Paul M Wise

..In short: (i). the method developed here provides a temporally fine-grained tool to study the time-course of nasal irritation, and (ii). nasal irritation from carbon dioxide shows relatively rapid temporal dynamics...

..Thus, the current experiments used an objective measure of sensitivity to chemical irritation in the nose to test the hypothesis that menthol vapor modulates sensitivity to chemical irritation in the airways...

..These types of context effects are relevant to the study of taste-taste mixture interactions and should provide insight into the perceptual similarities among the taste qualities...

..The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well...

..Current studies use a structure-activity approach to determine how molecular parameters correlate with how well a compound integrates over time...

..Further, preliminary analyses suggest that, for data pooled across both chemical series, n varies systematically with molecular parameters related to solubility and diffusion...

..Thus, the prevalence and demographics of trimethylaminuria remain unclear...

..This result suggests that environment plays a larger role than genetics in determining individual differences in recognition thresholds for saltiness...

..That just one molecular parameter can help predict degree of integration suggests that a structure-activity approach to understanding temporal integration shows promise...

..These results suggest that interaction among odors in binary mixtures does depend on structural similarity, at least for detection of carboxylic acids. Future studies can determine if this result is particular to carboxylic acids...

..These results suggest that an imperfect, mass-integrator model can describe short-term integration of nasal lateralization of ethanol...

..These results suggest that an imperfect mass-integrator model may be able to describe short-term integration of nasal irritation from ammonia at both the threshold and supra-threshold levels...

..Thus, for carbon dioxide, the nasal trigeminal system functions as an imperfect integrator at threshold-level...

..Thus, carbon-chain length appears to influence not only summation with other carboxylic acids but also summation with at least some unrelated compounds...

..In the present case, a cut-off of chemesthetic potency occurred between butyl butyrate and hexyl butyrate for the group of subjects, with some variation of the boundary among individuals...

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..The three experiments will lay groundwork for a psychophysics of dynamics that can help physiologists understand underlying mechanisms and policy-makers predict how our dynamic sensory systems will react over time. ..