Research Topics
| Alec J DavidsonSummaryAffiliation: Morehouse School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Resetting of central and peripheral circadian oscillators in aged ratsAlec J Davidson
Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
Neurobiol Aging 29:471-7. 2008..The consequences of these deficits are unknown, but may contribute to organ and brain diseases in the aged as well as the health problems that are common in older shift-workers...- Lesion studies targeting food-anticipatory activityAlec J Davidson
Circadian Rhythms and Sleep Disorders Program, Department of Neurobiology, Morehouse School of Medicine, 720 Westview Dr, SW, Atlanta, GA 30310, USA
Eur J Neurosci 30:1658-64. 2009..The site of the feeding-entrainable circadian pacemaker, if it resides in a discrete structure at all, remains unknown... - Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing systemAlec J Davidson
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
Eur J Neurosci 29:171-80. 2009..Full resynchronization of the SCN and peripheral timing system, as measured by a circadian reporter gene, did not occur until after 8 days in the advanced light cycle... - Localization of a circadian clock in mammalian photoreceptorsGianluca Tosini
Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
FASEB J 21:3866-71. 2007..These results demonstrate that mammalian photoreceptors contain the circadian pacemaker driving rhythmic melatonin synthesis... - Dysregulation of inflammatory responses by chronic circadian disruptionOscar Castanon-Cervantes
Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
J Immunol 185:5796-805. 2010..Such immune changes might be a common mechanism for the myriad negative health effects of shift work... - Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillatorsNina Vujovic
Department of Biology, University of Virginia, Charlottesville, Virginia, USA
Am J Physiol Regul Integr Comp Physiol 295:R355-60. 2008..Arrhythmicity may result if one signal is not clearly dominant. Elimination of the dominant signal (e.g., surgical sympathectomy) may allow a secondary signal to control phase... - Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liverAlec J Davidson
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
Int J Cancer 118:1623-7. 2006..Specifically, meal and treatment schedules could be designed that take advantage of coincident times of greatest tumor sensitivity and lowest sensitivity of host tissue to damage... - Intrinsic regulation of spatiotemporal organization within the suprachiasmatic nucleusJennifer A Evans
Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 6:e15869. 2011..The consistency of SCN spatiotemporal organization across individuals and across planes of section suggests that the precise phasing of oscillators is a robust feature of the pacemaker important for its function... - Daily oscillations in liver function: diurnal vs circadian rhythmicityAlec J Davidson
Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
Liver Int 24:179-86. 2004..Rather, these clocks are largely responsive to stimuli involved in nutrient intake. The interaction between these two systems may be very important for the ability of organisms to synchronize their internal physiology... - SCN: ringmaster of the circadian circus or conductor of the circadian orchestra?Alec J Davidson
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
Novartis Found Symp 253:110-21; discussion 121-5, 281-4. 2003..We have tried to make some of the issues concerning the role of the SCN within the entire system more explicit using the somewhat fanciful metaphor referred to in the title... - Birds of a feather clock together--sometimes: social synchronization of circadian rhythmsAlec J Davidson
Department of Biology, University of Virginia, Charlottesville, VA 22904-4328, USA
Curr Opin Neurobiol 13:765-9. 2003..Social influences on circadian timing might function to tightly organize the social group, thereby decreasing the chances of predation and increasing the likelihood of mating... - Food-anticipatory activity and liver per1-luc activity in diabetic transgenic ratsAlec J Davidson
U VA, Charlottesville
Physiol Behav 76:21-6. 2002..In two separate experiments, FAA emerged and liver Per1 phase-shifted in response to daytime 8-h food restriction. The results rule out insulin as a necessary component of this system... - Search for the feeding-entrainable circadian oscillator: a complex propositionAlec J Davidson
Am J Physiol Regul Integr Comp Physiol 290:R1524-6. 2006
Research Grants
- Circadian organization in the aged rodentAlec Davidson; Fiscal Year: 2004....
- Nutritional manipulation of circadian rhythms and cancerAlec Davidson; Fiscal Year: 2007..The experiments will form the basis for future study of circadian and nutritional influences on development of this and other cancers. ..