Research Topics
Genomes and Genes | G ZhouSummaryAffiliation: Merck Research Laboratories Country: USA Publications
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Publications
Role of AMP-activated protein kinase in mechanism of metformin actionG Zhou
Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Clin Invest 108:1167-74. 2001..Activation of AMPK provides a unified explanation for the pleiotropic beneficial effects of this drug; these results also suggest that alternative means of modulating AMPK should be useful for the treatment of metabolic disorders...- Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transferG Zhou
Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Mol Endocrinol 12:1594-604. 1998..3) Nuclear receptor LBDs have distinct affinities for individual coactivators; thus, PPARgamma has a greater apparent affinity for CBP than for SRC-1, whereas ERalpha interacts preferentially with SRC-1 but very weakly with CBP... - 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cellsX Fu
Department of Atherosclerosis and Endocrinology, and Metabolic Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Biol Chem 276:38378-87. 2001..We conclude that 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload... - L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand bindingA Elbrecht
Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Biol Chem 274:7913-22. 1999..The results suggest a critical functional role for Cys313, and helix 3, in contributing to ligand binding and subsequent agonist-induced conformational changes... - Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effectsJ Berger
Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Biol Chem 274:6718-25. 1999.... - Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphateX Gan
Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Biol Chem 276:48702-8. 2001..These data indicate that activation of the Rho proteins may change the activation status of LXR... - Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expressoJ W Lawrence
Department of Safety Assessment, Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486, USA
J Biol Chem 276:31521-7. 2001..These results suggest that other factors besides PPAR alpha levels determine the species-specific response of human and rat hepatocytes to the induction of PP... - Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activationB A Johnson
Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, NJ 07065, USA
J Mol Biol 298:187-94. 2000..Our results have important implications for the mechanisms by which antagonists, partial agonists, and agonists of nuclear receptor function operate... - Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activationG Zhou
Department of Metabolic Disorders, Merck Laboratories, Rahway, New Jersey 07065, USA
Methods 25:54-61. 2001.... - A simple quantitative FT-IR approach for the study of a polymorphic transformation under crystallization slurry conditionsP J Skrdla
Merck and Co, Inc, P O Box 2000, Rahway, NJ 07065, USA
J Pharm Biomed Anal 25:731-9. 2001..Performing the experiment at various temperatures allowed the energy of activation for the process to be estimated (42 kJ/mol)... - AMPK activators--potential therapeutics for metabolic and other diseasesG Zhou
Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, USA
Acta Physiol (Oxf) 196:175-90. 2009..Activators of AMPK that target selected tissues hold potential as novel therapeutics for diseases in which altered energy metabolism contributes to aetiology... - Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gammaB Zhang
Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Biol Chem 271:31771-4. 1996..2) PPARgamma is phosphorylated in vivo by insulin stimulation or activation of the MAP kinase pathway. 3) MAP kinase is an important mediator of cross-talk between insulin signal transduction pathways and PPARgamma function... - Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndromeR Morello
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
Nat Genet 27:205-8. 2001.... - Components of a new human protein kinase signal transduction pathwayG Zhou
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606, USA
J Biol Chem 270:12665-9. 1995..Both MEK5 and ERK5 are expressed in many adult tissue and are abundant in heart and skeletal muscle. A recombinant GST-ERK5 kinase domain displays autophosphorylation on Ser/Thr and Tyr residues... - p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectivelyL Gelman
Unité 325 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille, 1, Rue du Prof Calmette, 59019 Lille Cedex, France
J Biol Chem 274:7681-8. 1999..p300/CBP displays itself at least two docking sites for PPARgamma located in its N terminus (between residues 1 and 113 for CBP) and in the middle of the protein (between residues 1099 and 1460)... - A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathwayZ Yao
Amgen, Inc, Boulder, Colorado 80301, USA
J Biol Chem 274:2118-25. 1999..These results indicate that HGK, a novel activator of the JNK pathway, may function through TAK1, and that the HGK --> TAK1 --> MKK4, MKK7 --> JNK kinase cascade may mediate the TNF-alpha signaling pathway... - Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cellsX Wu
Department of Biological Chemistry and the Institute of Gerontology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 271:3265-71. 1996..Interestingly, A-Raf does not activate MEK2, although c-Raf can activate both MEK1 and MEK2. Our data demonstrated that A-Raf is, indeed, a MEK1 activator and may play a role in growth factor signaling... - A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic miceG Zhou
Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
J Cell Sci 108:3677-84. 1995.... - Quantitative detection of single nucleotide polymorphisms for a pooled sample by a bioluminometric assay coupled with modified primer extension reactions (BAMPER)G Zhou
Hitachi Ltd, Central Research Laboratory, 1-280 Higashi-Koigakubo, Kokubunji-shi, Tokyo 185-8601, Japan
Nucleic Acids Res 29:E93. 2001..The method is sensitive enough to detect 14 amol ssM13 DNA. The proposed method seems very promising in terms of realizing a cost-effective, large-scale human genetic testing system... - Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribedK A Brayton
Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907
J Biol Chem 269:5313-21. 1994..Expression of a luciferase reporter from the GPAT promoter was approximately 3-4-fold higher than from the AIRC promoter. The GPAT gene was mapped to the q12 region of chromosome 4... - Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cellsN Keshava
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505-2845, USA
Mol Cell Biochem 222:69-76. 2001..Also, cell transformation induced by BeSO4 may be attributed, in part, to the gene amplification of K-ras and c-jun and some BeSO4-induced transformed cells possess neoplastic potential resulting from genomic instability... - Modulation of retinal cell populations and eye size in retinoic acid receptor knockout miceG Zhou
Center for Neuroscience, University of Tennessee, Memphis, TN 38163, USA
Mol Vis 7:253-60. 2001..Rara is of particular interest because this gene is a candidate for Nnc1, a QTL that controls retinal ganglion cell proliferation... - Linkage disequilibrium and haplotype architecture for two ABC transporter genes (ABCC1 and ABCG2) in Chinese population: implications for pharmacogenomic association studiesH Wang
Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing 100850 PR China
Ann Hum Genet 68:563-73. 2004..Our data will benefit genetic association studies of complex traits and drug response possibly related to these genes... - A Chinese isolate of barley yellow dwarf virus-PAV represents a third distinct species within the PAV serotypeF Liu
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, PR China
Arch Virol 152:1365-73. 2007..These data suggest that PAV-CN may have undergone a recombination event with GAV and that PAV-CN represents a third distinct species within the PAV serotype of BYDV... - Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cellsC Zhang
Institute of Pathology and Pathophysiology, Shandong University School of Medicine, Jinan 250012, People s Republic of China
J Pathol 212:134-42. 2007..Our results thus suggest that epigenetic inactivation of TMS1 expression is regulated by promoter hypermethylation and H3K9 modifications in a coordinated way... - Gene expression profiling of breast cells induced by X-rays and heavy ionsD Roy
Department of Natural Sciences, Hostos College of the City University of New York, Bronx, NY 10541, USA
Int J Mol Med 21:627-36. 2008..A number of candidate genes reported here may be useful molecular biomarkers of radiation exposure in breast cells... - Modulation of zeta-protein kinase C by cyclic AMP in PC12 cells occurs through phosphorylation by protein kinase AM W Wooten
Department of Zoology, Auburn University, AL 36849-5414, USA
J Neurochem 67:1023-31. 1996..Taken together, these findings are consistent with the hypothesis that protein phosphorylation of PKC acts as a positive effector of its enzyme activity and may serve as a negative modulator for interaction with other proteins... - An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytesV Lefebvre
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Mol Cell Biol 16:4512-23. 1996..Together, our results indicate that an 18-bp sequence in Col2a1 intron 1 controls chondrocyte expression and suggest that RCS cells and chondrocytes contain specific POU domain proteins involved in enhancer activity... - Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivoG Zhou
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 273:14989-97. 1998..Overall our results suggest a model whereby both Sox9 and these other proteins bind to several HMG-like sites in the Col2a1 gene to cooperatively control its expression in cartilage... - The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart developmentF A Pereira
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 USA
Genes Dev 13:1037-49. 1999..This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development... - Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascadeG Zhou
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 274:13133-8. 1999..Taken together, these studies establish a potential cascade of TGF-beta-activated interacting kinases beginning with HPK1, a Ste20 homolog, and ending in JNK1 activation: HPK1 --> TAK1 --> SEK --> JNK1... - Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndromeS D Dreyer
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA
Nat Genet 19:47-50. 1998..Furthermore, we provide evidence for the first described mutations in a LIM-homeodomain protein which account for an inherited form of abnormal skeletal patterning and renal failure... - CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasiaG Zhou
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, 630E, Houston, TX 77030, USA
Hum Mol Genet 8:2311-6. 1999..Together these data show that variable loss of function due to alterations in the runt and PST domains of CBFA1 may give rise to clinical variability, including classic CCD, mild CCD and isolated primary dental anomalies... - A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1D Ensenat
Department of Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 274:33945-50. 1999..Our results identify a novel protein, HIP-55, that binds to HPK1 and regulates the JNK1 signaling cascade... - Partial cloning and sequencing of chick fibrillin-1 cDNAG Zhou
Munroe Center for Human Genetics, University of Nebraska Medical Center, Omaha 68198 5430, USA
In Vitro Cell Dev Biol Anim 36:19-25. 2000..Antisense and sense riboprobes were synthesized and used in in situ hybridization in stage 14 chick embryos and high levels of FBN1 transcripts were observed in the heart... - Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinaseZ Yao
Amgen Inc, Boulder, Colorado 80301, USA
J Biol Chem 272:32378-83. 1997..Thus, MKK7 is a new member of the MAPK kinase family that functions upstream of SAPK/JNK in the SAPK/JNK signaling pathway... - Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cellsG Zhou
Department of Zoology, Auburn University, Auburn, Alabama 36849 5414, USA
J Biol Chem 272:31130-7. 1997..Taken together, the findings presented herein document that nucleolin is a target of PKC-zeta that serves to relay NGF signals from cell surface to nucleus in PC12 cells... - Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transductionW Wang
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 272:22771-5. 1997..Our results also suggest the potential roles of TAK1 not only in the TGF-beta pathway but also in the other HPK1/JNK1-mediated pathways... - Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasivenessZ Tang
Liver Cancer Institute, Shanghai Medical University, China
Chin Med J (Engl) 111:313-8. 1998..To make a better understanding of the molecular mechanisms involved in recurrence and metastasis of the hepatocellular carcinoma (HCC), some invasion related oncogenes, and growth factors have been investigated...