Research Topics
Genomes and GenesSpecies | Subra KugathasanSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's diseaseSubra Kugathasan
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Inflamm Bowel Dis 11:631-8. 2005..The first identified CD susceptibility gene, CARD15, seems to be present in up to 40% of white children with CD. However, the frequency of this gene among patients with CD of other racial/ethnic groups in the United States is not known...- Pancreatitis as a presenting manifestation of pediatric Crohn's disease: a report of three casesSubra Kugathasan
Division of Gastroenterology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, The Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Pediatr Gastroenterol Nutr 35:96-8. 2002 - Dermatologic manifestations of Crohn disease in children: response to infliximabSubra Kugathasan
Division of Pediatric Gastroenterology and Nutrition, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Pediatr Gastroenterol Nutr 37:150-4. 2003..No adverse reactions occurred. Infliximab should be considered for treating the extraintestinal dermatologic manifestations of Crohn disease in children... - Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based studySubra Kugathasan
Division of Pediatric Gastroenterology and Nutrition, The Department of Epidemiology and Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Pediatr 143:525-31. 2003..To define epidemiologic and clinical characteristics of newly diagnosed pediatric inflammatory bowel disease (IBD) in a large population-based model... - Inflammatory bowel disease--environmental modification and genetic determinantsSubra Kugathasan
Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Pediatr Clin North Am 53:727-49. 2006..Technical advances of the HapMap project and the promise of whole genome association scans have given hopes for clarifying gene-environmental interactions in IBD that ultimately lead to a clearer understanding of the pathogenesis... - Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohortsSubra Kugathasan
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Pediatr 151:523-7. 2007..To conduct a systematic review of children with newly diagnosed inflammatory bowel disease (IBD) from 2 prospective inception cohorts to examine body mass index (BMI) status at presentation... - Severe colitis in childrenSubra Kugathasan
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Pediatr Gastroenterol Nutr 41:375-85. 2005 - CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's diseaseSubra Kugathasan
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
Clin Gastroenterol Hepatol 2:1003-9. 2004..We investigated the effect of CARD15 mutations on disease manifestation, disease progression, and the risk for early surgery in childhood-onset CD... - Intercenter variation in initial management of children with Crohn's diseaseMichael D Kappelman
Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts 02115, USA
Inflamm Bowel Dis 13:890-5. 2007..We undertook this study to determine the extent of intercenter variation in the initial management of children newly diagnosed with Crohn's disease... - Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's diseaseUmesh Babusukumar
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Gastroenterol 101:1354-61. 2006..We performed a comprehensive analysis of OCTN variants in an independent, exclusively pediatric onset CD cohort and examined the genotype/phenotype correlations... - DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's diseaseVincent Biank
Department of Pediatrics, Medical College Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Gastroenterol 102:391-8. 2007..Pediatric onset CD features a significantly lower incidence for female children compared with male children. We, therefore, studied the influence of gender on R30Q susceptibility in an exclusively pediatric onset IBD cohort... - Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel diseaseSubra Kugathasan
Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Nat Genet 40:1211-5. 2008..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively... - Increased immune reactivity predicts aggressive complicating Crohn's disease in childrenMarla C Dubinsky
Department of Pediatrics, IBD Center, Cedars Sinai Medical Center, Los Angeles, California, USA
Clin Gastroenterol Hepatol 6:1105-11. 2008..The aims of this study were to determine whether immune responses and/or CARD15 variants are associated with complicated disease phenotypes and predict disease progression... - Pediatric inflammatory bowel disease: clinical and molecular geneticsVincent Biank
Department of Pediatrics, Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Inflamm Bowel Dis 13:1430-8. 2007..Finally, the future directions of genetic investigations in pediatric IBD are discussed... - Fecal calprotectin is useful in predicting disease relapse in pediatric inflammatory bowel diseaseDorota Walkiewicz
Department of Pediatrics, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
Inflamm Bowel Dis 14:669-73. 2008..The aim was to compare FC levels in IBD and healthy controls, to correlate FC levels with clinical disease activity, and to assess whether FC levels can be used to predict clinical relapse in children with IBD... - Molecular stratification of Crohn's disease by chemokine receptors: fractalkine receptor polymorphisms define a fibrostenosing ileal subgroupDavid G Binion
Division of Gastroenterology and Hepatology, Froedtert Memorial Lutheran Hospital, Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Gastroenterol 101:107-9. 2006.... - Functional genomics and its implications for molecular medicineUlrich Broeckel
Department of Medicine, Medical College of Wisconsin, and Department of Pediatrics, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Pediatr Clin North Am 53:807-16, vii. 2006..Ultimately how the unique genetic signature of an individual influences the risk and prognosis of disease will be the basis for individualized medicine in the years to come... - Progress in basic inflammatory bowel disease researchSubra Kugathasan
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Semin Pediatr Surg 16:146-53. 2007.... - Pancreatitis in childrenSteven L Werlin
Department of Pediatrics, The Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
J Pediatr Gastroenterol Nutr 37:591-5. 2003..To determine the incidence, etiology and outcome of pancreatitis at a regional children's hospital... - Brief report: development of the inflammatory bowel disease family responsibility questionnaireRachel Neff Greenley
Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Pediatr Psychol 35:183-7. 2010..To present psychometric data on youth and parent versions of the Inflammatory Bowel Disease-Family Responsibility Questionnaire (IBD-FRQ), a measure of family involvement in IBD management... - Asymptomatic inflammatory bowel disease presenting with mucocutaneous findingsSheila S Galbraith
Department of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Pediatrics 116:e439-44. 2005.... - Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosisVincent F Biank
Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Medical College of Wisconsin, The Children s Hospital of Wisconsin, Milwaukee, WI, USA
J Pediatr 159:808-12. 2011.... - Pediatric inflammatory bowel disease: highlighting pediatric differences in IBDCary G Sauer
Department of Pediatrics, Emory University School of Medicine, Emory Children s Center, 2015 Uppergate Drive, Atlanta, GA 30322, USA
Gastroenterol Clin North Am 38:611-28. 2009..Evidence-based treatment algorithms, with special focus on pediatric studies and care for children, are also highlighted... - Infliximab retreatment in adults and children with Crohn's disease: risk factors for the development of delayed severe systemic reactionSubra Kugathasan
Department of Medicine, Digestive Disease Center, Children's Hospital of Wisconsin, Milwaukee, USA
Am J Gastroenterol 97:1408-14. 2002..We recommend multiple early infusions of infliximab if retreatment is anticipated in adult patients to avoid the development of delayed severe systemic reactions... - Genetic determinants of pediatric inflammatory bowel disease: is age of onset genetically determined?Rebecca Scherr
Department of Pediatrics, Emory University School of Medicine and Children s Health Care of Atlanta, Atlanta, GA 30322, USA
Dig Dis 27:236-9. 2009..A future joint analysis of genome-wide association data of early- and late-onset cohorts will likely reveal more IBD risk variants since the power to detect small effects of genes increases... - Inflammatory bowel diseaseDaryl Fish
Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Adolesc Med Clin 15:67-90, ix. 2004.... - Barriers to adherence among adolescents with inflammatory bowel diseaseRachel Neff Greenley
Medical College of Wisconsin, Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Milwaukee, Wisconsin 53226, USA
Inflamm Bowel Dis 16:36-41. 2010..A final goal was to examine relationships between the frequencies of barriers and levels of nonadherence... - Effect of early immunomodulator use in moderate to severe pediatric Crohn diseaseJaya Punati
Nationwide Children s Hospital, Ohio State University, Columbus, Ohio 43210, USA
Inflamm Bowel Dis 14:949-54. 2008..We describe IM use in newly diagnosed pediatric CD, comparing outcomes of "early" versus "late" initiation of therapy... - CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian populationMárcia Luiza Baptista
Department of Internal Medicine, Federal University of Parana, Curitiba, PR
Inflamm Bowel Dis 14:674-9. 2008..We investigated the contribution of CARD15, IL23R, and ATG16L1 with CD risk in a heterogeneous Brazilian population... - Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibilityArie Levine
Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Inflamm Bowel Dis 13:1509-15. 2007..Differences in disease site by age may suggest a different genotype, or different host responses such as decreased ileal susceptibility or increased susceptibility of the colon... - Searching for new clues in inflammatory bowel disease: tell tales from pediatric IBD natural history studiesSubra Kugathasan
Gastroenterology 135:1038-41. 2008 - Laboratory values for children with newly diagnosed inflammatory bowel diseaseDavid R Mack
Department of Pediatrics, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Ontario, Canada K1H 8L1
Pediatrics 119:1113-9. 2007..The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease... - The natural history of corticosteroid therapy for ulcerative colitis in childrenJeffrey Hyams
Connecticut Children s Medical Center, Hartford, Connecticut, USA
Clin Gastroenterol Hepatol 4:1118-23. 2006..The aim of this study was to determine the clinical outcome after corticosteroid therapy in children who are newly diagnosed with ulcerative colitis (UC)... - Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel diseaseAnthony R Otley
FRCPC, Division of Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia, Canada
Inflamm Bowel Dis 12:684-91. 2006..The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis... - Corticosteroid therapy in the age of infliximab: acute and 1-year outcomes in newly diagnosed children with Crohn's diseaseJames Markowitz
North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
Clin Gastroenterol Hepatol 4:1124-9. 2006..We also aimed to determine whether there are clinical or laboratory characteristics associated with corticosteroid therapy outcomes... - Natalizumab therapy for moderate to severe Crohn disease in adolescentsJeffrey S Hyams
Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
J Pediatr Gastroenterol Nutr 44:185-91. 2007..This study evaluated the safety, tolerability, and efficacy of natalizumab, a humanized monoclonal immunoglobulin-G4 antibody to [alpha]4 integrin, in adolescent patients with moderately to severely active Crohn disease (CD)... - Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in childrenJeffrey Hyams
Connecticut Children s Medical Center, Hartford, Conneticut 06106, USA
Gastroenterology 132:863-73; quiz 1165-6. 2007..The REACH study evaluated the safety and efficacy of infliximab in children with moderately to severely active Crohn's disease... - Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of AmericaAthos Bousvaros
J Pediatr Gastroenterol Nutr 44:653-74. 2007..quot; The authors hope that progress being made in genetic, serological, and imaging studies leads to more reliable phenotyping... - Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel diseaseGuo Zhong Tao
Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, California 94304, USA
Clin Gastroenterol Hepatol 5:857-64. 2007..We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD... - Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in menFrauke Friedrichs
Leibniz Institute for Arteriosclerosis Research, Domagkstr 3, 48149, Muenster, Germany
Hum Genet 119:305-11. 2006.... - Evaluation of the pediatric crohn disease activity index: a prospective multicenter experienceJeffrey Hyams
Connecticut Children s Medical Center, Hartford, Connecticut, USA
J Pediatr Gastroenterol Nutr 41:416-21. 2005.... - A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's diseaseAthos Bousvaros
Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
Inflamm Bowel Dis 11:833-9. 2005..18). The LGG was well tolerated, with a side effect profile comparable with placebo. This study suggests that LGG does not prolong time to relapse in children with CD when given as an adjunct to standard therapy... - Challenges in pediatric inflammatory bowel diseaseAthos Bousvaros
Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Inflamm Bowel Dis 12:885-913. 2006..At the conclusion of the meeting, investigators discussed the formation of a multicenter collaborative network to advance clinical and basic research in the field... - Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's diseaseDan Turner
Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Am J Gastroenterol 102:2804-12; quiz 2803, 2813. 2007..We report outcomes with methotrexate treatment in pediatric patients previously refractory to or intolerant of thiopurines... - Guidelines for immunizations in patients with inflammatory bowel diseaseBruce E Sands
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Inflamm Bowel Dis 10:677-92. 2004..We conclude that for most patients with IBD, recommendations for immunization do not deviate from recommended schedules for the general population...
Research Grants
- MUCOSAL T-CELLS IN EARLY&LATE PEDIATRIC CROHN'S DISEASESubra Kugathasan; Fiscal Year: 2005..abstract_text> ..