M A Judson

..Several factors associated with improved or worse outcome over two years were identified...

..In particular, the study sought to determine whether the CXR changes were a reliable indicator of disease exacerbation...

..Infliximab may be beneficial compared with placebo in the treatment of extrapulmonary sarcoidosis in patients already receiving corticosteroids, as assessed by the severity tool described in the present study...

..The end result of this diagnostic evaluation for sarcoidosis is neither a definitive diagnosis nor an exclusion of the diagnosis, but rather a statistical likelihood of the disease...

..Although this instrument is presently not validated, it is hoped that it will undergo study as it rationally accounts for several problems of previous assessment instruments...

..We suspect that infliximab disrupted the T-helper (Th) type 1-Th2 lymphocyte balance such that Th2 cytokines were left relatively unopposed, promoting the development of ABPA...

..To examine the time from the first physician visit to the diagnosis of sarcoidosis...

..This article outlines the approach to the evaluation and treatment of sarcoidosis by primary care physicians...

..This article reviews the clinical presentation and therapy of extrapulmonary sarcoidosis...

..Atypical presentations may result in a delay in diagnosis as well as unnecessary treatment or diagnostic testing. We discuss four patients with an unusual presentation of thoracic sarcoidosis seen at our Sarcoidosis Clinic...

..Additional clues are the presence of mediastinal adenopathy on a chest radiograph or a CT scan and a history consistent with extrapulmonary sarcoidosis...

..This article describes the use of corticosteroids for pulmonary sarcoidosis in terms of the above six phases. The proposed dosing schedules are based on the natural history of the disease and the results from published treatment studies...

..Sarcoidosis may remit spontaneously or remain stable. Therefore, therapy is not mandated for the disease. This report reviews the clinical presentation, diagnostic approach, and treatment of sarcoidosis...

..CT-guided direct intralesional transthoracic injection of dexamethasone resulted in resolution of the patient's symptoms and a dramatic reduction in the size of the mass within 2 months...

..To test the hypothesis that sibling pairs, who share genes and environmental exposures, might have similar phenotypic expressions of sarcoidosis beyond what would be expected by chance alone...

..Multiple asthmatic exacerbations in a patient with ABPA suggest that chronic steroid therapy should be used. Itraconazole appears useful as a steroid sparing agent...

..Few patients can tolerate doses of greater than 100 mg/day. Thalidomide may have been corticosteroid-sparing in a subgroup of these patients...

..This article will review the epidemiology, diagnostic evaluation, and description of the various chronic skin lesions of sarcoidosis. Various images of these skin lesions will be demonstrated...

..It has also been reported to be elevated in certain granulomatous conditions. We describe a patient with sarcoidosis and an elevated serum CA 125 level and review the medical literature on this topic...

..Infliximab appears to be steroid sparing. Patients receiving the drug should be screened for latent tuberculosis and lymphoproliferative disorders...

..We performed thoracic ultrasonography prospectively in consecutive outpatients with sarcoidosis to determine the frequency of PEs caused by sarcoidosis and to define their pleural fluid characteristics...

..Tumor necrosis factor-alpha (TNF-alpha) antagonists such as infliximab may have a role in cutaneous sarcoidosis, especially in refractory cases that are resistant to the standard regimens...

..Sarcoidosis associated pulmonary hypertension (SAPH) is associated with significant morbidity and mortality. There is a paucity of information concerning therapy for this condition...

..The present study is a descriptive, retrospective one using endoscopic ultrasound with fine-needle aspiration (EUS-FNA) of mediastinal lymph nodes in seven patients with sarcoidosis...

..CONCLUSION: Short-course cyclophosphamide appears to be a reasonable, steroid-sparing treatment option for patients with corticosteroid-refractory neurosarcoidosis...

..Infliximab appears to be efficacious for the treatment of recalcitrant forms of sarcoidosis. However, there are minimal data concerning the course of sarcoidosis once infliximab is discontinued...

..Atypical mycobacteria have not been reported as the etiology of pulmonary nodules in a heart transplant recipient. We report a case of Mycobacterium scrofulaceum infection presenting as three discrete pulmonary nodules...

..To the best of our knowledge, this is the shortest period of time over which the treatment of pulmonary sarcoidosis with corticosteroids has been assessed...

..The presenting symptoms, clinical outcome, radiographs and laryngeal findings are discussed in detail. Sarcoidosis should therefore be added to the differential diagnosis of bilateral vocal fold paralysis...

..To our knowledge, this is the first reported case of this entity. An additional unusual finding was that her symptoms of gynecologic sarcoidosis occurred at the time of initial presentation of her pulmonary sarcoidosis...

..Although metalloptysis usually requires no therapy, it may indicate an active infectious process that requires appropriate therapy...

..Our findings suggest that CTS is common in sarcoidosis...

..The objective was to survey sarcoidosis experts concerning the treatment of pulmonary sarcoidosis and attempt to reach a consensus by these experts using a Delphi method...

..Histologic examination of the lung, visceral and parietal pleura, and the fibrous adhesions all revealed noncaseating granulomas...

..The reported sensitivity and specificity must be appreciated in the context of the difficult and often incomplete clinical diagnosis of sarcoidosis...

..To report a case of valproic acid-induced eosinophilic pleural effusion and to review the existing literature...

..The purpose of this study was to assess the utility of EBUS-TBNA for pulmonary sarcoidosis...

..To describe the health-related quality of life (HRQL) and mental health of persons with sarcoidosis, as well as to assess physician-patient agreement about the presence of sarcoidosis symptoms...

..Clinicians must decide which site offers the best chance of achieving a diagnostic biopsy with the least patient risk and discomfort...

..Evidence suggests that tumor necrosis factor (TNF)-alpha plays an important role in the pathophysiology of sarcoidosis...

..Lupus pernio is a skin manifestation of sarcoidosis that does not remit spontaneously, and was used as a marker of efficacy of thalidomide for sarcoidosis...

..Facial lesions including lupus pernio are often a form of chronic cutaneous sarcoidosis...

..The SHQ alone was sensitive to differences in HRQL based on the number of involved organ systems. In conclusion, we have developed a self-completed HRQL questionnaire for U.S. patients with sarcoidosis...

..Inhaled corticosteroids have been used with variable success in sarcoidosis. The role of the inhaled corticosteroid fluticasone in symptomatic pulmonary patients was studied...

..65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols...

..The influences of genetics and socioeconomic status on the development and phenotypic expression of sarcoidosis will be better understood as the mechanisms of disease development are uncovered...

..To assess lung involvement and the association of demographic and psychosocial factors with respiratory health in 736 persons with sarcoidosis at enrollment in A Case Control Etiologic Study of Sarcoidosis (ACCESS)...

..We examined the relationship between environmental and occupational exposures, and the clinical phenotype of sarcoidosis...

..In the United States of America, African Americans have a higher sarcoidosis incidence and suffer greater morbidity than Caucasians...

..This preliminary tool has potential applicability in the assessment of disease severity in sarcoidosis research...

..To describe the current state of knowledge concerning health-related quality of life research in sarcoidosis and suggest new approaches that could be explored...

..To determine whether specific occupations and industries may be associated with sarcoidosis...

..Improving access to care and addressing other disparities in health care may help to bridge the gap in health outcomes observed between patients...

..Relapses occur frequently, usually when treatment is withdrawn or tapered. The prognosis is good in most of the cases of COP, whereas in SOP it is dependent on the underlying cause...