Research Topics
Genomes and Genes | Cynthia M SmasSummaryAffiliation: Medical University of Ohio Country: USA Publications
|
Detail Information
Publications
The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgammaJi Young Kim
Dept of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, OH 43614, USA
Am J Physiol Endocrinol Metab 291:E115-27. 2006..Our findings identify the novel lipase ATGL to be a target gene for TNF-alpha and insulin action in adipocytes and reveal that it is subject to transcriptional control by PPARgamma-mediated signals...- Assessment of fat-specific protein 27 in the adipocyte lineage suggests a dual role for FSP27 in adipocyte metabolism and cell deathJi Young Kim
Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA
Am J Physiol Endocrinol Metab 294:E654-67. 2008..This suggests that adipogenesis is accompanied by decreased susceptibility to the proapoptotic effects of FSP27. Overall, our findings support roles for FSP27 in cell death and in adipocyte function... - Differentiation-dependent expression of Adhfe1 in adipogenesisJi Young Kim
Department of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, OH 43614, USA
Arch Biochem Biophys 464:100-11. 2007..In comparison to C57BL/6 mice, Adhfe1 transcript is downregulated 40% in white adipose tissue of ob/ob obese mice. Further characterization of Adhfe1 should yield new insights into adipocyte function and energy metabolism... - Differential screening identifies transcripts with depot-dependent expression in white adipose tissuesYu Wu
Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA
BMC Genomics 9:397. 2008..To identify such genes, we prepared subtractive cDNA libraries from murine subcutaneous (SC) or intra-abdominal epididymal (EP) white adipocytes... - Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEAKun Liu
Department of Biochemistry and Cancer Biology and Center for Diabetes and Endocrine Research, The University of Toledo College of Medicine, Toledo, Ohio 43614, USA
Am J Physiol Endocrinol Metab 297:E1395-413. 2009..Overall, our findings demonstrate the function of the FSP27 CIDE C domain and/or regions thereof for apoptosis, lipid droplet localization, and CIDEA interaction... - Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytesJi Young Kim
Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, Ohio 43614, USA
Physiol Genomics 31:328-42. 2007..This suggests that comparative gene expression studies of ScAP-23 and 3T3-L1 adipogenesis may be particularly fruitful in identifying preadipocyte-expressed genes that play a role in adipose tissue physiology and/or pathophysiology... - Downregulated expression of the secreted glycoprotein follistatin-like 1 (Fstl1) is a robust hallmark of preadipocyte to adipocyte conversionYu Wu
Department of Biochemistry and Cancer Biology, Center for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, OH 43614, USA
Mech Dev 127:183-202. 2010..Together, our data suggest downregulation of Fstl1 expression may be an important feature of preadipocyte to adipocyte conversion... - Wdnm1-like, a new adipokine with a role in MMP-2 activationYu Wu
Department of Biochemistry and Cancer Biology and Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, Toledo, OH 43614, USA
Am J Physiol Endocrinol Metab 295:E205-15. 2008..We postulate that Wdnm1-like may play roles in remodeling of the extracellular milieu in adipogenesis, as well as in tumor microenvironments where adipocytes are key stromal components... - Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12Jun Ho Lee
Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
J Cell Biochem 111:195-206. 2010..Together, these biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action... - The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissueJi Young Kim
Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3000 Arlington Ave, Toledo, OH 43614, USA
Am J Physiol Endocrinol Metab 293:E110-20. 2007..We postulate that the function of this macrophage-specific putative sugar transporter is central to the metabolism of the macrophage population specifically present in obese WAT... - Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesisJi Young Kim
Department of Biochemistry and Cancer Biology, Medical College of Ohio, Toledo, OH 43614, USA
Biochem Biophys Res Commun 326:36-44. 2005..These data indicate that SMAF1 is closely tied to the adipocyte phenotype and predict a novel and possibly regulatory role for this gene in adipocyte function... - Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineageYu Wu
Department of Biochemistry and Cancer Biology and Center for Diabetes and Endocrine Research, University of Toledo, Health Science Campus, Toledo, OH 43614, USA
BMC Res Notes 1:85. 2008..White adipose tissue is not only an energy storage organ; it also functions as an endocrine organ. The coordination and integration of numerous gene expression events is required to establish and maintain the adipocyte phenotype... - Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposityYang Soo Moon
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
Mol Cell Biol 22:5585-92. 2002..We also suggest that Pref-1 is responsible for most of the symptoms observed in mouse mUPD12 and human mUPD14. Pref-1-null mice may be a model for obesity and other pathologies of human mUPD14...