Research Topics
| Steven W TaylorSummaryAffiliation: MitoKor Inc Country: USA Publications
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Detail Information
Publications
An alternative strategy to determine the mitochondrial proteome using sucrose gradient fractionation and 1D PAGE on highly purified human heart mitochondriaSteven W Taylor
MitoKor, 11494 Sorrento Valley Road, San Diego California 92121, USA
J Proteome Res 1:451-8. 2002..The technique described here should also be useful for the identification of new protein-protein associations as exemplified by the validation of a recently discovered complex that involves proteins belonging to the prohibitin family...- Oxidative post-translational modification of tryptophan residues in cardiac mitochondrial proteinsSteven W Taylor
MitoKor, San Diego, California 92121, USA
J Biol Chem 278:19587-90. 2003.... - Chemoenzymatic synthesis of peptidyl 3,4-dihydroxyphenylalanine for structure-activity relationships in marine invertebrate polypeptidesSteven W Taylor
Center for Marine Biotechnology and Biomedicine, University of California, San Diego, La Jolla, California, 92093 0204, USA
Anal Biochem 302:70-4. 2002.... - Global organellar proteomicsSteven W Taylor
MitoKor, 11494 Sorrento Valley Rd, San Diego, CA 92121, USA
Trends Biotechnol 21:82-8. 2003..We assess the relative merits of the different methods used and discuss issues and future directions in the field... - Characterization of the human heart mitochondrial proteomeSteven W Taylor
MitoKor, 11494 Sorrento Valley Road, San Diego, California 92121, USA
Nat Biotechnol 21:281-6. 2003..The biochemical roles of 19% of the identified proteins have not been defined. This database of proteins provides a comprehensive resource for the discovery of novel mitochondrial functions and pathways... - A sulfated, phosphorylated 7 kDa secreted peptide characterized by direct analysis of cell culture mediaSteven W Taylor
Amylin Pharmaceuticals, Inc, 9360 Towne Centre Drive, San Diego, California 92121, USA
J Proteome Res 7:795-802. 2008..The sulfation site was not previously described nor predicted by informatic analysis of the peptide's precursor sequence... - Identification of protein associations in organelles, using mass spectrometry-based proteomicsDale E Warnock
MitoKor, Inc, 11494 Sorrento Valley Road, San Diego, California 92121, USA
Mass Spectrom Rev 23:259-80. 2004..Those developments demonstrate that a revolution in cellular biology, fueled by technical advances in MS-based proteomic techniques, is well underway... - Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytesJ Andy Tincu
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Biol Chem 278:13546-53. 2003..The small size, rapid action, and potent anti-staphylococcal activity of plicatamide and PL-101 make them intriguing subjects for future antimicrobial peptide design... - Fragmentation of tunichrome Sp-1 is dominated by an unusual gas-phase intramolecular rearrangementSteven W Taylor
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
J Mass Spectrom 38:1105-9. 2003..This rearrangement was not observed for peptide analogs of tunichrome Sp-1 that did not contain the dcDeltaDOPA at the C-terminus, confirming that the presence of dcDeltaDOPA is critical for the rearrangement... - A primary colonic crypt model enriched in enteroendocrine cells facilitates a peptidomic survey of regulated hormone secretionSvetlana E Nikoulina
Amylin Pharmaceuticals, Inc, San Diego, California 92121, USA
Mol Cell Proteomics 9:728-41. 2010..This work represents the first step in characterizing physiologically relevant peptidomic secretion of gastrointestinally derived primary cells and will aid in elucidating new endocrine function... - Efficient high-throughput discovery of large peptidic hormones and biomarkersSteven W Taylor
Amylin Pharmaceuticals, Inc, 9360 Towne Centre Dr, San Diego California 92121, USA
J Proteome Res 5:1776-84. 2006..The approach demonstrates high efficiency pattern-based recognition analysis of complex neuroendocrine peptide sets and enables rapid identification of biomarkers from biological material... - Antimicrobial peptides from marine invertebratesJ Andy Tincu
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, 8602 La Jolla Shores Dr, MC 0204, San Diego, La Jolla, CA 92093-0204
Antimicrob Agents Chemother 48:3645-54. 2004 - Tunichrome sp-1: new pentapeptide tunichrome from the hemocytes of Styela plicataJ Andy Tincu
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Nat Prod 65:377-8. 2002..The peptide L-DOPA-L-DOPA-Gly-L-Pro-dcdeltaDOPA (where DOPA = 3,4-dihydroxyphenylalanine and dcdeltaDOPA = decarboxy-(E)-alpha,beta-dehydro-3,4-dihydroxyphenylalanine) we designate as tunichrome Sp-1... - Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bassXavier Lauth
Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California 92093-0830, USA
J Biol Chem 277:5030-9. 2002..Thus, moronecidin is a new alpha-helical, broad spectrum antimicrobial peptide isolated from the skin and gills of hybrid striped bass... - The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurificationJames Murray
Department of Molecular Biology, University of Oregon, Eugene 97403, USA
J Biol Chem 278:13619-22. 2003..The concordance of data from human and bovine complex I isolated by different procedures adds to the certainty that these novel proteins of seemingly diverse function are a part of complex I... - Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometrySara P Gaucher
Buck Institute for Age Research, Novato, California 94945, USA
J Proteome Res 3:495-505. 2004..Nat. Biotechnol. 2003, 21, 281-286). We now report two subsequent studies where multidimensional liquid chromatography MS/MS was investigated as an alternative means for characterizing the same sample... - Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometryJames Murray
Department of Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA
J Biol Chem 278:37223-30. 2003..W., Fahy, E., Murray, J., Capaldi, R. A., and Ghosh, S. S. (2003) J. Biol. Chem. 278, 19587-19590). These sites of oxidation and nitration may be useful biomarkers for assessing oxidative stress in neurodegenerative disorders... - A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studiesRobert Aggeler
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
J Biol Chem 277:33906-12. 2002..The system is therefore suitable to screen patient-derived samples for alterations in amount or functionality of both the F(1)F(0) ATPase and IF(1)...