D J Hazuda

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    D J Hazuda
    Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA
    Science 287:646-50. 2000
  2. ncbi Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity
    S B Singh
    Natural Products Drug Discovery, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 10:235-8. 2000
  3. ncbi New antiretroviral agents: looking beyond protease and reverse transcriptase
    M D Miller
    Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Curr Opin Microbiol 4:535-9. 2001

Collaborators

  • M D Miller
  • S B Singh
  • P Felock

Detail Information

Publications3

  1. ncbi Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    D J Hazuda
    Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA
    Science 287:646-50. 2000
    ..The antiviral activity of these compounds is due exclusively to inhibition of one of the two catalytic functions of integrase, strand transfer...
  2. ncbi Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity
    S B Singh
    Natural Products Drug Discovery, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 10:235-8. 2000
    ..In contrast, inhibition of 3' processing activity is less stringent suggesting distinct SAR for the two integrase reactions...
  3. ncbi New antiretroviral agents: looking beyond protease and reverse transcriptase
    M D Miller
    Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Curr Opin Microbiol 4:535-9. 2001
    ..The most recent preclinical advances in novel antiretroviral agents are reviewed and promising new approaches that target viral processes are highlighted...