Dietrich Steinhuebel

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Enol tosylates as viable partners in Pd-catalyzed cross-coupling reactions
    Dietrich Steinhuebel
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    J Org Chem 70:10124-7. 2005
  2. ncbi Controlling olefin geometry with Pd catalysis: selective formation of Z-olefins from both E- and Z-allylic carbonates
    Dietrich Steinhuebel
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    J Org Chem 71:3282-4. 2006
  3. ncbi Direct asymmetric reductive amination
    Dietrich Steinhuebel
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    J Am Chem Soc 131:11316-7. 2009
  4. ncbi Asymmetric hydrogenation of protected allylic amines
    Dietrich P Steinhuebel
    Department of Process Research, Merck and Co Inc, PO Box 2000, Rahway, New Jersey 07065, USA
    Org Lett 12:4201-3. 2010
  5. ncbi Stereoselective enol tosylation: preparation of trisubstituted alpha,beta-unsaturated esters
    Jenny M Baxter
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    Org Lett 7:215-8. 2005
  6. ncbi One-step synthesis of alpha-chloro acetophenones from acid chlorides and aryl precursors
    Jonathan Rosen
    Merck and Company, Inc, Department of Process Research, P O Box 2000, Rahway, New Jersey 07065, USA
    Org Lett 9:667-9. 2007

Detail Information

Publications6

  1. ncbi Enol tosylates as viable partners in Pd-catalyzed cross-coupling reactions
    Dietrich Steinhuebel
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    J Org Chem 70:10124-7. 2005
    ..reaction: see text] Herein we demonstrate functionalized enol tosylates to be robust substrates that undergo Suzuki-Miyaura, Sonogashira, and Stille cross-coupling reactions to provide stereodefined trisubstituted unsaturated esters...
  2. ncbi Controlling olefin geometry with Pd catalysis: selective formation of Z-olefins from both E- and Z-allylic carbonates
    Dietrich Steinhuebel
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    J Org Chem 71:3282-4. 2006
    ..The reaction is selective for the Z-isomer, and either acetyl, Boc, or formyl protecting groups are tolerated. The Z-olefin product can be formed regardless of whether the E- or Z-allylic carbonate is used as starting material...
  3. ncbi Direct asymmetric reductive amination
    Dietrich Steinhuebel
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    J Am Chem Soc 131:11316-7. 2009
    ..The excellent reaction efficiency is attributed to the remarkable tolerance to high concentrations of ammonium ion, the high chemoselectivity, and the high enantioselectivity (99.5% ee) of the Ru catalyst system...
  4. ncbi Asymmetric hydrogenation of protected allylic amines
    Dietrich P Steinhuebel
    Department of Process Research, Merck and Co Inc, PO Box 2000, Rahway, New Jersey 07065, USA
    Org Lett 12:4201-3. 2010
    ..The scope of the hydrogenation reaction was studied, and a variety of substituted allylic amine derivatives could be hydrogenated with enantiomeric ratios of 92:8 or higher...
  5. ncbi Stereoselective enol tosylation: preparation of trisubstituted alpha,beta-unsaturated esters
    Jenny M Baxter
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    Org Lett 7:215-8. 2005
    ..The enol tosylates are stable, crystalline compounds that undergo smooth and effective Suzuki-Miyaura coupling reaction with a variety of aryl boronic acids...
  6. ncbi One-step synthesis of alpha-chloro acetophenones from acid chlorides and aryl precursors
    Jonathan Rosen
    Merck and Company, Inc, Department of Process Research, P O Box 2000, Rahway, New Jersey 07065, USA
    Org Lett 9:667-9. 2007
    ..This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel-Crafts chemistry. [reaction: see text]...