Lynne A Murray

Summary

Affiliation: MedImmune Vaccines
Country: USA

Publications

  1. ncbi Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes
    Jason E Ekert
    Departments of Cell Biology and Assay Technologies, Centocor R and D, a division of Johnson and Johnson Pharmaceutical Research and Development, LLC, Radnor, PA, USA
    Fibrogenesis Tissue Repair 4:23. 2011
  2. ncbi Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor ?1-induced lung fibrosis
    Xueyan Peng
    Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, TAC 441S, New Haven, CT, USA
    Fibrogenesis Tissue Repair 4:12. 2011
  3. ncbi Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages
    Lynne A Murray
    Promedior, Inc, Malvern, Pennsylvania, United States of America
    PLoS ONE 5:e9683. 2010
  4. ncbi Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis
    Lynne A Murray
    Promedior, Inc, 371 Phoenixville Pike, Malvern, PA, 19355, USA
    Fibrogenesis Tissue Repair 3:11. 2010
  5. ncbi Deleterious role of TLR3 during hyperoxia-induced acute lung injury
    Lynne A Murray
    Immunobiology Department, Centocor, Radnor, PA, USA
    Am J Respir Crit Care Med 178:1227-37. 2008
  6. ncbi TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P
    Lynne A Murray
    Promedior, Inc 371 Phoenixville Pike, Malvern, PA, USA
    Int J Biochem Cell Biol 43:154-62. 2011
  7. ncbi BMP-7 does not protect against bleomycin-induced lung or skin fibrosis
    Lynne A Murray
    Immunobiology Department, Centocor, Radnor, Pennsylvania, USA
    PLoS ONE 3:e4039. 2008
  8. ncbi Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice
    Nicole C Stowell
    Discovery Research, Centocor Research and Development, Inc, Radnor, Pennsylvania, USA
    Respir Res 10:43. 2009

Collaborators

Detail Information

Publications8

  1. ncbi Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes
    Jason E Ekert
    Departments of Cell Biology and Assay Technologies, Centocor R and D, a division of Johnson and Johnson Pharmaceutical Research and Development, LLC, Radnor, PA, USA
    Fibrogenesis Tissue Repair 4:23. 2011
    ..abstract:..
  2. ncbi Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor ?1-induced lung fibrosis
    Xueyan Peng
    Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, TAC 441S, New Haven, CT, USA
    Fibrogenesis Tissue Repair 4:12. 2011
    ..abstract:..
  3. ncbi Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages
    Lynne A Murray
    Promedior, Inc, Malvern, Pennsylvania, United States of America
    PLoS ONE 5:e9683. 2010
    ..These data highlight the role of macrophages in fibrotic lung disease, and demonstrate a therapeutic action of SAP on macrophages which may extend to many fibrotic indications caused by over-exuberant pro-fibrotic macrophage responses...
  4. ncbi Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis
    Lynne A Murray
    Promedior, Inc, 371 Phoenixville Pike, Malvern, PA, 19355, USA
    Fibrogenesis Tissue Repair 3:11. 2010
    ..To evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model...
  5. ncbi Deleterious role of TLR3 during hyperoxia-induced acute lung injury
    Lynne A Murray
    Immunobiology Department, Centocor, Radnor, PA, USA
    Am J Respir Crit Care Med 178:1227-37. 2008
    ..Patients with ARDS are highly susceptible to viral infection and it may be due to altered Toll-like receptor (TLR) expression...
  6. ncbi TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P
    Lynne A Murray
    Promedior, Inc 371 Phoenixville Pike, Malvern, PA, USA
    Int J Biochem Cell Biol 43:154-62. 2011
    ..These data suggest that the beneficial anti-fibrotic effects of SAP in TGF?(1)-induced lung disease are via modulating monocyte responses...
  7. ncbi BMP-7 does not protect against bleomycin-induced lung or skin fibrosis
    Lynne A Murray
    Immunobiology Department, Centocor, Radnor, Pennsylvania, USA
    PLoS ONE 3:e4039. 2008
    ..Taken together our data indicates that BMP-7 has no anti-fibrotic effect in lung or skin fibrosis either in vivo or in vitro. This suggests that the therapeutic options for BMP-7 may be confined to the renal compartment...
  8. ncbi Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice
    Nicole C Stowell
    Discovery Research, Centocor Research and Development, Inc, Radnor, Pennsylvania, USA
    Respir Res 10:43. 2009
    ..Thus, an understanding of TLR3 activation should provide insight into the mechanisms underlying virus-induced exacerbations of pulmonary diseases...