V Haroutunian

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Increased expression of RXR? in dementia: an early harbinger for the cholesterol dyshomeostasis?
    Afia Akram
    Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Neurodegener 5:36. 2010
  2. ncbi Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease
    Yuji Kajiwara
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 5:1. 2010
  3. ncbi Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia
    Panos Roussos
    Department of Psychiatry, The Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Arch Gen Psychiatry 69:7-15. 2012
  4. ncbi Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Int J Neuropsychopharmacol 10:565-73. 2007
  5. ncbi Introduction to the special section: Myelin and oligodendrocyte abnormalities in schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Int J Neuropsychopharmacol 10:499-502. 2007
  6. ncbi Tau protein abnormalities associated with the progression of alzheimer disease type dementia
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, United States
    Neurobiol Aging 28:1-7. 2007
  7. ncbi Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 30:561-73. 2009
  8. ncbi Is there a neuropathology difference between mild cognitive impairment and dementia?
    Vahram Haroutunian
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Dialogues Clin Neurosci 11:171-9. 2009
  9. ncbi Role of the neuropathology of Alzheimer disease in dementia in the oldest-old
    Vahram Haroutunian
    James J Peters VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Neurol 65:1211-7. 2008
  10. ncbi Autism brain tissue banking
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, NY 10029 6574, USA
    Brain Pathol 17:412-21. 2007

Research Grants

  1. Contribution of cell cycle processes to myelin deficits in schizophrenia
    Vahram Haroutunian; Fiscal Year: 2010
  2. Cortico-thalamic Glutamate/GABA mRNA in schizophrenia
    Vahram Haroutunian; Fiscal Year: 2007
  3. Contribution of cell cycle processes to myelin deficits in schizophrenia
    Vahram Haroutunian; Fiscal Year: 2009

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi Increased expression of RXR? in dementia: an early harbinger for the cholesterol dyshomeostasis?
    Afia Akram
    Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Neurodegener 5:36. 2010
    ..LXR/RXR functions as a sensor of cellular cholesterol concentration and mediates cholesterol efflux by inducing the transcription of key cholesterol shuffling vehicles namely, ATP-binding cassette transporter A1 (ABCA1) and ApoE...
  2. ncbi Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease
    Yuji Kajiwara
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 5:1. 2010
    ..There is good evidence that the cytoplasmic domain of LRP1 is involved in protein-protein interactions, important in the cell biology of LRP1...
  3. ncbi Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia
    Panos Roussos
    Department of Psychiatry, The Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Arch Gen Psychiatry 69:7-15. 2012
    ....
  4. ncbi Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Int J Neuropsychopharmacol 10:565-73. 2007
    ....
  5. ncbi Introduction to the special section: Myelin and oligodendrocyte abnormalities in schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Int J Neuropsychopharmacol 10:499-502. 2007
    ....
  6. ncbi Tau protein abnormalities associated with the progression of alzheimer disease type dementia
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, United States
    Neurobiol Aging 28:1-7. 2007
    ....
  7. ncbi Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 30:561-73. 2009
    ....
  8. ncbi Is there a neuropathology difference between mild cognitive impairment and dementia?
    Vahram Haroutunian
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Dialogues Clin Neurosci 11:171-9. 2009
    ....
  9. ncbi Role of the neuropathology of Alzheimer disease in dementia in the oldest-old
    Vahram Haroutunian
    James J Peters VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Neurol 65:1211-7. 2008
    ..However, this association has not been extensively studied in the rapidly growing population of the very old...
  10. ncbi Autism brain tissue banking
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, NY 10029 6574, USA
    Brain Pathol 17:412-21. 2007
    ..Finally, we provide information on the policies and procedures that govern the distribution of brain specimens by this bank and the nature of the studies that are currently being supported directly by this program...
  11. ncbi The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, Rm 4F 33A, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Psychiatry 163:1834-7. 2006
    ..The authors sought to understand the origins of oligodendrocyte/myelin gene expression abnormalities in the brains of persons with schizophrenia...
  12. ncbi Neuropeptide abnormalities in patients with early Alzheimer disease
    K L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, and Jewish Home and Hospital, New York, NY 10029, USA
    Arch Gen Psychiatry 56:981-7. 1999
    ..To determine the relation between level of SLI and CRF-IR in different cerebrocortical regions to the earliest signs of cognitive deterioration in AD...
  13. ncbi Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 56:713-8. 1999
    ..Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression...
  14. ncbi Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 55:1185-91. 1998
    ..Do the classical neuropathological lesions of AD precede, follow, or occur in synchrony with the earliest signs of cognitive deterioration?..
  15. ncbi Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology
    M S Beeri
    Mount Sinai School of Medicine, Department of Psychiatry, One Gustave Levy Place, Box 1230, New York, NY 10029, USA
    Neurology 71:750-7. 2008
    ..To examine the association between treatment for diabetes and Alzheimer disease (AD) neuropathology...
  16. ncbi Cortical neuritic plaques and hippocampal neurofibrillary tangles are related to dementia severity in elderly schizophrenia patients
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10128, USA
    Schizophr Res 116:90-6. 2010
    ....
  17. ncbi Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and cognitive decline
    S Parvathy
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA
    Arch Neurol 58:2025-32. 2001
    ....
  18. ncbi Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
    ....
  19. ncbi N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Am J Psychiatry 158:1400-10. 2001
    ....
  20. ncbi Developmental expression profile of quaking, a candidate gene for schizophrenia, and its target genes in human prefrontal cortex and hippocampus shows regional specificity
    Tara L Lauriat
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci Res 86:785-96. 2008
    ..We also suggest that OMR transcripts might be processed by different splicing proteins in different tissues...
  21. ncbi Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease
    I Prohovnik
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Neurology 66:49-55. 2006
    ..Little is known about Alzheimer disease at advanced ages, although its incidence continues to increase at least through the ninth decade of life...
  22. ncbi Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons
    L B Hoffman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Neurology 72:1720-6. 2009
    ..To test the hypothesis that use of antihypertensive medication is associated with lower Alzheimer disease (AD) neuropathology...
  23. ncbi Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
    M S Beeri
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neurology 66:1399-404. 2006
    ..To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease...
  24. ncbi Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique
    L Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, New York, USA
    Neurosci Lett 298:191-4. 2001
    ..In contrast, we found no changes in synapsin splice variant II of the b-type isoform. Alteration of synapsin expression at the earliest clinical stage of AD may suggest novel strategies for improved treatment...
  25. ncbi Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    J Gerontol A Biol Sci Med Sci 60:471-5. 2005
    ..Future studies are encouraged to examine a variety of other characteristics such as age that may interact with diabetes affecting the incidence of AD...
  26. ncbi Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles
    G T Lesser
    Department of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, NY, USA
    Curr Alzheimer Res 8:303-12. 2011
    ..Since the associations of TC/LDL with NP were particularly stronger in ?4 carriers, varying prevalence of this allele may explain some discrepancies among prior studies...
  27. ncbi Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia
    J H Meador-Woodruff
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Arch Gen Psychiatry 54:1089-95. 1997
    ..We determined the expression of transcripts encoding the dopamine receptors in the brains of schizophrenic patients...
  28. ncbi Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions
    V Haroutunian
    Psychiatry Research, Room 3F 02, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Neurol 57:1145-50. 2000
    ..However, the degree to which the density of LBs in the brain contributes to the severity of dementia has not been clear...
  29. ncbi Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
    Schizophr Res 98:118-28. 2008
    ..All markers were differentially expressed across nuclei...
  30. ncbi Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Neurobiol Dis 21:531-40. 2006
    ..Thus, OMR gene and protein expression deficits in schizophrenia are brain-region specific, and the affected components may share regulatory elements...
  31. ncbi GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 76:581-92. 2004
    ....
  32. ncbi Variations in differential gene expression patterns across multiple brain regions in schizophrenia
    P Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6575, USA
    Schizophr Res 77:241-52. 2005
    ....
  33. ncbi Clinical, cognitive and functional characteristics of long-stay patients with schizophrenia: a comparison of VA and state hospital patients
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, 10029, New York, NY, USA
    Schizophr Res 43:3-9. 2000
    ..These data indicate that VA patients may have reduced severity of functional and cognitive impairments relative to state hospital patients, but that the relationship between the different illness variables was similar in the two groups...
  34. ncbi Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease
    L Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Box 1229, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029, USA
    Arch Neurol 58:487-92. 2001
    ..COX-2 signal was increased in all 3 regions examined among cases characterized by severe dementia. CONCLUSION: Neuronal COX-2 content in subsets of hippocampal pyramidal neurons may be an indicator of progression of dementia in early AD...
  35. ncbi mRNA expression of AMPA receptors and AMPA receptor binding proteins in the cerebral cortex of elderly schizophrenics
    Stella Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 79:868-78. 2005
    ..Small but significant differences in the amounts of GluR2, GluR3, and GRIP mRNAs were detected between the two cortical areas: more GluR3 and GRIP but less GluR2 were detected in the DLPFC than in the occipital cortex...
  36. ncbi The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 188:224-37. 2004
    ..They also identify a new mechanism whereby PS1 FAD mutants may impair normal neuronal function and may have implications for the physiological functioning of the hippocampus in FAD...
  37. ncbi Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease
    Zhong Zhao
    Neuroinflammation Research Laboratories, The Mount Sinai School of Medicine, New York, NY 10029, United States
    Neurobiol Aging 28:824-30. 2007
    ....
  38. ncbi Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mol Psychiatry 13:1001-10. 2008
    ..Thus, at least in patients with SZ or BPD, overexpression of the VSV isoform in the prefrontal cortex may represent an additional risk factor for suicidal behavior...
  39. ncbi Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton
    Tara L Lauriat
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1121:1-11. 2006
    ..Therefore, KIAA0513 is likely to be involved in signaling pathways related to these processes...
  40. ncbi Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurochem 102:1220-31. 2007
    ..ApoE protein levels in brain were, however, elevated, in LDLR-/- mice by post-transcriptional mechanisms. Collectively, these studies argue that plasma cholesterol levels do not normally regulate production of brain Abeta...
  41. ncbi Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Am J Geriatr Psychiatry 16:168-74. 2008
    ..The authors tested the hypothesis that neuritic plaques and neurofibrillary tangles are more pronounced in the brains of patients with AD with comorbid depression as compared with patients with AD without depression...
  42. ncbi Global expression-profiling studies and oligodendrocyte dysfunction in schizophrenia and bipolar disorder
    Kenneth L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 362:758. 2003
  43. ncbi Clinical dementia rating performed several years prior to death predicts regional Alzheimer's neuropathology
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dement Geriatr Cogn Disord 25:392-8. 2008
    ..To assess the relationships between early and late antemortem measures of dementia severity and Alzheimer disease (AD) neuropathology severity...
  44. ncbi Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 33:2993-3009. 2008
    ..These data suggest that the normal patterns of cell cycle gene and protein expression are disrupted in SZ and that this disruption may contribute to the oligodendroglial deficits observed in SZ...
  45. ncbi PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
    ....
  46. ncbi Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 63:161-7. 2006
    ..Although there is increasing evidence that major depression may interact with neuropathological processes in AD, there have been no studies of neuropathological changes in AD as a function of history of major depression...
  47. ncbi Altered serotonin 2C receptor RNA splicing in suicide: association with editing
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Neuroreport 19:379-82. 2008
    ..The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo...
  48. ncbi Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia
    David Kerns
    J J Peters VA Medical Center, 130 West Kingsbridge Ave, Bronx, New York, NY 10468, USA
    Schizophr Res 120:150-8. 2010
    ..These data are consistent with the hypothesis that Ol and myelin deficits in SZ involve a failure of Ol precursors to appropriately exit the cell cycle in order to differentiate and mature into myelinating Ols...
  49. ncbi Microarray database mining and cell differentiation defects in schizophrenia
    Aurelian Radu
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Adv Exp Med Biol 696:67-74. 2011
    ..These observations constitute an incentive for a new direction of study, aimed at investigating the potential role of OPCs in schizophrenia...
  50. ncbi Schizophrenia-associated reduction of neuronal and oligodendrocyte numbers in the anterior principal thalamic nucleus
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, NY 10467, USA
    Schizophr Res 85:245-53. 2006
    ..These findings are consistent with a previous report of reduced neuronal number in the anterior principal nucleus of male SZs and add to a growing body of evidence implicating oligodendrocyte abnormalities in SZ...
  51. ncbi Cross-domain variability of cognitive performance in very old nursing home residents and community dwellers: relationship to functional status
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Gerontology 51:206-12. 2005
    ..Recent evidence suggests that cross-domain variability in cognition may be related to subsequent cognitive decline beyond mean performance levels in cognitive tasks...
  52. ncbi Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1318:167-77. 2010
    ....
  53. ncbi Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals
    Pavel Katsel
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 4:e7642. 2009
    ..We sought to characterize transcriptional and protein profiles of dementia in the oldest-old...
  54. ncbi Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer disease
    Michael Serby
    Departments of Psychiatry and Psychology, Mount Sinai School of Medicine, New York, NY, USA
    Am J Geriatr Psychiatry 11:371-4. 2003
    ..CONCLUSION: The co-occurrence of AD and LB pathology is associated with higher numbers of LBs and more severe dementia than when classical AD or LB lesions occur alone...
  55. ncbi RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    J Neurochem 87:1402-12. 2003
    ..Quantitation of 5-HT2CR and 5-HT2CR-tr mRNA variants revealed that the expression of 5-HT2CR-tr was approximately 50% of that observed for the full-length isoform...
  56. ncbi Neuropsychological differences between late-onset and recurrent geriatric major depression
    Michael A Rapp
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, Box 1230, New York, NY 10029, USA
    Am J Psychiatry 162:691-8. 2005
    ..The purpose of this study was to explore differences in neuropsychological function, symptoms, and cardiovascular comorbidity between patients with late-onset and recurrent geriatric major depression...
  57. ncbi The MMSE orientation for time domain is a strong predictor of subsequent cognitive decline in the elderly
    Elizabeth Guerrero-Berroa
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Int J Geriatr Psychiatry 24:1429-37. 2009
    ..However, little is known about the relationship of performance in specific cognitive domains to subsequent overall decline...
  58. ncbi Relationship of neuropsychological performance to functional status in nursing home residents and community-dwelling older adults
    Michael A Rapp
    Dept of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, Box 1240, New York, NY 10029 6574, USA
    Am J Geriatr Psychiatry 13:450-9. 2005
    ..The authors examined the association between neuropsychological tests of executive functioning and episodic memory and functional disability in nursing home residents versus community-dwelling older adults...
  59. ncbi Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029 6575, USA
    Schizophr Res 79:157-73. 2005
    ....
  60. ncbi White matter changes in schizophrenia: evidence for myelin-related dysfunction
    Kenneth L Davis
    Department of Psychiatry, Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10021, USA
    Arch Gen Psychiatry 60:443-56. 2003
    ....
  61. ncbi Number of children is associated with neuropathology of Alzheimer's disease in women
    Michal Schnaider Beeri
    The Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    Neurobiol Aging 30:1184-91. 2009
    ..To examine the association between number of born children and neuropathology of Alzheimer's disease (AD)...
  62. ncbi The effects of cardiovascular risk factors on cognitive compromise
    Michal Schnaider Beeri
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Dialogues Clin Neurosci 11:201-12. 2009
    ..This may be crucial for understanding the effects on cognition of drugs and other approaches, such as lifestyle change, for treating these risk factors...
  63. ncbi Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Neurochem Res 32:845-56. 2007
    ..This disrupted balance within the sphingolipid metabolism may trigger signaling events promoting neurodegeneration across cortical regions. This potential mechanism may provide a link between lipid metabolism disturbance and AD...
  64. ncbi Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats
    V Haroutunian
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029
    Brain Res 507:261-6. 1990
    ..These results suggest that combined cholinergic/noradrenergic therapy may be of value in the treatment of some Alzheimer's disease patients...
  65. ncbi Age-dependent spatial memory deficits in transgenic mice expressing the human mid-sized neurofilament gene: I
    V Haroutunian
    Psychiatry Service, Bronx VA Medical Center, NY 10468, USA
    Brain Res Mol Brain Res 42:62-70. 1996
    ..Whether NF-M transgenic mice exhibit even more severe behavioral impairments when they become aged is currently under study...
  66. ncbi Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 53:1075-85. 2003
    ..The data support recent evidence that several genes encoding myelin-related proteins consistently exhibit reduced expression in schizophrenia...
  67. ncbi Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia
    William Byne
    Department of Psychiatry and Pathology, Mount Sinai School of Medicine, New York, USA
    Am J Psychiatry 159:59-65. 2002
    ..The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus...
  68. ncbi Altered Abeta formation and long-term potentiation in a calsenilin knock-out
    Christina Lilliehook
    Laboratory of Molecular Neuropsychiatry and Department of Psychiatry, Mount Sinai School of Medicine of New York University, New York, New York 10029, USA
    J Neurosci 23:9097-106. 2003
    ..The data presented here show that lack of calsenilin affects both Abeta formation and the A-type current. We suggest that these effects are separate events, caused by a common mechanism possibly involving protein transport...
  69. ncbi Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients
    Martin R Gluck
    Departmnent of Neurology, Medical Research Building, Bronx Veterans Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 159:1165-73. 2002
    ....
  70. ncbi Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Brain Res 1214:23-34. 2008
    ..These results provide detailed and quantitative information on iGluR subunit expression in multiple nuclei of the human thalamus but suggest that alterations in their expression are not a prominent feature of schizophrenia...
  71. ncbi Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 29:1296-307. 2008
    ..6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations...
  72. ncbi Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophrenia
    Sarah M Clinton
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Neurochem 98:1114-25. 2006
    ..Further, these findings provide additional evidence of NMDA receptor alterations in schizophrenia, which may play an important role in the neurobiology of the illness...
  73. ncbi Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain
    T L Lauriat
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1229, New York, NY 10029, USA
    Neuroscience 137:843-51. 2006
    ..However, because most of the schizophrenic subjects in the cohort had been treated with antipsychotics for many years, it is still possible that changes in transporter expression were masked by medication effects...
  74. ncbi Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice
    S Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 905:142-51. 2001
    ....
  75. ncbi Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia
    C Schmauss
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029
    Proc Natl Acad Sci U S A 90:8942-6. 1993
    ..Many variables associated with either the course and/or the therapeutic management of the disease may account for the selective loss of D3 mRNA in the motor, somatosensory, and somatosensory association areas of schizophrenic brains...
  76. ncbi FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
    Yuji Kajiwara
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY, USA
    PLoS ONE 4:e5071. 2009
    ..As caspase-4 shows evidence of being a primate-specific gene, current models of AD and other neurodegenerative conditions may be incomplete because of the absence of this gene in the murine genome...
  77. ncbi Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia
    Zhongmin Xiang
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, 10029-6574, USA
    Dis Markers 22:95-102. 2006
    ..These results suggest that microglia activation increases with the progression of AD, with the increase varying depending on the involved brain region...
  78. ncbi Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York, NY 10468, USA
    Schizophr Res 84:1-14. 2006
    ..Our studies suggest that aberrant IR function may be important in the pathophysiology of schizophrenia...
  79. ncbi Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype
    Mirsada Causevic
    Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neuropathol Exp Neurol 62:999-1005. 2003
    ..We found no correlation between LRP levels and either presence of the disease or cognitive decline. In addition, we found no correlation between the LRP exon 3 polymorphism and either AD or LRP levels...
  80. ncbi Mitochondrial enzymes in schizophrenia
    Parvesh Bubber
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, NY, 10605, USA
    J Mol Neurosci 24:315-21. 2004
    ..However, in schizophrenia, unlike a number of neurodegenerative diseases, reductions in the activities of the key mitochondrial enzymes KGDHC and PDHC are not frequent...
  81. ncbi Increased locomotor activity in mice lacking the low-density lipoprotein receptor
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Behav Brain Res 191:256-65. 2008
    ..Collectively these studies suggest that while LDLR-/- mice exhibit no major developmental defects, LDLR nevertheless plays a significant role in modulating locomotor behavior in the adult...
  82. ncbi Serum lipids are related to Alzheimer's pathology in nursing home residents
    Gerson T Lesser
    Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, N Y, USA
    Dement Geriatr Cogn Disord 27:42-9. 2009
    ..Studies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias...
  83. ncbi Parkinson's disease dementia: a diminished role for the Lewy body
    Leslie S Libow
    The Jewish Home and Hospital Lifecare System, New York, NY 10025, USA
    Parkinsonism Relat Disord 15:572-5. 2009
    ..More research with a larger sample size is needed to determine whether the LB may be a secondary phenomenon and/or an "innocent-bystander". The entire role of the LB in PD dementia is again brought into question...
  84. ncbi Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia
    Patrick R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurochem Res 27:1193-200. 2002
    ..Therapies modulating oligodendrocyte survival and differentiation may therefore be beneficial in schizophrenia...
  85. ncbi Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice
    S Dracheva
    Dr Arthur M Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 157:169-79. 1999
    ..These studies demonstrate that altering the levels of D1 receptor expression reverses the effects of D1 agonism on locomotor initiation and rearing...
  86. ncbi Issues and perspectives on brain tissue banking
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
    Curr Psychiatry Rep 4:233-4. 2002
  87. ncbi Amyloid beta pathology in Alzheimer's disease and schizophrenia
    Dorota Religa
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institutet, 141 86 Huddinge, Sweden
    Am J Psychiatry 160:867-72. 2003
    ..Biochemical and genetic studies suggest that amyloid beta-peptide is central in Alzheimer's disease. The authors examined the possible involvement of amyloid beta-peptide in cognitive impairment in schizophrenia...
  88. ncbi Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia
    Oxana O Polesskaya
    Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci Res 74:111-22. 2003
    ..These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors...
  89. ncbi Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia
    Sarah M Clinton
    Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
    Am J Psychiatry 160:1100-9. 2003
    ..They hypothesized that this reduction is associated with specific NR(1) isoforms and that NMDA receptor-related postsynaptic density proteins are abnormally expressed...
  90. ncbi Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia
    Akin Oni-Orisan
    Wayne State University School of Medicine, Detroit, Michigan, USA
    Biol Psychiatry 63:766-75. 2008
    ..Recent studies have shown that VGLUTs regulate synaptic activity via the amount of glutamate released. Accordingly, we hypothesized that VGLUTs are altered in schizophrenia, contributing to dysfunction of presynaptic activity...
  91. ncbi Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's disease
    Pavel L Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine New York, New York 10029 USA
    Int Rev Neurobiol 63:41-82. 2005
  92. ncbi CCR1 is an early and specific marker of Alzheimer's disease
    Meredith Halks-Miller
    Pharmacopathology, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
    Ann Neurol 54:638-46. 2003
    ..Thus, neuronal CCR1 is not a generalized marker of neurodegeneration. Rather, it appears to be part of the neuroimmune response to Abeta42-positive neuritic plaques...
  93. ncbi Serine racemase protein expression in cortex and hippocampus in schizophrenia
    Amy E Steffek
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Neuroreport 17:1181-5. 2006
    ....
  94. ncbi Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  95. ncbi Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Schizophr Res 90:15-27. 2007
    ..Our results support the hypothesis that myelination and oligodendrocyte function are impaired in schizophrenia...
  96. ncbi Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex
    Karen L Baracskay
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Synapse 60:271-9. 2006
    ..These alterations in spinophilin and calcyon mRNA levels in schizophrenic prefrontal and cingulate cortex provide further evidence of altered dopaminergic neurotransmission in this illness...
  97. ncbi Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia
    Timothy R Peirce
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, Wales
    Arch Gen Psychiatry 63:18-24. 2006
    ..However, it is unclear whether the observed changes in the schizophrenic brain are primary or secondary...
  98. ncbi 82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease
    Sandeep K Gill
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ont, Canada
    Neurobiol Aging 28:1028-40. 2007
    ....
  99. ncbi Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
    Daya S Gupta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
    Synapse 57:123-31. 2005
    ....
  100. ncbi Mitochondrial abnormalities in Alzheimer brain: mechanistic implications
    Parvesh Bubber
    Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, NY 10605, USA
    Ann Neurol 57:695-703. 2005
    ..01), suggesting a coordinated mitochondrial alteration. The highest correlation was with pyruvate dehydrogenase complex (r = 0.77, r2= 0.59). Measures to improve TCA cycle metabolism might benefit AD patients...
  101. ncbi Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia
    Emile G Bruneau
    Mental Health Research Institute and Department of Psychiatry, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Schizophr Res 75:27-34. 2005
    ..Increased PAG and GS transcripts suggest enhanced glutamatergic neurotransmission in the thalamus and its efferent targets in schizophrenia...

Research Grants12

  1. Contribution of cell cycle processes to myelin deficits in schizophrenia
    Vahram Haroutunian; Fiscal Year: 2010
    ..We predict that the identification of the specific cell types and biological processes affected by the disease will enable the design and development of rational and evidence based therapeutic approaches. ..
  2. Cortico-thalamic Glutamate/GABA mRNA in schizophrenia
    Vahram Haroutunian; Fiscal Year: 2007
    ..In addition, studies in rats will test the hypothesis that the glutamatergic and GABAergic abnormalities in the prefrontal cortex are a direct result of lesions in the MDN. ..
  3. Contribution of cell cycle processes to myelin deficits in schizophrenia
    Vahram Haroutunian; Fiscal Year: 2009
    ..The current proposal aims to address both these questions using an animal model system. ..