Liangsu Wang

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi A genome-wide strategy for the identification of essential genes in Staphylococcus aureus
    R Allyn Forsyth
    Elitra Pharmaceuticals, San Diego, CA 92121, USA
    Mol Microbiol 43:1387-400. 2002
  2. ncbi Genome-wide operon prediction in Staphylococcus aureus
    Liangsu Wang
    Elitra Pharmaceuticals Inc, 10410 Science Center Drive, San Diego, CA 92121, USA
    Nucleic Acids Res 32:3689-702. 2004
  3. ncbi Pharmacoeconomics of treatment with the newer anti-Gram-positive agents
    Liangsu Wang
    Department of Infectious Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
    Expert Opin Pharmacother 7:885-97. 2006
  4. ncbi Development of an integrated semi-automated system for in vitro pharmacodynamic modelling
    Liangsu Wang
    Department of Infectious Disease Research, Merck Research Laboratories, 126 E Lincoln Avenue, Rahway, NJ 07065, USA
    J Antimicrob Chemother 62:1070-7. 2008
  5. ncbi Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials
    H Howard Xu
    Elitra Pharmaceuticals, San Diego, California 92121, USA
    Antimicrob Agents Chemother 54:3659-70. 2010
  6. ncbi Control and prevention of MRSA infections
    Liangsu Wang
    Infectious Disease Research, Merck and Co Inc, Rahway, NJ, USA
    Methods Mol Biol 391:209-25. 2007
  7. ncbi A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds
    Robert G K Donald
    Merck Research Laboratories, Merck and Co, Rahway, NJ 07065, USA
    Chem Biol 16:826-36. 2009
  8. ncbi Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus
    Allyn Forsyth
    GHC Technologies, Inc, La Jolla, CA, USA
    Methods Mol Biol 416:307-21. 2008

Collaborators

Detail Information

Publications8

  1. ncbi A genome-wide strategy for the identification of essential genes in Staphylococcus aureus
    R Allyn Forsyth
    Elitra Pharmaceuticals, San Diego, CA 92121, USA
    Mol Microbiol 43:1387-400. 2002
    ..This approach enables facile assay development for high throughput screening for any essential gene, independent of its biochemical function, thereby greatly facilitating the search for new antibiotics...
  2. ncbi Genome-wide operon prediction in Staphylococcus aureus
    Liangsu Wang
    Elitra Pharmaceuticals Inc, 10410 Science Center Drive, San Diego, CA 92121, USA
    Nucleic Acids Res 32:3689-702. 2004
    ..This consensus approach has enabled us to predict operons with high accuracy from a genome where limited experimental evidence for operon structure is available...
  3. ncbi Pharmacoeconomics of treatment with the newer anti-Gram-positive agents
    Liangsu Wang
    Department of Infectious Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
    Expert Opin Pharmacother 7:885-97. 2006
    ..e., spectrum, activity, resistance emergence, efficacy, target, safety) provide a basis for an emerging pharmacoeconomic-based distinction between these newer anti-Gram-positive agents...
  4. ncbi Development of an integrated semi-automated system for in vitro pharmacodynamic modelling
    Liangsu Wang
    Department of Infectious Disease Research, Merck Research Laboratories, 126 E Lincoln Avenue, Rahway, NJ 07065, USA
    J Antimicrob Chemother 62:1070-7. 2008
    ..The aim of this study was to develop an integrated system for in vitro pharmacodynamic modelling of antimicrobials with greater flexibility, easier control and better accuracy than existing in vitro models...
  5. ncbi Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials
    H Howard Xu
    Elitra Pharmaceuticals, San Diego, California 92121, USA
    Antimicrob Agents Chemother 54:3659-70. 2010
    ..A rapid detection method measures strain responses toward antibiotics. The TargetArray antibiotic fitness test results show mechanistically informative biological fingerprints that allow MOA elucidation...
  6. ncbi Control and prevention of MRSA infections
    Liangsu Wang
    Infectious Disease Research, Merck and Co Inc, Rahway, NJ, USA
    Methods Mol Biol 391:209-25. 2007
    ..With the realization that MRSA is now a community problem, there are expanded efforts toward more direct intervention, such as the use of anti-MRSA antibacterials and vaccines, in an attempt to reduce the overall burden of MRSA...
  7. ncbi A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds
    Robert G K Donald
    Merck Research Laboratories, Merck and Co, Rahway, NJ 07065, USA
    Chem Biol 16:826-36. 2009
    ..2009), demonstrate its use in the discovery of new cell wall inhibitors...
  8. ncbi Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus
    Allyn Forsyth
    GHC Technologies, Inc, La Jolla, CA, USA
    Methods Mol Biol 416:307-21. 2008
    ..Antisense RNA strategies have high utility when the target gene is essential for survival and needs to be compared with wild type...