Research Topics
| J M DeSessoSummaryAffiliation: Mitretek Healthcare Country: USA Publications
| Collaborators |
Detail Information
Publications
An assessment of the developmental toxicity of inorganic arsenicJ M DeSesso
Mitretek Systems, Inc, McLean, Virginia 22102, USA
Reprod Toxicol 12:385-433. 1998..It is concluded that under environmentally relevant exposure scenarios (e.g., 100 ppm in soil), inorganic arsenic is unlikely to pose a risk to pregnant women and their offspring...- Apparent lability of neural tube closure in laboratory animals and humansJ M DeSesso
Biomedical Research Institute, Mitretek Systems, McLean, Virginia 22102, USA
Am J Med Genet 87:143-62. 1999..We further conclude that, because of both the relatively high prevalence and the multifactorial nature of NTDs, the mere occurrence of an NTD is insufficient for inferring that the defect was caused by an exogenous agent... - Hydroxylamine moiety of developmental toxicants is associated with early cell death: a structure-activity analysisJ M DeSesso
Mitretek Systems, McLean, Virginia 22102, USA
Teratology 62:346-55. 2000..Several chemicals that are structurally related to hydroxyurea, and that possess a terminal hydroxylamine moiety (-NHOH), also produce limb abnormalities... - Assessment of the carcinogenicity associated with oral exposures to hydrogen peroxideJ M DeSesso
Mitretek Systems, McLean, Virginia, USA
Food Chem Toxicol 38:1021-41. 2000..In-depth analysis of the available data supports the conclusion that oral ingestion of H(2)O(2) should not be considered a carcinogenic threat... - Anatomical and physiological parameters affecting gastrointestinal absorption in humans and ratsJ M DeSesso
Mitretek Systems, VA 22102, McLean, USA
Food Chem Toxicol 39:209-28. 2001..Taken together, these differences may be of sufficient magnitude to alter the assessment of risks/benefits for a given compound when those risks/benefits are based on interspecies extrapolations... - Teratogen update: inorganic arsenicJ M DeSesso
Biomedical Research Institute, Mitretek Systems, McLean, Virginia 22102, USA
Teratology 64:170-3. 2001..These studies, which used predominantly injection exposures, coupled with the paucity of epidemiology data, resulted in the erroneous inference that inorganic arsenic should be considered a human teratogen... - The case for integrating low dose, beneficial responses into US EPA risk assessmentsJ M DeSesso
Mitretek Systems, 3150 Fairview Park Drive, Falls Church, VA 22042, USA
Hum Exp Toxicol 25:7-10. 2006..However, when such data are not readily available, as is likely the case when the mechanism of action of the benefit differs from that of toxicity, current US EPA methods appear adequate... - Lectin teratogenesis. II: Demonstration of increased binding of concanavalin A to limb buds of rabbit embryos during the teratogenically sensitive periodJ M DeSesso
Chemical and Biological Systems, Civil Systems Division, MITRE Corporation, McLean, Virginia 22102
Teratology 39:395-407. 1989.... - Ethoxyquin and nordihydroguaiaretic acid reduce hydroxyurea developmental toxicityJ M DeSesso
Toxic and Hazardous Materials Assessment and Control, Civil Systems Division, MITRE Corporation, McLean, Virginia 22102
Reprod Toxicol 4:267-75. 1990..The results suggest that the antioxidant properties of these substances interfere with the rapidly occurring toxic effects of HU and that this may account for amelioration of HU developmental toxicity...