Research Topics
Genomes and Genes | John D ImigSummaryAffiliation: Medical College of Georgia Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ ChannelsJohn D Imig
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Microcirculation 15:137-50. 2008..These data support the concept that 11, 12-EET utilizes PP2A dependent pathways to activate large-conductance KCa channels and dilate the afferent arteriole...- Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitorsJohn D Imig
Department of Physiology, Vascular Biology Center, Medical College of Georgia, Augusta, 30912, USA
Cardiovasc Drug Rev 24:169-88. 2006..These findings of beneficial actions in animal models of disease position the sEH enzyme as a promising therapeutic target for cardiovascular diseases... - Eicosanoids and renal damage in cardiometabolic syndromeJohn D Imig
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Expert Opin Drug Metab Toxicol 4:165-74. 2008..Although the number of patients with cardiometabolic syndrome is escalating, therapeutic approaches have not been developed that provide protection to the kidney... - Eicosanoids and renal vascular function in diseasesJohn D Imig
Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
Clin Sci (Lond) 111:21-34. 2006..This review highlights the roles of renal vascular eicosanoids in the pathogenesis of nephropathy and therapeutic targets for renal disease related to hypertension, diabetes, metabolic syndrome and acute renal failure... - Rofecoxib decreases renal injury in obese Zucker ratsAparajita Dey
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Clin Sci (Lond) 107:561-70. 2004..These results suggest that altered vascular arachidonic acid enzymes contribute to the renal damage, and that COX-2 inhibition decreases glomerular injury in obese Zucker rats... - PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker ratsXueying Zhao
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500
Am J Physiol Heart Circ Physiol 290:H2187-95. 2006..These results demonstrate that the PPAR-alpha agonist fenofibrate increased renal CYP-derived eicosanoids and restored endothelial dilator function in obese Zucker rats... - Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertensionMarlina Manhiani
Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
Am J Physiol Renal Physiol 297:F740-8. 2009..These data demonstrate that Ephx2 gene deletion decreases blood pressure, attenuates renal inflammation, and ameliorates glomerular injury in DOCA-salt hypertension... - Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive ratsAhmed A Elmarakby
Department of Oral Biology Pharmacology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, U S A
Clin Sci (Lond) 118:291-301. 2010..These results suggest that ANG-induced hypertension exacerbates oxidative stress and renal inflammation without further impairment in vascular dysfunction in high-fat diet-induced obesity... - Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki ratsJeffrey J Olearczyk
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Clin Sci (Lond) 116:61-70. 2009..Taken together, these results provide evidence that sEH inhibition with AUDA attenuates the progression of renal damage associated with hypertension and Type 2 diabetes... - Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertensionXueying Zhao
Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-3000, USA
Hypertension 46:562-8. 2005..These results indicate that the impaired autoregulatory response observed in Ang II-dependent hypertension can be attributed to impairment of P2X1 receptor-mediated signal transduction... - TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive ratsAhmed A Elmarakby
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
Am J Physiol Regul Integr Comp Physiol 294:R76-83. 2008..These data support the hypothesis that TNF-alpha contributes to the increase in renal inflammation in DOCA-salt rats... - Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetesAhmed A Elmarakby
Georgia Health Sciences Univ, Augusta, GA, 30912
Am J Physiol Regul Integr Comp Physiol 301:R1307-17. 2011..These data demonstrate that Ephx2 KO improves endothelial function and reduces renal injury during diabetes. Additionally, our data also suggest that activation of HO-1 contributes to improved renal injury in diabetic Ephx2 KO mice... - Novel nitric oxide synthase--dependent mechanism of vasorelaxation in small arteries from hypertensive ratsKyu Tae Kang
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
Hypertension 49:893-901. 2007.... - Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertensionSarah F Knight
Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
Am J Physiol Renal Physiol 298:F86-94. 2010..These data indicate that tempol and simvastatin treatment via a reduction in oxidative stress improve renal endothelial function and decrease glomerular injury in a model of obesity and hypertension... - Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker ratsXueying Zhao
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
Am J Physiol Regul Integr Comp Physiol 288:R188-96. 2005.... - Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat dietSarah F Knight
Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
Hypertension 51:352-9. 2008.... - An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertensionJohn D Imig
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
Hypertension 46:975-81. 2005..These data demonstrate that sEH inhibition lowers blood pressure and ameliorates renal damage in angiotensin-dependent, salt-sensitive hypertension... - Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuriaAparajita Dey
Vascular Biology Center, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912, USA
Obes Res 12:1278-89. 2004..To determine cytochrome P450 (CYP450) and cyclooxygenase (COX) expression and metabolite regulation and renal damage in the early stages of obesity-related hypertension and diabetes... - Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertensionAhmed A Elmarakby
Vascular Biology Center, Medical College of Georgia, Augusta 30912 2500, USA
Hypertension 50:1069-76. 2007..These data suggest that CCR2b inhibition protects the kidney in hypertension by reducing inflammation and delaying the progression of hypertension... - Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damageXueying Zhao
Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, USA
J Am Soc Nephrol 15:1244-53. 2004..These data demonstrate that SEH inhibition has antihypertensive and renal vascular protective effects in angiotensin hypertension and suggests that SEH inhibitors may be a useful therapeutic intervention for cardiovascular diseases... - Obesity induced renal oxidative stress contributes to renal injury in salt-sensitive hypertensionJeffrey E Quigley
Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
Clin Exp Pharmacol Physiol 36:724-8. 2009.... - Normalization of the ovarian cancer microenvironment by SPARCNeveen Said
Vascular Biology Center, Medical College of Georgia, Augusta, Georgea 30912, USA
Mol Cancer Res 5:1015-30. 2007.... - Salt-sensitive hypertension after exposure to angiotensin is associated with inability to upregulate renal epoxygenasesXueying Zhao
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
Hypertension 42:775-80. 2003..These results support the hypothesis that angiotensin II infusion induces persistent salt-sensitive hypertension after withdrawal of angiotensin II that may be due to downregulation of CYP2C and CYP2J epoxygenases in renal microvessels... - An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive ratsAnne M Dorrance
Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
J Cardiovasc Pharmacol 46:842-8. 2005..The results of this study provide novel evidence suggesting that the sEH inhibitor AUDA is a possible therapeutic agent for ischemic stroke... - Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxationChristiana Dimitropoulou
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, USA
Prostaglandins Other Lipid Mediat 83:50-61. 2007..These findings provide initial evidence that PP2A activity contributes to 11,12-EET and 11,12-EET analog activation of mesenteric resistant artery BK(Ca) channels and vasorelaxation... - Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertensionAhmed A Elmarakby
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA
Vascul Pharmacol 46:144-51. 2007..These data support the hypothesis that combined reduction of superoxide along with enhanced endogenous kinins may facilitate blood pressure lowering in Ang II hypertension... - Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vesselsJeffrey J Olearczyk
The Medical College of Georgia, Vascular Biology Center, Augusta, GA 30912, USA
J Pharmacol Exp Ther 318:1307-14. 2006.... - Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptorJia L Zhuo
Department of Physiology, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, Louisiana 70112, USA
Hypertension 39:116-21. 2002..These results indicate that there is substantial intracellular accumulation of angiotensin peptides in renal cortical endosomes during Ang II-dependent hypertension via an AT(1) receptor-mediated process... - Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertensionMong Heng Wang
Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
Hypertension 42:594-9. 2003..The reduction in the synthesis of these eicosanoids may play an important role in the regulation of renal function and blood pressure in obesity-induced hypertension... - SPARC ameliorates ovarian cancer-associated inflammationNeveen A Said
Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
Neoplasia 10:1092-104. 2008..These results indicate, for the first time, that the effects of tumor SPARC as a negative regulator of ovarian cancer are mediated through decreased recruitment of macrophages and downregulation of the associated inflammation... - Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertensionAhmed A Elmarakby
Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
Hypertension 47:557-62. 2006..These data suggest that TNF-alpha contributes to downregulation of Cyp2c23, blood pressure regulation, and renal injury in angiotensin high-salt hypertension... - Cytochrome P450 epoxygenases provide a novel mechanism for penile erectionLiming Jin
Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
FASEB J 20:539-41. 2006..Inhibition of this pathway attenuated erectile function, suggesting that EETs are required for normal erection... - P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acidXueying Zhao
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
J Pharmacol Exp Ther 311:1211-7. 2004..These results demonstrate that 20-HETE plays a significant role in the renal microvascular smooth muscle cell [Ca2+]i response to P2X receptor activation... - L-type calcium channels in the renal microcirculatory response to endothelinDavid M Pollock
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
Am J Physiol Renal Physiol 288:F771-7. 2005..These results support the hypothesis that L-type Ca(2+) channels play only a minor role in the constrictor responses to ET-1 in the renal microcirculation... - ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelinEdward W Inscho
Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
Br J Pharmacol 146:1019-26. 2005.... - Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activationEdward W Inscho
Department of Physiology and Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
J Hypertens 22:811-8. 2004..These studies determined the ability of AT1 receptor blockade or 'triple therapy', to reverse angiotensin II-induced hypertension and improve autoregulatory behavior... - Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockadeJan Michael Williams
Department of Physiology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
Hypertension 46:366-71. 2005..This suggests a possible relationship between ETB receptor activation and the maintenance of CYP4A protein expression in the kidney of rats fed a high-salt diet... - Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive ratsLiming Jin
Department of Physiology, Medical College of Georgia, Augusta, GA, USA
J Pharmacol Exp Ther 318:288-95. 2006..Increased NADPH oxidase-dependent reactive oxygen species may be one of the mechanisms mediating the RhoA/Rho-kinase activation... - Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertensionXueying Zhao
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
Hypertension 41:709-14. 2003.... - Angiotensin II hypertension is attenuated in interleukin-6 knockout miceDexter L Lee
Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
Am J Physiol Heart Circ Physiol 290:H935-40. 2006..In addition, the early separation in MAP, the albumin excretion data, and the rapid, post-ANG II recovery of MAP suggest an IL-6-dependent mechanism that is independent of renal injury... - 12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channelsShih Shen Yiu
Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
J Lipid Res 44:2391-9. 2003.... - Physiological role for P2X1 receptors in renal microvascular autoregulatory behaviorEdward W Inscho
Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912 3000, USA
J Clin Invest 112:1895-905. 2003..These data provide compelling new evidence indicating that tubuloglomerular feedback signals are coupled to autoregulatory preglomerular vasoconstriction through ATP-mediated activation of P2X1 receptors... - Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertensionMatthew J Socha
Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB 3306, Augusta, GA 30912, USA
Am J Pathol 171:1104-12. 2007..These results identify SPARC as an effector of ANG II signaling and suggest an important role for SPARC in mediating ANG II-induced oxidative stress, inflammation, and fibrosis... - Renal AT1 receptor protein expression during the early stage of diabetes mellitusLisa M Harrison-Bernard
Department of Physiology, Tulane University School of Medicine, New Orleans, LA, USA
Int J Exp Diabetes Res 3:97-108. 2002..Increased renal cortical AT1 receptor protein and circulating AngII levels are consistent with an exaggerated AngII-dependent influence on renal function during the early stage of DM in the rat... - Contribution of prostaglandin EP(2) receptors to renal microvascular reactivity in miceJohn D Imig
Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
Am J Physiol Renal Physiol 283:F415-22. 2002..These results demonstrate that the EP(2) receptor mediates a portion of the PGE(2) afferent arteriolar vasodilation and buffers the renal vasoconstrictor responses elicited by EP(1) and EP(3) receptor activation as well as endothelin-1... - The Bradykinin B2 receptor is required for full expression of renal COX-2 and reninJohn D Imig
Department of Physiology, Medical College of Georgia, Vascular Biology Center, Augusta, GA 30912 2500, USA
Peptides 24:1141-7. 2003..The results of these studies demonstrate suppression of renal renin synthesis in mice lacking the bradykinin B2R and support the notion that B2R regulation of COX-2 participates in the steady-state control of renin gene expression... - Obesity, insulin resistance, and renal functionSarah F Knight
Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
Microcirculation 14:349-62. 2007.... - Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseasesJohn D Imig
Vascular Biology Ctr, Medical College of Georgia, Augusta, GA 30912 2500, USA
Am J Physiol Renal Physiol 289:F496-503. 2005..Thus the renal and cardiovascular protective actions of increasing epoxygenase levels could be translated to therapies for preventing end-organ damage... - Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertensionJohn D Imig
Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
Hypertension 39:690-4. 2002..Moreover, sEH plays a role in the regulation of blood pressure, and inhibition of sEH during Ang II hypertension is antihypertensive... - Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathyXueying Zhao
Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
Am J Nephrol 34:268-80. 2011..Studies have shown that kidney injury molecule-1 (KIM-1) is upregulated in damaged renal proximal tubules. In this study, we examined KIM-1 expression in glomerular epithelial cells in diabetic glomerulopathy... - Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female ratsJennifer C Sullivan
Medical College of Georgia, Vascular Biology Center, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
J Appl Physiol 97:1268-74. 2004..These data suggest that age-related alterations in the resistance vasculature are complex and likely involve multiple compensating vasoactive pathways... - Adaptations of the renal microcirculation to hypertensionJohn D Imig
Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
Microcirculation 9:315-28. 2002.... - ACE Inhibition and Bradykinin-Mediated Renal Vascular Responses: EDHF InvolvementJohn D Imig
Hypertension 43:533-5. 2004 - Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetesVera Portik-Dobos
Program in Clinical and Experimental Therapeutics, Univerisity of Georgia, College of Pharmacy, Georgia 3091, USA
Am J Physiol Regul Integr Comp Physiol 290:R435-41. 2006..Although the ET(A) receptor subtype is not involved in the early activation of MMPs in type 2 diabetes, ET-1 contributes to transactivation of growth-promoting and profibrotic EGFR... - 20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis?John D Imig
Am J Physiol Regul Integr Comp Physiol 287:R3-5. 2004 - The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic ratsVera Certíková Chábová
Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Kidney Blood Press Res 30:335-46. 2007..Second, the renal functional responses to inhibition of the intrarenal formation of 20-HETE and EETs were investigated... - Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targetingYoufei Guan
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Clin Invest 117:2496-505. 2007..Similarly, the pressor response to EP1-selective agonists sulprostone and 17-phenyltrinor PGE2 were blunted by SC51322 and in EP1-null mice. These data support the possibility of targeting the EP1 receptor for antihypertensive therapy... - Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic ratsVěra Čertíková Chábová
Department of Nephrology, 1st Medical Faculty, Charles University, Prague, Czech Republic
Vascul Pharmacol 47:145-59. 2007..Our data suggest that altered production and/or action of CYP-derived metabolites play a permissive role in the development and maintenance of hypertension in TGR by enhancing ANG II-induced vasoconstriction... - Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cellsAndrew J Fuller
Dept. of Physiology SL#39, Tulane Univ. School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, USA
Am J Physiol Renal Physiol 289:F760-7. 2005..The finding that chloride channel blockers markedly attenuate both rapid and sustained responses indicates that chloride channel activation contributes to, rather than being the consequence of, the initial rapid response... - Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptorsJian Kang Chen
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 283:24514-24. 2008....
Research Grants
- Novel epoxide hydrolase inhibitor for stroke preventionJOHN IMIG; Fiscal Year: 2005..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..