WALTER PROZIALECK

Summary

Affiliation: Midwestern University
Country: USA

Publications

  1. ncbi Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555, Downers Grove, IL 60515, USA
    Toxicol In Vitro 20:942-53. 2006
  2. ncbi A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer
    Joshua R Edwards
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    BMC Physiol 7:1. 2007
  3. ncbi Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
    A M Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 1:7. 2001
  4. ncbi Cell adhesion molecules in chemically-induced renal injury
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States
    Pharmacol Ther 114:74-93. 2007
  5. ncbi Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity
    W C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, Illinois 60515, USA
    Kidney Int 72:985-93. 2007
  6. ncbi The vascular system as a target of metal toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, Illinois 60515, USA
    Toxicol Sci 102:207-18. 2008
  7. ncbi The vascular endothelium as a target of cadmium toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States
    Life Sci 79:1493-506. 2006
  8. ncbi Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA
    BMC Physiol 4:10. 2004
  9. ncbi Interaction of cadmium (Cd(2+)) with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin
    W C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Biochim Biophys Acta 1451:93-100. 1999
  10. ncbi Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA
    Toxicol Appl Pharmacol 238:306-14. 2009

Research Grants

  1. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2001
  2. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007

Detail Information

Publications25

  1. ncbi Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555, Downers Grove, IL 60515, USA
    Toxicol In Vitro 20:942-53. 2006
    ....
  2. ncbi A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer
    Joshua R Edwards
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    BMC Physiol 7:1. 2007
    ..Total cell number was determined from the DAPI staining in random microscopic fields and the number of necrotic cells in the same field was determined by ethidium homodimer labeling...
  3. ncbi Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
    A M Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 1:7. 2001
    ....
  4. ncbi Cell adhesion molecules in chemically-induced renal injury
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States
    Pharmacol Ther 114:74-93. 2007
    ..This review also includes a discussion of the various mechanisms, by which these substances can affect cell adhesion molecules in the kidney...
  5. ncbi Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity
    W C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, Illinois 60515, USA
    Kidney Int 72:985-93. 2007
    ..Immunohistochemical analysis showed that Kim-1 was present in proximal tubule cells of the Cd-treated rats. Our results suggest that Kim-1 may be a useful biomarker of early stages of Cd-induced proximal tubule injury...
  6. ncbi The vascular system as a target of metal toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, Illinois 60515, USA
    Toxicol Sci 102:207-18. 2008
    ....
  7. ncbi The vascular endothelium as a target of cadmium toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States
    Life Sci 79:1493-506. 2006
    ..In addition the possible roles of the vascular endothelium in mediating the tumor promoting and anticarcinogenic effects of Cd are discussed...
  8. ncbi Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA
    BMC Physiol 4:10. 2004
    ....
  9. ncbi Interaction of cadmium (Cd(2+)) with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin
    W C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Biochim Biophys Acta 1451:93-100. 1999
    ..These findings are consistent with the hypothesis that E-cadherin may be a direct molecular target for Cd(2+) toxicity...
  10. ncbi Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA
    Toxicol Appl Pharmacol 238:306-14. 2009
    ..These results indicate that the Cd-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule...
  11. ncbi Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Toxicol Appl Pharmacol 189:180-95. 2003
    ..These results indicate that Cd can disrupt cadherin-dependent cell-cell junctions in the proximal tubule, and they raise the possibility that a loss of cadherin-mediated adhesion may contribute to the nephrotoxic effects of Cd...
  12. ncbi Preclinical evaluation of novel urinary biomarkers of cadmium nephrotoxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA
    Toxicol Appl Pharmacol 238:301-5. 2009
    ..These results provide additional evidence that Kim-1 is a sensitive biomarker of the early stages of Cd-induced proximal tubule injury...
  13. ncbi Cadherins and NCAM as potential targets in metal toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, Illinois 60515, USA
    Toxicol Appl Pharmacol 182:255-65. 2002
    ..These studies have provided important new insights into the molecular mechanisms of metal toxicity and have opened several exciting avenues of research...
  14. ncbi Early biomarkers of cadmium exposure and nephrotoxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA
    Biometals 23:793-809. 2010
    ..In addition, several novel biomarkers (kidney injury molecule-1, ?-glutathione-S-transferase and insulin) that offer the potential for improved biomonitoring of Cd-exposed populations are discussed...
  15. ncbi Effects of acute and 2-day genistein treatment on cardiac function and ischemic tolerance in ovariectomized rats
    Layla Al-Nakkash
    Department of Physiology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona 85308, USA
    Gend Med 6:488-97. 2009
    ..Genistein, a naturally occurring isoflavonic phytoestrogen associated with reduced incidence of heart disease, may be a possible alternative treatment for postmenopausal women with heart disease...
  16. ncbi Cadmium, diabetes and chronic kidney disease
    Joshua R Edwards
    Department of Pharmacology, Midwestern University, Downers Grove, IL 60515, USA
    Toxicol Appl Pharmacol 238:289-93. 2009
    ..Together, these findings indicate that Cd may be a factor in the development of some types of diabetes and they raise the possibility that Cd and diabetes-related hyperglycemia may act synergistically to damage the kidney...
  17. ncbi Genistein induces estrogen-like effects in ovariectomized rats but fails to increase cardiac GLUT4 and oxidative stress
    Layla Al-Nakkash
    Department of Physiology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona, USA
    J Med Food 13:1369-75. 2010
    ..However, based on our experimental conditions, the effects of genistein were not associated with changes in cardiac GLUT4 or oxidative stress...
  18. ncbi Characteristics of the courses that best predict COMLEX-USA level 1 performance
    Donald J Sefcik
    Department of Family Medicine, Midwestern University Chicago College of Osteopathic Medicine, 555 31st St, Downers Grove, IL 60515, USA
    J Am Osteopath Assoc 103:491-4. 2003
  19. ncbi Effects of cadmium on E-cadherin and VE-cadherin in mouse lung
    Celeste A Pearson
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Life Sci 72:1303-20. 2003
    ..These findings suggest that E-cadherin and VE-cadherin may be important early targets of Cd(2+) toxicity in the lung...
  20. ncbi Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells
    Walter C Prozialeck
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, USA
    Infect Immun 70:2605-13. 2002
    ..This could represent an important mechanism by which C. trachomatis alters epithelial cell function...
  21. ncbi Evaluation of the barrier properties of a commercially available renal epithelial cell system
    Walter C Prozialeck
    Toxicol In Vitro 21:533. 2007
  22. ncbi Culture drives research funding
    Walter C Prozialeck
    J Am Osteopath Assoc 108:353. 2008
  23. ncbi Productivity outcomes for recent grants and fellowships awarded by the American Osteopathic Association Bureau of Research
    Richard C Rose
    American Osteopathic Association in Chicago, Illinois 60611, USA
    J Am Osteopath Assoc 103:435-40. 2003
    ..The Bureau of Research grant and fellowship programs have been successful both scientifically and in terms of financial outcomes...
  24. ncbi Research in action: a summary of the 2001 American Osteopathic Association Research Conference
    Walter C Prozialeck
    J Am Osteopath Assoc 102:117-9. 2002
  25. ncbi Addressing substance abuse in medical school curricula
    Walter C Prozialeck
    J Am Osteopath Assoc 106:425-6; author reply 426. 2006

Research Grants13

  1. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2001
    ..Furthermore, the results of these studies could have more general implications concerning the mechanisms by which toxic substances damage living cells. ..
  2. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..