Guolian Kang

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi Entropy-based joint analysis for two-stage genome-wide association studies
    Guolian Kang
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    J Hum Genet 52:747-56. 2007
  2. ncbi A mixed two-stage method for detecting interactions in genomewide association studies
    Yijun Zuo
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    J Theor Biol 262:576-83. 2010
  3. ncbi Gene-centric genomewide association study via entropy
    Yuehua Cui
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    Genetics 179:637-50. 2008
  4. ncbi An entropy-based approach for testing genetic epistasis underlying complex diseases
    Guolian Kang
    Department of Statistics and Probability, East Lansing, Michigan State University, MI 48824, USA
    J Theor Biol 250:362-74. 2008
  5. ncbi Association of G72/G30 polymorphisms with early-onset and male schizophrenia
    Weihua Yue
    Institute of Mental Health, Peking University, Peking, Beijing, China
    Neuroreport 17:1899-902. 2006
  6. ncbi Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects
    Weihua Yue
    Institute of Mental Health, Peking University, Beijing, China
    Neurosci Lett 416:96-100. 2007
  7. ncbi Two-stage designs to identify the effects of SNP combinations on complex diseases
    Guolian Kang
    Key Laboratory of Systems and Control, Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, 100080, China
    J Hum Genet 53:739-46. 2008

Collaborators

Detail Information

Publications7

  1. ncbi Entropy-based joint analysis for two-stage genome-wide association studies
    Guolian Kang
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    J Hum Genet 52:747-56. 2007
    ..So, we recommend we should use entropy-based strategy for two-stage genome-wide association studies to detect the rare and common genetic variants with moderate to large genetic effect underlying a complex disease...
  2. ncbi A mixed two-stage method for detecting interactions in genomewide association studies
    Yijun Zuo
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    J Theor Biol 262:576-83. 2010
    ..In addition, we compare both two-stage methods and find that our two-stage method will lose power because we only use part of samples in both two stages...
  3. ncbi Gene-centric genomewide association study via entropy
    Yuehua Cui
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    Genetics 179:637-50. 2008
    ..As the genomewide genic SNPs become available, our entropy-based gene-centric approach would provide a robust and computationally efficient way for gene-based genomewide association study...
  4. ncbi An entropy-based approach for testing genetic epistasis underlying complex diseases
    Guolian Kang
    Department of Statistics and Probability, East Lansing, Michigan State University, MI 48824, USA
    J Theor Biol 250:362-74. 2008
    ..Our approach provides a fast and testable framework for genetic epistasis study in a case-only design...
  5. ncbi Association of G72/G30 polymorphisms with early-onset and male schizophrenia
    Weihua Yue
    Institute of Mental Health, Peking University, Peking, Beijing, China
    Neuroreport 17:1899-902. 2006
    ..009) as mentioned above in male patients. These findings suggest that the G72/G30 gene may modulate the age at onset and there might be a potential interaction between this locus and sex in the pathogenesis of schizophrenia...
  6. ncbi Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects
    Weihua Yue
    Institute of Mental Health, Peking University, Beijing, China
    Neurosci Lett 416:96-100. 2007
    ..05). These results support the hypothesis that variations in DAOA may play a role in schizophrenia and clinical characteristics...
  7. ncbi Two-stage designs to identify the effects of SNP combinations on complex diseases
    Guolian Kang
    Key Laboratory of Systems and Control, Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, 100080, China
    J Hum Genet 53:739-46. 2008
    ..Using synergistic blocks, we can reduce the dimensionality in a multi-locus association analysis, and evaluate the sizes of interactive effects among multiple disease genes on complex phenotypes...