding protein-immunoreactive neurons...
  25. ncbi Anatomic substrates of language: emphasizing speech
    T P Naidich
    Department of Radiology, Mt Sinai Medical Center, New York, New York 10029, USA
    Neuroimaging Clin N Am 11:305-41, ix. 2001
    ....
  26. ncbi Neurochemical and cellular specializations in the mammalian neocortex reflect phylogenetic relationships: evidence from primates, cetaceans, and artiodactyls
    P R Hof
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Behav Evol 55:300-10. 2000
    ....
  27. ncbi New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales
    S L Wearne
    Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neuroscience 136:661-80. 2005
    ....
  28. ncbi Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, and calretinin in the neocortex of mammals: phylogenetic and developmental patterns
    P R Hof
    Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Chem Neuroanat 16:77-116. 1999
    ..Our findings also support the relationships of cetaceans and ungulates, and demonstrates possible affinities between carnivores and ungulates, as well as the existence of common, probably primitive, traits in cetaceans and insectivores...
  29. ncbi Numbers of meynert and layer IVB cells in area V1: a stereologic analysis in young and aged macaque monkeys
    P R Hof
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Comp Neurol 420:113-26. 2000
    ..Rather, it is possible that more subtle alterations in the neurochemical characteristics or synaptic organization of the functional pathways subserving the different visual modalities are responsible for these deficits...
  30. ncbi Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways
    P R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 376:112-27. 1996
    ..It is possible that the preferential distribution of neurofilament protein within feedforward connections to area MT and all feedback projections is related to other distinctive properties of these corticocortical projection neurons...
  31. ncbi The motor cortex: anatomic substrates of function
    T P Naidich
    Department of Radiology and Neurosurgery, Mt Sinai Medical Center, New York, New York 10029, USA
    Neuroimaging Clin N Am 11:171-93, vii-viii. 2001
    ....
  32. ncbi Functionally relevant measures of spatial complexity in neuronal dendritic arbors
    P Rothnie
    Center for Biomathematics, Mount Sinai School of Medicine, New York, 10029-6574, USA
    J Theor Biol 238:505-26. 2006
    ....
  33. ncbi Distribution of neuronal populations containing neurofilament protein and calcium-binding proteins in the canine neocortex: regional analysis and cell typology
    P R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Chem Neuroanat 11:81-98. 1996
    ....
  34. ncbi Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways
    P R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Vision Res 37:3609-25. 1997
    ....
  35. ncbi Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery
    D S Goldwater
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroscience 164:798-808. 2009
    ....
  36. ncbi Practical approaches to stereology in the setting of aging- and disease-related brain banks
    D P Perl
    Department of Pathology Neuropathology Division, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Chem Neuroanat 20:7-19. 2000
    ....
  37. ncbi Quantitative analysis of the dendritic morphology of corticocortical projection neurons in the macaque monkey association cortex
    H Duan
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Neuroscience 114:349-59. 2002
    ..The more complex dendritic arborization of such neurons is likely linked to their participation in cortical networks that require extensive convergence of multiple afferents at the cellular level...
  38. ncbi Alterations of white matter tracts following neurotoxic hippocampal lesions in macaque monkeys: a diffusion tensor imaging study
    J L Shamy
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Hippocampus 20:906-10. 2010
    ..These findings are consistent with the notion that hippocampal damage results in altered interactions with multiple memory-related brain regions, including portions of the prefrontal cortex...
  39. ncbi Neuropathological analysis of lacunes and microvascular lesions in late-onset depression
    M Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    Neuropathol Appl Neurobiol 36:661-72. 2010
    ..More recently, we showed that thalamic and basal ganglia lacunes are associated with post-stroke depression and may affect emotional regulation. The present study examines whether this is also the case for late-onset depression...
  40. ncbi Neuronal firing sensitivity to morphologic and active membrane parameters
    Christina M Weaver
    Laboratory of Biomathematics, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Comput Biol 4:e11. 2008
    ..Our method can be adapted to analyze any computational model. Thus, sensitivity landscapes, and the quantitative predictions they provide, can give new insight into mechanisms of homeostasis in any biological system...
  41. ncbi Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging
    M M Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Am J Psychiatry 157:1994-2001. 2000
    ....
  42. ncbi Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases
    B Leveugle
    Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    Acta Neuropathol 91:566-72. 1996
    ..These results suggest that lactotransferrin may participate actively in the mechanism of neuronal degeneration in Parkinson's disease...
  43. ncbi Targeted disruption of the dopamine D(2) and D(3) receptor genes leads to different alterations in the expression of striatal calbindin-D(28k)
    M Y Jung
    Department of Psychiatry Neuroscience, Columbia University New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Neuroscience 97:495-504. 2000
    ....
  44. ncbi Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
    M E Ripps
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029
    Proc Natl Acad Sci U S A 92:689-93. 1995
    ....
  45. ncbi Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice
    E A Nimchinsky
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 416:112-25. 2000
    ..However, these patterns of cellular vulnerability may provide clues for understanding the differential susceptibility of neural structures in ALS and other neurodegenerative diseases...
  46. ncbi A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy
    Y Ma
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Neuroscience 135:1203-15. 2005
    ....
  47. ncbi Histological asymmetries of primary motor cortex predict handedness in chimpanzees (Pan troglodytes)
    Chet C Sherwood
    Department of Anthropology, The George Washington University, 2110 G Street NW, Washington, DC 20052, USA
    J Comp Neurol 503:525-37. 2007
    ..These results suggest that histological asymmetries are related to handedness in chimpanzees, while overall patterns of asymmetry at the population level might differ from humans...
  48. ncbi Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex
    Jiandong Hao
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 104:11465-70. 2007
    ..The results also suggest that the cognitive benefit of E treatment in aged monkeys is mediated by enabling synaptic plasticity through a cyclical increase in small, highly plastic dendritic spines in the primate dlPFC...
  49. ncbi Evolution of increased glia-neuron ratios in the human frontal cortex
    Chet C Sherwood
    Department of Anthropology, The George Washington University, Washington, DC 20052, USA
    Proc Natl Acad Sci U S A 103:13606-11. 2006
    ....
  50. ncbi Life and death of neurons in the aging cerebral cortex
    John H Morrison
    Department of Neuroscience, Mount Sinai School of Medicine New York, New York 10029, USA
    Int Rev Neurobiol 81:41-57. 2007
    ..This association demonstrates an important interface between reproductive and neural senescence and suggests that the synaptic alterations prevalent in normal aging may be responsive to therapy...
  51. ncbi Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 29:1296-307. 2008
    ..6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations...
  52. ncbi Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?
    Anouk Imhof
    Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:72-9. 2007
    ....
  53. ncbi Changes in the structural complexity of the aged brain
    Dara L Dickstein
    Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
    Aging Cell 6:275-84. 2007
    ..Together these multiple alterations in the brain may constitute the substrate for age-related loss of cognitive function...
  54. ncbi Differences in cortical serotonergic innervation among humans, chimpanzees, and macaque monkeys: a comparative study
    Mary Ann Raghanti
    Department of Anthropology and School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA
    Cereb Cortex 18:584-97. 2008
    ..These features may represent a greater capacity for cortical plasticity exclusive to hominoids. Taken together, these results indicate a significant reorganization of cortical serotonergic transmission in humans and chimpanzees...
  55. ncbi Temporal characteristics of tract-specific anisotropy abnormalities in schizophrenia
    David M Carpenter
    Department of Radiology ISL, Box 1234, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroreport 19:1369-72. 2008
    ..The findings suggest that there are white matter tract-specific degenerative mechanisms that may be present at the point of illness onset and may progress throughout the illness...
  56. ncbi Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients
    Joseph I Friedman
    Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Psychiatry 165:1024-32. 2008
    ....
  57. ncbi Aromatase distribution in the monkey temporal neocortex and hippocampus
    Josue G Yague
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Brain Res 1209:115-27. 2008
    ..In addition, the apparent absence of obvious differences in aromatase distribution between the two experimental groups suggests that these localization patterns are not dependent on plasma estradiol levels...
  58. ncbi Norepinephrinergic afferents and cytology of the macaque monkey midline, mediodorsal, and intralaminar thalamic nuclei
    Brent A Vogt
    Cingulum NeuroSciences Institute and SUNY Upstate Medical University, 4435 Stephanie Drive, Manlius, NY, USA
    Brain Struct Funct 212:465-79. 2008
    ..The well established role of cingulate cortex in premotor functions and the projections of Pf and other MITN to the limbic striatum suggests a specific role in mediating motor outflow for the LC-innervated nuclei of the MITN...
  59. ncbi Leftward interhemispheric asymmetry of macaque monkey temporal lobe language area homolog is evident at the cytoarchitectural, but not gross anatomic level
    Patrick J Gannon
    Academy of Medical Educators, Touro University College of Medicine, Hackensack, NJ 07601 7023, USA
    Brain Res 1199:62-73. 2008
    ..The leftward cytoarchitectural asymmetry and highly varied topography of Tpt should be factored into investigative approaches that consider this region of the cerebral cortex...
  60. ncbi The functional integration of the anterior cingulate cortex during conflict processing
    Jin Fan
    Laboratory of Neuroimaging, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 18:796-805. 2008
    ..These findings suggest that conflict processing is associated with the effective contribution of the RCZa to the neuronal activity of CCZ, as well as other cortical regions...
  61. ncbi Relative glucose metabolic rate higher in white matter in patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Radiology and Neuroscience, Mount Sinai School of Medicine, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Am J Psychiatry 164:1072-81. 2007
    ....
  62. ncbi Provisional hypotheses for the molecular genetics of cognitive development: imaging genetic pathways in the anterior cingulate cortex
    John Fossella
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, United States
    Biol Psychol 79:23-9. 2008
    ..In shaping our own imaging genetic hypotheses on the development of Attention Networks, we review relevant literature on core models of synaptic physiology and development in the anterior cingulate cortex...
  63. ncbi Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact
    Miguel A Gama Sosa
    Department of Psychiatry, Mount Sinai School of Medicine of New York University, New York, NY, USA
    Cell Res 17:619-26. 2007
    ..These apparently opposing effects could reflect differential cellular interactions needed for the proper development of the brain...
  64. ncbi Diffusion tensor anisotropy in adolescents and adults
    Jason S Schneiderman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychobiology 55:96-111. 2007
    ..Sex differences were found in the majority of areas but were most marked in the cingulum bundle and internal capsule. These results suggest continuing white matter development between adolescence and adulthood...
  65. ncbi Dendritic BC200 RNA in aging and in Alzheimer's disease
    El Mus
    The Robert F Furchgott Center for Neural and Behavioral Science, Department of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 104:10679-84. 2007
    ..Mislocalization and overexpression of BC200 RNA may be reactive-compensatory to, or causative of, synaptodendritic deterioration in AD neurons...
  66. ncbi Diffusion tensor imaging in schizophrenia
    Monte S Buchsbaum
    Neuroscience Positron Emission Tomography Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 60:1181-7. 2006
    ..Alignment of white matter axons as inferred from diffusion tensor imaging has indicated changes in schizophrenia in frontal and frontotemporal white matter...
  67. ncbi Minicolumnar abnormalities in autism
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
    Acta Neuropathol 112:287-303. 2006
    ..A reduction in both somatic and nucleolar cross sections could reflect a bias towards shorter connecting fibers, which favors local computation at the expense of inter-areal and callosal connectivity...
  68. ncbi Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys
    Huiling Duan
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 13:950-61. 2003
    ....
  69. ncbi Scaling laws in the mammalian neocortex: does form provide clues to function?
    Kimberly H Harrison
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Neurocytol 31:289-98. 2002
    ..Taken together, these approaches illustrate the benefits of a synthesis between comparative neuroanatomy and biophysics...
  70. ncbi Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus
    Diana E Moga
    Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 462:15-28. 2003
    ..Our findings suggest that the somata of these interneurons are enriched in GluR3, which may render them vulnerable to pathological states such as epilepsy and Rasmussen's encephalitis...
  71. ncbi White matter changes in schizophrenia: evidence for myelin-related dysfunction
    Kenneth L Davis
    Department of Psychiatry, Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10021, USA
    Arch Gen Psychiatry 60:443-56. 2003
    ....
  72. ncbi Hippocampal and entorhinal cortex neurofibrillary tangle formation in Guamanian Chamorros free of overt neurologic dysfunction
    Daniel P Perl
    Neuropathology Division, Department of Pathology, Mount Sinai School of Medicine, Box 1134, One Gustave L Levy Place, New York, NY 10029, USA
    J Neuropathol Exp Neurol 62:381-8. 2003
    ....
  73. ncbi Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Acta Neuropathol 106:83-8. 2003
    ..They also suggest that LB formation in limbic areas may be crucial for the development of PD dementia...
  74. ncbi Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest
    Robert E Rosenthal
    Program in Trauma, Department of Surgery, University of Maryland, Baltimore, USA
    Stroke 34:1311-6. 2003
    ....
  75. ncbi Evolution of specialized pyramidal neurons in primate visual and motor cortex
    Chet C Sherwood
    Department of Anthropology, Columbia University, New York, NY, USA
    Brain Behav Evol 61:28-44. 2003
    ..Modification of the connectional and physiological properties of these neurons could constitute an important evolutionary mode for species-specific adaptation...
  76. ncbi Induction of MC-1 immunoreactivity in axons after injection of the Fc fragment of human immunoglobulins in macaque monkeys
    Constantin Bouras
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    Acta Neuropathol 105:58-64. 2003
    ....
  77. ncbi Altered spatial arrangement of layer V pyramidal cells in the mouse brain following prenatal low-dose X-irradiation. A stereological study using a novel three-dimensional analysis method to estimate the nearest neighbor distance distributions of cells in
    Christoph Schmitz
    Department of Anatomy and Cell Biology, RWTH University of Aachen, Germany
    Cereb Cortex 12:954-60. 2002
    ..5% and a more dispersed spatial arrangement of these neurons. Considering the recent literature, it seems reasonable to consider abnormal neuronal migration as the potential basic cause of this finding...
  78. ncbi Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease
    John H Morrison
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA
    Prog Brain Res 136:467-86. 2002
    ..Thus, the aging synapse may be the key to age-related memory decline, whereas neuron death is the more prominent and problematic culprit in AD...
  79. ncbi Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neurobiol Dis 10:8-19. 2002
    ..These studies suggest that PS-1 plays a role in regulating neurogenesis in adult hippocampus and that FAD mutants may have deleterious properties independent of their effects on amyloid deposition...
  80. ncbi Cortical orofacial motor representation in Old World monkeys, great apes, and humans. I. Quantitative analysis of cytoarchitecture
    Chet C Sherwood
    Department of Anthropology, Columbia University, New York, NY, USA
    Brain Behav Evol 63:61-81. 2004
    ..These phylogenetic differences in microstructure might provide an anatomical substrate for the evolution of greater volitional fine motor control of facial expressions in great apes and humans...
  81. ncbi Cortical orofacial motor representation in Old World monkeys, great apes, and humans. II. Stereologic analysis of chemoarchitecture
    Chet C Sherwood
    Department of Anthropology, Columbia University, New York, NY, USA
    Brain Behav Evol 63:82-106. 2004
    ..These modifications might contribute to the voluntary dexterous control of orofacial muscles in great ape and human communication...
  82. ncbi Variations in the structure of the prelunate gyrus in Old World monkeys
    Estel Van der Gucht
    Laboratory of Neuroplasticity and Neuroproteomics, Katholieke Universiteit Leuven, Leuven, Belgium
    Anat Rec A Discov Mol Cell Evol Biol 288:753-75. 2006
    ..It was, however, progressively lost in most macaques, being retained only in species that diverged early in the evolution of the genus Macaca, such as M. nemestrina and M. maura...
  83. ncbi Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys
    Jiandong Hao
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 26:2571-8. 2006
    ....
  84. ncbi Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease
    Armin von Gunten
    Division of Old Age Psychiatry, Department of Psychiatry CHUV, Prilly Lausanne, Switzerland
    Brain Res Rev 51:176-211. 2006
    ....
  85. ncbi Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease
    Armin von Gunten
    Service of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland
    Neurobiol Aging 27:270-7. 2006
    ..Moreover, they show that less than 50% of the cognitive variability may be attributable to AD neuronal pathology in these areas...
  86. ncbi Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    Cathy Andorfer
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 25:5446-54. 2005
    ....
  87. ncbi Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia
    Gabriel Gold
    Department of Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 36:1184-8. 2005
    ....
  88. ncbi Is prefrontal white matter enlargement a human evolutionary specialization?
    Chet C Sherwood
    Nat Neurosci 8:537-8; author reply 538. 2005
  89. ncbi Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses
    M Mehmet Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Biol Psychiatry 57:733-42. 2005
    ....
  90. ncbi Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 field
    Armin von Gunten
    Service of Old Age Psychiatry, University of Lausanne School of Medicine, 1008 Prilly, Lausanne, Switzerland
    Exp Neurol 193:198-206. 2005
    ..They also suggest that dementia in extreme aging depends more on the damage of hippocampal subdivisions commonly less affected than on severe NFT formation and neuronal loss in the CA1 field and entorhinal cortex...
  91. ncbi Cellular and synaptic distribution of NR2A and NR2B in macaque monkey and rat hippocampus as visualized with subunit-specific monoclonal antibodies
    William G M Janssen
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 191:S28-44. 2005
    ....
  92. ncbi Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 53:1075-85. 2003
    ..The data support recent evidence that several genes encoding myelin-related proteins consistently exhibit reduced expression in schizophrenia...
  93. ncbi The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 188:224-37. 2004
    ..They also identify a new mechanism whereby PS1 FAD mutants may impair normal neuronal function and may have implications for the physiological functioning of the hippocampus in FAD...
  94. ncbi Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex
    Joseph Sebeo
    Neuropathology Division, Department of Pathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1134, New York, NY 10029, USA
    Acta Neuropathol (Berl) 107:497-503. 2004
    ..These findings demonstrate that the alpha-synuclein pathology in PDC of Guam affects not only the amygdala, but also the cerebellum, where it appears to involve both Purkinje cells and specialized astrocytes...
  95. ncbi Cortical microinfarcts and demyelination significantly affect cognition in brain aging
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 35:410-4. 2004
    ..To evaluate the cognitive consequences of such lesions, we prospectively investigated elderly individuals with various degrees of cognitive impairment but without significant neurofibrillary tangle pathology or macrovascular lesions...
  96. ncbi Morphological alterations in neurons forming corticocortical projections in the neocortex of aged Patas monkeys
    Tanya L Page
    Kastor Neurobiology of Aging Laboratories, Box 1639, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurosci Lett 317:37-41. 2002
    ....

Research Grants4

  1. CORE--QUANTITATIVE MORPHOLOGY
    Patrick Hof; Fiscal Year: 2007
    ..These MRM data will also inform the users on the degree of anatomic variation that occurs in the human amygdala...
  2. Multiscale Analysis of Neuronal Morphology
    Patrick Hof; Fiscal Year: 2009
    ..Such studies will provide crucial insight into general mechanisms of memory induction and maintenance that underlie normal cognitive function, its dysfunction in diseased states, and potential mechanisms for its restoration. ..
  3. Modeling Cellular Determinants of Cognitive Decline in Aging
    Christina M Weaver; Fiscal Year: 2010
    ....