Research Topics
| A StadnickaSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Detail Information
Publications
Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channelsA Stadnicka
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 90:1671-83. 1999..This study evaluated the mechanisms of volatile anesthetic actions on the cloned human cardiac sodium channel (hH1a) alpha subunit...- Impact of in vivo preconditioning by isoflurane on adenosine triphosphate-sensitive potassium channels in the rat heart: lasting modulation of nucleotide sensitivity during early memory periodAnna Stadnicka
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Anesthesiology 104:503-10. 2006.... - Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and voltage-activated potassium channelsAnna Stadnicka
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Pharmacol Exp Ther 330:727-35. 2009..We conclude that differential function and expression of BK channels, resulting from genetic variation within chromosome 13, contribute to the enhanced propofol sensitivity in SS and BN-13(SS)/Mcwi versus BN and SS-13(BN)/Mcwi strains... - Isoflurane decreases ATP sensitivity of guinea pig cardiac sarcolemmal KATP channel at reduced intracellular pHAnna Stadnicka
Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 98:396-403. 2003..Because pH is one of the regulators of K(atp) channels, the authors tested the hypothesis that intracellular pH (pHi) modulates the direct interaction of isoflurane with the cardiac K(atp) channel... - Protein tyrosine kinase-dependent modulation of isoflurane effects on cardiac sarcolemmal K(ATP) channelAnna Stadnicka
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 97:1198-208. 2002.... - Modulation of cardiac inward rectifier K(+)current by halothane and isofluraneA Stadnicka
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Anesth Analg 90:824-33. 2000..IMPLICATIONS: Differential modulation of myocardial inward rectifier potassium current by volatile anesthetics under normal and altered rectification may contribute to the mechanism of dysrhythmic actions by these anesthetics... - Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidilSusanne Gassmayr
Department of Anesthesiology. double dagger Assistant Professor, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Anesthesiology 98:114-20. 2003..Blockade of adenosine receptors or phosphatidylinositol kinases abolishes the sensitization effect, suggesting that the adenosine and phospholipid signaling pathways may be involved in the actions by isoflurane... - Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activityYasushi Mio
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Anesthesiology 108:612-20. 2008..Here, the impact of age on the role of two major effectors of APC, mitochondria and sarcolemmal adenosine triphosphate-sensitive potassium (sarcKATP) channels, in preconditioning of the human atrial myocardium were investigated... - Role of sarcolemmal ATP-sensitive potassium channel in oxidative stress-induced apoptosis: mitochondrial connectionJasna Marinovic
Department of Anesthesiology, Medical College of Wisconsin, Miwaukee, WI 53226, USA
Am J Physiol Heart Circ Physiol 294:H1317-25. 2008.... - Volatile anesthetic-induced cardiac preconditioningAnna Stadnicka
Department of Anesthesiology, Medical College of Wisconsin, MEB M4280, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
J Anesth 21:212-9. 2007..Moreover, the article addresses current concepts and controversies regarding the specific roles of the mitochondrial and the sarcolemmal K(ATP) channels in APC... - Isoflurane preconditioning uncouples mitochondria and protects against hypoxia-reoxygenationMarko Ljubkovic
Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Cell Physiol 292:C1583-90. 2007..In conclusion, isoflurane preconditioning elicits partial mitochondrial uncoupling and reduces mitochondrial Ca(2+) uptake. These effects are likely to reduce the extent of the mitochondrial damage after the hypoxic stress... - Mechanism of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel activation by isoflurane in a heterologous expression systemMartin Bienengraeber
Department of Anesthesiology, Medical College of Wisconsin, Wisconsin 53226, USA
Anesthesiology 105:534-40. 2006..These findings support direct and differential interaction of isoflurane with the subunits of the cardiac sarcolemmal KATP channel... - Distinct roles for sarcolemmal and mitochondrial adenosine triphosphate-sensitive potassium channels in isoflurane-induced protection against oxidative stressJasna Marinovic
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 105:98-104. 2006..Sarcolemmal K(ATP) channel seems to act as an effector of preconditioning, whereas mitochondrial K(ATP) channel plays a dual role as a trigger and an effector... - Differential modulation of the cardiac adenosine triphosphate-sensitive potassium channel by isoflurane and halothaneWai Meng Kwok
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Anesthesiology 97:50-6. 2002..The goal of this study was to investigate the ability of volatile anesthetics halothane and isoflurane to modulate the cardiac sarcolemmal K(ATP) channel... - The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channelsLawrence A Turner
Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Anesth Analg 100:1680-6. 2005.... - Contribution of reactive oxygen species to isoflurane-induced sensitization of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidilJianzhong An
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 100:575-80. 2004..1 +/- 3.8 pA/pF (n= 6). CONCLUSION: These results suggest that reactive oxygen species contribute to the mechanism by which isoflurane sensitizes the cardiac sarcolemmal K(ATP) channel to the opener, pinacidil... - Preconditioning by isoflurane induces lasting sensitization of the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel by a protein kinase C-delta-mediated mechanismJasna Marinovic
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Anesthesiology 103:540-7. 2005..Our results indicate that protein kinase C-delta, rather than protein kinase C-epsilon, is a likely mediator of isoflurane effects, although both protein kinase C-delta and protein kinase C-epsilon can modulate the channel function...